FLT1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

FLT1

Aliases

FLT, FLT-1, VEGFR-1, VEGFR1

Entrez Gene ID

2321

Gene Name

Fms related receptor tyrosine kinase 1

Chromosomal Location

13q12.3

HGNC ID

HGNC:3763

Summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

RefSeq DNA

NG_012003.1

RefSeq mRNA

NM_002019.4, NM_001159920.2, NM_001160030.2, NM_001160031.1

e!Ensembl

Gene	ENSG00000102755
Transcript	ENST00000282397, ENST00000541932, ENST00000615840, ENST00000639477, ENST00000539099, ENST00000615611, ENST00000540678, ENST00000617835, ENST00000543394
Protein	ENSP00000282397, ENSP00000437631, ENSP00000484039, ENSP00000491097, ENSP00000442630, ENSP00000484385, ENSP00000443311, ENSP00000484832, ENSP00000437841

Gene Ontology (GO)

Show/Hide all(42 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002040	Biological process	Sprouting angiogenesis	IBA	21873635
GO:0002548	Biological process	Monocyte chemotaxis	IDA	8605350, 18079407
GO:0007169	Biological process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0008284	Biological process	Positive regulation of cell proliferation	IBA	21873635
GO:0010863	Biological process	Positive regulation of phospholipase C activity	IMP	11312102
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IBA	21873635
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IMP	14633857
GO:0016477	Biological process	Cell migration	IBA	21873635
GO:0016477	Biological process	Cell migration	IMP	8605350
GO:0018108	Biological process	Peptidyl-tyrosine phosphorylation	IDA	9299537, 11513746
GO:0030335	Biological process	Positive regulation of cell migration	IDA	8605350
GO:0030949	Biological process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA	1312256
GO:0035924	Biological process	Cellular response to vascular endothelial growth factor stimulus	IDA	8605350
GO:0036323	Biological process	Vascular endothelial growth factor receptor-1 signaling pathway	IDA	15952180
GO:0043406	Biological process	Positive regulation of MAP kinase activity	IDA	9299537
GO:0043410	Biological process	Positive regulation of MAPK cascade	IBA	21873635
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	9299537
GO:0043552	Biological process	Positive regulation of phosphatidylinositol 3-kinase activity	IMP	11312102
GO:0045766	Biological process	Positive regulation of angiogenesis	IBA	21873635
GO:0045766	Biological process	Positive regulation of angiogenesis	IMP	14633857, 28637396
GO:0046777	Biological process	Protein autophosphorylation	IDA	9299537, 11513746
GO:0048010	Biological process	Vascular endothelial growth factor receptor signaling pathway	IBA	21873635
GO:0048010	Biological process	Vascular endothelial growth factor receptor signaling pathway	IDA	9299537
GO:0048010	Biological process	Vascular endothelial growth factor receptor signaling pathway	IMP	11312102
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:1905563	Biological process	Negative regulation of vascular endothelial cell proliferation	IGI	22955733
GO:0005615	Cellular component	Extracellular space	TAS	8248162
GO:0005887	Cellular component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	IDA	11513746
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0043235	Cellular component	Receptor complex	IBA	21873635
GO:0043235	Cellular component	Receptor complex	IDA	23382219
GO:0004714	Molecular function	Transmembrane receptor protein tyrosine kinase activity	IBA	21873635
GO:0005021	Molecular function	Vascular endothelial growth factor-activated receptor activity	IBA	21873635
GO:0005021	Molecular function	Vascular endothelial growth factor-activated receptor activity	IDA	1312256, 9299537
GO:0005021	Molecular function	Vascular endothelial growth factor-activated receptor activity	IMP	11312102
GO:0005515	Molecular function	Protein binding	IPI	1312256, 7657594, 9393862, 10543948, 12771128, 14684734, 16893970, 18273061, 20660291, 23397142
GO:0019838	Molecular function	Growth factor binding	IPI	1312256, 10471394, 11513746, 12366396, 16109918
GO:0036326	Molecular function	VEGF-A-activated receptor activity	IDA	8605350
GO:0036327	Molecular function	VEGF-B-activated receptor activity	IDA	15952180
GO:0036332	Molecular function	Placental growth factor-activated receptor activity	IDA	12796773
GO:0038085	Molecular function	Vascular endothelial growth factor binding	IBA	21873635

Protein Information

Protein Name

Vascular endothelial growth factor receptor 1, fms related tyrosine kinase 1, fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), tyrosine-protein kinase FRT, tyrosine-protein kinase receptor FLT, vascular permeability factor receptor

Function

Refseq Proteins

NP_002010.2, NP_001153392.1, NP_001153502.1, NP_001153503.1

UniProt

P17948

PDB

1RV6, 5EX3, 1FLT, 1QTY, 5T89, 2XAC, 1QSV, 1QSZ, 3HNG, 4CKV, 4CL7, 5ABD