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Gene Symbol |
FNDC5 |
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Aliases |
FRCP2, irisin |
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Entrez Gene ID |
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Gene Name |
Fibronectin type III domain containing 5 |
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Chromosomal Location |
1p35.1 |
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HGNC ID |
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Summary |
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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e!Ensembl
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| Protein Information |
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Protein Name |
Fibronectin type III domain-containing protein 5, fibronectin type III repeat-containing protein 2 |
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Function |
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[Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000334458 |
P43694 |
P43694 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Liver Fibrosis |
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| Non-alcoholic Fatty Liver Disease |
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| Endocrine System Diseases |
| Diabetes Mellitus |
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| Prediabetes |
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| PCOS |
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| Nutritional and Metabolic Diseases |
| Obesity |
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| Gluocose Intolerance |
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| Renal Disorder |
| Diabetic Nephropathy |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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PCOS, type 2 diabetes, gestational diabetes mellitus |
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2003 Rotterdam ESHRE/ASRM PCOS Consensus Workshop Group diagnostic criteria |
Direct
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57 women with PCOS (25 lean and 32 overweight/obese) and 20 healthy controls (9 lean and 11 overweight/obese) |
The higher serum irisin concentrations at baseline and in response to insulin infusion might be secondary to insulin resistant conditions in PCOS women. |
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