DHRS9: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

DHRS9

Aliases

3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDH-TBE, RDH15, RDHL, RDHTBE, RETSDR8, SDR9C4

Entrez Gene ID

10170

Gene Name

Dehydrogenase/reductase 9

Chromosomal Location

2q31.1

HGNC ID

HGNC:16888

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

e!Ensembl

Gene	ENSG00000073737
Transcript	ENST00000602501, ENST00000357546, ENST00000428522, ENST00000450153, ENST00000421653, ENST00000436483, ENST00000412271, ENST00000432060
Protein	ENSP00000473337, ENSP00000350154, ENSP00000388564, ENSP00000391214, ENSP00000388066, ENSP00000407167, ENSP00000407747, ENSP00000389241

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0008209	Biological process	Androgen metabolic process	IDA	11294878
GO:0030855	Biological process	Epithelial cell differentiation	NAS	11304534
GO:0042448	Biological process	Progesterone metabolic process	IDA	11294878
GO:0042572	Biological process	Retinol metabolic process	NAS	11304534
GO:0042904	Biological process	9-cis-retinoic acid biosynthetic process	IDA	11304534
GO:0030176	Cellular component	Integral component of endoplasmic reticulum membrane	IDA	11294878
GO:0004022	Molecular function	Alcohol dehydrogenase (NAD) activity	IDA	11304534
GO:0004745	Molecular function	Retinol dehydrogenase activity	IDA	11304534
GO:0016854	Molecular function	Racemase and epimerase activity	NAS	11294878
GO:0047023	Molecular function	Androsterone dehydrogenase activity	IDA	11294878
GO:0047035	Molecular function	Testosterone dehydrogenase (NAD+) activity	IDA	11294878
GO:0047044	Molecular function	Androstan-3-alpha,17-beta-diol dehydrogenase activity	IDA	11294878

Protein Information

Protein Name

Dehydrogenase/reductase SDR family member 9, 3-alpha hydroxysteroid dehydrogenase, NADP-dependent retinol dehydrogenase/reductase, dehydrogenase/reductase (SDR family) member 9, retinol dehydrogenase 15, retinol dehydrogenase homolog, short chain dehydrogenase/reductase family 9C member 4, short-chain dehydrogenase/reductase retSDR8, tracheobronchial epithelial cell-specific retinol dehydrogenase

Function

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Plays also a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH

UniProt

Q9BPW9

Pfam

Pfam Accession	Pfam ID
PF00106	adh_short