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Gene Symbol |
FAAH |
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Aliases |
FAAH-1, PSAB |
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Entrez Gene ID |
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Gene Name |
Fatty acid amide hydrolase |
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Chromosomal Location |
1p33 |
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HGNC ID |
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Summary |
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Fatty-acid amide hydrolase 1, anandamide amidohydrolase 1, oleamide hydrolase 1 |
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Function |
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Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. |
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UniProt |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF01425 |
Amidase |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000413496 |
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P61328 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Atonic seizures |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Breast Cancer |
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| Nervous System Diseases |
| Seizures |
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| Jacksonian Seizure |
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| Huntington Disease |
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| Nutritional and Metabolic Diseases |
| Obesity |
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| Psychiatric/Brain disorders |
| Mental Depression |
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| Psychosis |
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| Mood Disorders |
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| Schizophrenia |
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| Non-organic psychosis |
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References |
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| Cui Na, Yang Yang, Xu Yueming, Zhang Jie, Jiang Lei, Hao Guimin |
| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.| a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China. |
| Gynecol Endocrinol. 2017 May;33(5):368-372. doi: 10.1080/09513590.2016.1269742. |
Abstract
This study aimed to investigate the correlation between endocannabinoids and polycystic ovary syndrome (PCOS), and the expression levels of endocannabinoids in different phases of menstruation. The expression of cannabinoid receptors (CB1) and fatty acid amide hydrolase (FAAH) in the endometrium were immunohistochemically stained and compared between women with PCOS and the control group. Integrated optical density (IOD) was assessed to analyze their expression levels. The CB1 and FAAH were expressed in endometrial epithelial cytoplasm. No significant difference in CB1 level was observed between PCOS and non-PCOS women. Additionally, the expression of CB1 did not fluctuate with menstrual cycle. However, the FAAH levels were lower in the PCOS group than the non-PCOS group (p < 0.05). FAAH levels in secretory phases were significantly elevated compared to menstrual and proliferative phases (p < 0.05). Our results demonstrate that the endocannabinoid system may play an important role in menstruation, and dysregulation of the system may result in PCOS. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
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