Gene Symbol

F5

Aliases

FVL, PCCF, RPRGL1, THPH2

Entrez Gene ID

2153

Gene Name

Coagulation factor V

Chromosomal Location

1q24.2

HGNC ID

HGNC:3542

Summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

Function

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin

P12259

PDB

1CZS, 1CZT, 1CZV, 1FV4, 1Y61, 3P6Z, 3P70, 3S9C

STRING	MINT	IntAct
ENSP00000478570	P15692	P15692