FNDC5

Gene Information
 
Gene Symbol
FNDC5
 
Aliases
FRCP2, irisin
 
Entrez Gene ID
 
Gene Name
Fibronectin type III domain containing 5
 
Chromosomal Location
1p35.1
 
HGNC ID
 
Summary
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0090336 Biological process Positive regulation of brown fat cell differentiation IBA 21873635
GO:0005576 Cellular component Extracellular region IBA 21873635
GO:0005886 Cellular component Plasma membrane IBA 21873635
Protein Information
 
Protein Name
Fibronectin type III domain-containing protein 5, fibronectin type III repeat-containing protein 2
 
Function
[Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF16066 DUF4808
PF00041 fn3
Interactions
 
STRING MINT IntAct
ENSP00000334458 P43694 P43694
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Liver Fibrosis
Non-alcoholic Fatty Liver Disease
Endocrine System Diseases
Diabetes Mellitus
Prediabetes
PCOS
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS, type 2 diabetes, gestational diabetes mellitus 
 
2003 Rotterdam ESHRE/ASRM PCOS Consensus Workshop Group diagnostic criteria 
Direct 
57 women with PCOS (25 lean and 32 overweight/obese) and 20 healthy controls (9 lean and 11 overweight/obese) 
The higher serum irisin concentrations at baseline and in response to insulin infusion might be secondary to insulin resistant conditions in PCOS women. 

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412