ESR2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ESR2

Aliases

ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8

Entrez Gene ID

2100

Gene Name

Estrogen receptor 2

Chromosomal Location

14q23.2-q23.3

HGNC ID

HGNC:3468

Summary

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_011535.1

RefSeq mRNA

NM_001040275.1, NR_073496.2, NR_073497.1, NM_001437.2, NM_001214902.1, NM_001271876.1, NM_001271877.1, NM_001291712.2, NM_001291723.1

e!Ensembl

Gene	ENSG00000140009
Transcript	ENST00000556275, ENST00000554572, ENST00000358599, ENST00000555278, ENST00000344288, ENST00000553796, ENST00000557772, ENST00000341099, ENST00000267525, ENST00000353772
Protein	ENSP00000452485, ENSP00000450699, ENSP00000351412, ENSP00000450488, ENSP00000345616, ENSP00000452426, ENSP00000451582, ENSP00000343925, ENSP00000267525, ENSP00000335551

Gene Ontology (GO)

Show/Hide all(29 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IDA	15345745
GO:0006355	Biological process	Regulation of transcription, DNA-templated	TAS	11181953
GO:0007165	Biological process	Signal transduction	TAS	8769313, 10749889
GO:0007267	Biological process	Cell-cell signaling	TAS	8769313
GO:0030308	Biological process	Negative regulation of cell growth	NAS	11181953
GO:0030520	Biological process	Intracellular estrogen receptor signaling pathway	TAS	11181953
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	20074560
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IDA	10681512
GO:0005634	Cellular component	Nucleus	IDA	19126643, 20074560
GO:0005634	Cellular component	Nucleus	TAS	11181953
GO:0005739	Cellular component	Mitochondrion	IDA	15024130
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA	15345745
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0003677	Molecular function	DNA binding	TAS	9636657
GO:0003700	Molecular function	DNA-binding transcription factor activity	TAS	8769313
GO:0003707	Molecular function	Steroid hormone receptor activity	TAS	10749889
GO:0003713	Molecular function	Transcription coactivator activity	TAS	8769313
GO:0004879	Molecular function	Nuclear receptor activity	IDA	19126643
GO:0004879	Molecular function	Nuclear receptor activity	NAS	9671811
GO:0005496	Molecular function	Steroid binding	TAS	11181953
GO:0005515	Molecular function	Protein binding	IPI	11279242, 12904255, 14764652, 15199063, 19022902, 19126643, 20074560, 21629692, 21951318, 25416956
GO:0019899	Molecular function	Enzyme binding	IPI	12039952
GO:0030284	Molecular function	Estrogen receptor activity	IDA	19126643
GO:0030284	Molecular function	Estrogen receptor activity	IMP	29261182, 30113650
GO:0030284	Molecular function	Estrogen receptor activity	TAS	11181953
GO:0034056	Molecular function	Estrogen response element binding	IDA	15345745, 19126643
GO:0042802	Molecular function	Identical protein binding	IPI	19022902, 21182203, 21951318
GO:0048019	Molecular function	Receptor antagonist activity	NAS	9671811

Protein Information

Protein Name

Estrogen receptor beta, estrogen receptor beta 4, estrogen receptor beta splice variant, ERbeta2delta7, estrogen receptor beta splice variant, ERbeta4delta7, estrogen receptor beta splice variant, ERbeta6, estrogen receptor beta splice variant, ERbeta6delta7, estrogen receptor beta splice variant, ERbeta7, estrogen receptor beta splice variant, ERbeta7delta7, estrogen receptor beta splice variant, ERbetaEx. 4L, estrogen receptor beta splice variant, ERbetaEx. 6L, nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta

Function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Refseq Proteins

NP_001035365.1, , NP_001428.1, NP_001201831.1, NP_001258805.1, NP_001258806.1, NP_001278641.1, NP_001278652.1

UniProt

Q92731

PDB

1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4J26, 4ZI1, 5TOA