FLOT1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

FLOT1

Aliases

Entrez Gene ID

10211

Gene Name

Flotillin 1

Chromosomal Location

6p21.33

HGNC ID

HGNC:3757

Summary

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

e!Ensembl

Gene	ENSG00000206379, ENSG00000232280, ENSG00000223654, ENSG00000230143, ENSG00000137312, ENSG00000224740, ENSG00000206480, ENSG00000236271
Transcript	ENST00000383382, ENST00000422636, ENST00000454249, ENST00000438134, ENST00000421565, ENST00000416389, ENST00000439743, ENST00000436822, ENST00000445669, ENST00000431913, ENST00000411778, ENST00000436197, ENST00000445319, ENST00000456844, ENST00000420604, ENST00000444632, ENST00000424683, ENST00000439376, ENST00000427784, ENST00000444497, ENST00000445383, ENST00000458306, ENST00000376389, ENST00000413165, ENST00000438162, ENST00000418160, ENST00000445853, ENST00000416018, ENST00000454845, ENST00000446072, ENST00000457133, ENST00000432428, ENST00000439396, ENST00000437093, ENST00000422714, ENST00000436025, ENST00000383562, ENST00000456042, ENST00000442932, ENST00000455034, ENST00000454773, ENST00000411944, ENST00000428438, ENST00000430843, ENST00000444068, ENST00000457733, ENST00000426417, ENST00000431966, ENST00000430384, ENST00000411848, ENST00000427701, ENST00000446416, ENST00000445395
Protein	ENSP00000372873, ENSP00000416355, ENSP00000411030, ENSP00000414435, ENSP00000390961, ENSP00000391633, ENSP00000403273, ENSP00000391438, ENSP00000388032, ENSP00000416413, ENSP00000416243, ENSP00000395732, ENSP00000392683, ENSP00000412484, ENSP00000393767, ENSP00000388861, ENSP00000409375, ENSP00000393741, ENSP00000410255, ENSP00000395846, ENSP00000403627, ENSP00000407122, ENSP00000365569, ENSP00000395333, ENSP00000400615, ENSP00000404300, ENSP00000398834, ENSP00000412058, ENSP00000391341, ENSP00000410658, ENSP00000415104, ENSP00000392736, ENSP00000388153, ENSP00000398866, ENSP00000393145, ENSP00000397108, ENSP00000373056, ENSP00000415094, ENSP00000393409, ENSP00000389698, ENSP00000413293, ENSP00000389138, ENSP00000390747, ENSP00000409995, ENSP00000399313, ENSP00000403917, ENSP00000407101, ENSP00000388517, ENSP00000390909, ENSP00000396247, ENSP00000415215, ENSP00000403574, ENSP00000388104

Gene Ontology (GO)

Show/Hide all(59 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001765	Biological process	Membrane raft assembly	IMP	25204797
GO:0001819	Biological process	Positive regulation of cytokine production	IMP	25204797
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IMP	25204797
GO:0002090	Biological process	Regulation of receptor internalization	IMP	21399631
GO:0022617	Biological process	Extracellular matrix disassembly	IMP	21119006
GO:0032092	Biological process	Positive regulation of protein binding	IMP	24046456
GO:0032728	Biological process	Positive regulation of interferon-beta production	IMP	25204797
GO:0033227	Biological process	DsRNA transport	IMP	25204797
GO:0034116	Biological process	Positive regulation of heterotypic cell-cell adhesion	IMP	25204797
GO:0034141	Biological process	Positive regulation of toll-like receptor 3 signaling pathway	IMP	25204797
GO:0034143	Biological process	Regulation of toll-like receptor 4 signaling pathway	IMP	25204797
GO:0034976	Biological process	Response to endoplasmic reticulum stress	IMP	25204797
GO:0044854	Biological process	Plasma membrane raft assembly	IMP	21399631
GO:0045807	Biological process	Positive regulation of endocytosis	IMP	21399631
GO:0048643	Biological process	Positive regulation of skeletal muscle tissue development	IMP	24046456
GO:0050821	Biological process	Protein stabilization	IMP	25204797
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IMP	23319823
GO:0051260	Biological process	Protein homooligomerization	IMP	21399631
GO:0051580	Biological process	Regulation of neurotransmitter uptake	EXP	21399631
GO:0051580	Biological process	Regulation of neurotransmitter uptake	IDA	21399631
GO:0051580	Biological process	Regulation of neurotransmitter uptake	IMP	21399631
GO:0060355	Biological process	Positive regulation of cell adhesion molecule production	IMP	25204797
GO:0070528	Biological process	Protein kinase C signaling	IMP	21399631
GO:0071360	Biological process	Cellular response to exogenous dsRNA	IMP	25204797
GO:0072659	Biological process	Protein localization to plasma membrane	IMP	24046456, 24612608
GO:1901741	Biological process	Positive regulation of myoblast fusion	IMP	24046456
GO:1901890	Biological process	Positive regulation of cell junction assembly	IMP	24046456
GO:1903044	Biological process	Protein localization to membrane raft	IMP	25204797
GO:2000049	Biological process	Positive regulation of cell-cell adhesion mediated by cadherin	IMP	24046456
GO:0001931	Cellular component	Uropod	IDA	21696602
GO:0005765	Cellular component	Lysosomal membrane	HDA	17897319
GO:0005768	Cellular component	Endosome	IDA	20682791
GO:0005769	Cellular component	Early endosome	IDA	21399631
GO:0005815	Cellular component	Microtubule organizing center	IDA	18000879
GO:0005886	Cellular component	Plasma membrane	IDA	21399631
GO:0005886	Cellular component	Plasma membrane	IMP	21696602
GO:0005886	Cellular component	Plasma membrane	TAS	9153235
GO:0005901	Cellular component	Caveola	TAS	9153235
GO:0005911	Cellular component	Cell-cell junction	IDA	25468996
GO:0005913	Cellular component	Cell-cell adherens junction	IDA	24046456
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0008180	Cellular component	COP9 signalosome	IDA	18850735
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016323	Cellular component	Basolateral plasma membrane	IDA	23983584
GO:0016324	Cellular component	Apical plasma membrane	IDA	23983584
GO:0016600	Cellular component	Flotillin complex	IDA	21399631, 21696602, 24046456, 25204797
GO:0030027	Cellular component	Lamellipodium	IDA	24046456
GO:0030864	Cellular component	Cortical actin cytoskeleton	IDA	24046456
GO:0031410	Cellular component	Cytoplasmic vesicle	IDA	23983584
GO:0034451	Cellular component	Centriolar satellite	IDA	18000879
GO:0044291	Cellular component	Cell-cell contact zone	IDA	23983584
GO:0045121	Cellular component	Membrane raft	IDA	15469992, 25893292
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0098691	Cellular component	Dopaminergic synapse	EXP	21399631
GO:0098691	Cellular component	Dopaminergic synapse	IDA	21399631
GO:0098691	Cellular component	Dopaminergic synapse	IMP	21399631
GO:0002020	Molecular function	Protease binding	IPI	24612608
GO:0005515	Molecular function	Protein binding	IPI	15469992, 16480949, 17113085, 21119006, 24167781, 24809731, 30021884, 30614533
GO:0046982	Molecular function	Protein heterodimerization activity	IMP	21696602

Protein Information

Protein Name

Flotillin-1, integral membrane component of caveolae

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles

UniProt

O75955

Pfam

Pfam Accession	Pfam ID
PF01145	Band_7
PF15975	Flot

FLOT1

Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome.