F3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

Aliases

CD142, TF, TFA

Entrez Gene ID

2152

Gene Name

Coagulation factor III, tissue factor

Chromosomal Location

1p21.3

HGNC ID

HGNC:3541

Summary

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

RefSeq DNA

NG_029366.1

RefSeq mRNA

NM_001993.5, NM_001178096.1

e!Ensembl

Gene	ENSG00000117525
Transcript	ENST00000334047, ENST00000370207
Protein	ENSP00000334145, ENSP00000359226

Gene Ontology (GO)

Show/Hide all(24 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IDA	17898544
GO:0002541	Biological process	Activation of plasma proteins involved in acute inflammatory response	IDA	17469850
GO:0002543	Biological process	Activation of blood coagulation via clotting cascade	IC	17469850
GO:0006919	Biological process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	17898544
GO:0007596	Biological process	Blood coagulation	IDA	8632006, 24998411
GO:0010641	Biological process	Positive regulation of platelet-derived growth factor receptor signaling pathway	IDA	17991872
GO:0016485	Biological process	Protein processing	IDA	24998411
GO:0019221	Biological process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0030335	Biological process	Positive regulation of cell migration	TAS	18612547
GO:0045766	Biological process	Positive regulation of angiogenesis	IDA	17898544
GO:0050927	Biological process	Positive regulation of positive chemotaxis	IC	17991872
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IMP	18612547
GO:0005615	Cellular component	Extracellular space	IDA	19065458
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0009986	Cellular component	Cell surface	HDA	19581412
GO:0009986	Cellular component	Cell surface	IDA	17898544
GO:0031233	Cellular component	Intrinsic component of external side of plasma membrane	IC	17469850
GO:0062023	Cellular component	Collagen-containing extracellular matrix	IDA	2704749
GO:1905286	Cellular component	Serine-type peptidase complex	IPI	24998411
GO:0002020	Molecular function	Protease binding	IPI	3455766
GO:0004252	Molecular function	Serine-type endopeptidase activity	IDA	24998411
GO:0004896	Molecular function	Cytokine receptor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	8598903, 8940045, 9414278, 15522303, 15664864, 16959886, 20634491, 25241761
GO:0005543	Molecular function	Phospholipid binding	IDA	17469850

Protein Information

Protein Name

Tissue factor, coagulation factor III (thromboplastin, tissue factor)

Function

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Refseq Proteins

NP_001984.1, NP_001171567.1

UniProt

P13726

PDB

1NL8, 1DAN, 1FAK, 1J9C, 1O5D, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4YLQ, 4Z6A, 4ZMA, 1AHW, 1BOY, 1JPS, 1TFH, 1UJ3, 2CEF, 2CEH, 2CEZ, 2CFJ, 2HFT, 4M7L, 5W06

Pfam

Pfam Accession	Pfam ID
PF09294	Interfer-bind
PF01108	Tissue_fac