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Gene Symbol |
FASN |
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Aliases |
FAS, OA-519, SDR27X1 |
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Entrez Gene ID |
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Gene Name |
Fatty acid synthase |
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Chromosomal Location |
17q25.3 |
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HGNC ID |
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Summary |
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
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e!Ensembl
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| Protein Information |
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Protein Name |
Fatty acid synthase, short chain dehydrogenase/reductase family 27X, member 1 |
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Function |
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Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein |
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UniProt |
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PDB |
2CG5, 1XKT, 2JFD, 2JFK, 2PX6, 3HHD, 3TJM, 4PIV, 4W82, 4W9N, 4Z49, 5C37, 6NNA |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000304592 |
P49327 |
P49327 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Myocardial Failure |
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| Hypertensive disease |
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| Atherosclerosis |
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| Acute Coronary Syndrome |
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| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| PINK1 deficiency |
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| Sickle Cell Anemia |
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| Digestive System Diseases |
| Liver Diseases |
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| Fatty Liver |
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| Alcoholic fatty liver |
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| Hepatitis |
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| Non-alcoholic Fatty Liver Disease |
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| Endocrine System Diseases |
| PCOS |
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| Thyroid Diseases |
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| Diabetes Mellitus |
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| Eye Diseases |
| Retinoblastoma |
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| Immune System Diseases |
| HIV Infections |
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| Musculoskeletal Diseases |
| Myopathy |
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| Neoplasms |
| Prostate cancer |
30578319, 29668854, 29784665, 27357679, 27331874, 25868764, 26934656, 28342983, 28418352, 30667363, 21170507, 23741342, 22064655, 22670709 |
| Gastric Cancer |
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| Liver Cancer |
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| Breast Cancer |
29751678, 27106068, 27270654, 29282029, 25751270, 26774147, 25924435, 27579768, 26107737, 27714708, 22177475, 22767439, 27064010, 20531416, 25442282, 24866893, 23982110, 25448084, 23417336, 23370361, 21806057, 20218616 |
| Lung Cancer |
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| Uterine Fibroids |
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| Colorectal Cancer |
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| Pancreatic Neoplasm |
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| Skin Cancer |
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| Carcinoma |
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| Glioma |
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| Bladder Cancer |
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| Glioblastoma |
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| Neoplasms |
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| Osteosarcoma |
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| Colonic Neoplasms |
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| Leukemia |
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| Ovarian Cancer |
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| Endometrial Cancer |
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| Thyroid Cancer |
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| Squamous Cell Carcinoma |
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| Intraepithelial Neoplasia |
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| Lymphoma |
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| Prostate Carcinoma |
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| Nose Cancer |
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| Sarcoma |
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| Nutritional and Metabolic Diseases |
| Hyperglycemia |
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| Metabolic Diseases |
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| Dyslipidemias |
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| Obesity |
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| Lipid Metabolism Disorders |
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| Metabolic Syndrome X |
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| Psychiatric/Brain disorders |
| Mental Depression |
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| Renal Disorder |
| Kidney Failure |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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PCOS, Lipid metabolism, Steroidogenesis and follicular growth |
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Direct
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39 PCOS subjects and 30 PCOS controls |
The present study discloses decrease in insulin signaling proteins related to metabolism, lipogenic genes and steroidogenesis in PCOS-IR group as against decrease only in steroidogenesis in PCOS-NIR group. These differential signaling molecules ultimately might be involved in the prevalence of hyperinsulinemia and hyperandrogenemia in PCOS-IR group and intrinsic ovarian defects in PCOSNIR group leading to follicular arrest, poor oocyte growth as well as quality observed in different PCOS phenotypes. The study would aid in designing candidate molecules for targeted therapy towards the two different types of PCOS thus decreasing probability of reproductive failures. |
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