FOS: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

FOS

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

FOS

Aliases

AP-1, C-FOS, p55

Entrez Gene ID

2353

Gene Name

Fos proto-oncogene, AP-1 transcription factor subunit

Chromosomal Location

14q24.3

HGNC ID

HGNC:3796

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_029673.1

RefSeq mRNA

NM_005252.4

e!Ensembl

Gene	ENSG00000170345
Transcript	ENST00000303562, ENST00000554617, ENST00000554212, ENST00000535987, ENST00000555242, ENST00000555686, ENST00000555672, ENST00000557139, ENST00000555347
Protein	ENSP00000306245, ENSP00000450519, ENSP00000452443, ENSP00000442268, ENSP00000452386, ENSP00000452590, ENSP00000452440, ENSP00000451786, ENSP00000450886

Gene Ontology (GO)

Show/Hide all(29 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006306	Biological process	DNA methylation	TAS	9888853
GO:0006357	Biological process	Regulation of transcription by RNA polymerase II	TAS	10918580
GO:0006954	Biological process	Inflammatory response	TAS	9443941
GO:0007179	Biological process	Transforming growth factor beta receptor signaling pathway	IDA	9732876
GO:0034614	Biological process	Cellular response to reactive oxygen species	IDA	17217916
GO:0034614	Biological process	Cellular response to reactive oxygen species	IMP	26514923
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	9732876
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	26514923
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	10508860
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IGI	10523647
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IMP	10704222
GO:0060395	Biological process	SMAD protein signal transduction	IDA	9732876
GO:0071276	Biological process	Cellular response to cadmium ion	IMP	26514923
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	22387553, 24184327
GO:0032993	Cellular component	Protein-DNA complex	IMP	10704222
GO:0035976	Cellular component	Transcription factor AP-1 complex	IDA	10508860
GO:0035976	Cellular component	Transcription factor AP-1 complex	IMP	26514923
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IBA	21873635
GO:0000979	Molecular function	RNA polymerase II core promoter sequence-specific DNA binding	IMP	10704222
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0001102	Molecular function	RNA polymerase II activating transcription factor binding	IPI	10508860
GO:0003700	Molecular function	DNA-binding transcription factor activity	IDA	9732876
GO:0003700	Molecular function	DNA-binding transcription factor activity	IMP	10704222
GO:0005515	Molecular function	Protein binding	IPI	7816143, 12788789, 16511568, 18172215, 19028685, 19064921, 20102225, 20195357, 20511396, 20936779, 21199371, 22308434, 23602568, 24029232, 25241761, 25609649, 26496610, 29997244
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IDA	9732876
GO:0046982	Molecular function	Protein heterodimerization activity	IDA	10508860
GO:0070412	Molecular function	R-SMAD binding	IPI	9732876

Protein Information

Protein Name

Proto-oncogene c-Fos, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, Fos proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 7, activator protein 1, cellular oncogene c-fos

Function

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Refseq Proteins

NP_005243.1

UniProt

P01100

PDB

1A02, 1FOS, 1S9K

Pfam

Pfam Accession	Pfam ID
PF00170	bZIP_1

Pathways
	KEGG	Reactome
	Endocrine resistance MAPK signaling pathway cAMP signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Circadian entrainment Cholinergic synapse Dopaminergic synapse Estrogen signaling pathway Prolactin signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Amphetamine addiction Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease (American trypanosomiasis) Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Colorectal cancer Breast cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Rheumatoid arthritis Fluid shear stress and atherosclerosis	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Interactions

STRING	MINT	IntAct
ENSP00000421725	P02774	P02774

View interactions

Associated Diseases

Show/Hide all(11 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Hypertensive disease	12044476, 24039778
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Atonic seizures	9630518, 12946577, 8923670, 11955713
Digestive System Diseases
Digestive System Diseases	Cholestasis	28789951
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
Endocrine System Diseases	PCOS	27997581
Immune System Diseases
	Juvenile arthritis	19565504
	Still Disease	19565504
Musculoskeletal Diseases
Musculoskeletal Diseases	Osteitis Fibrosa Disseminata	7739708
Neoplasms
	Lung Cancer	16289808
	Breast Cancer	16298037
	Liver Cancer	9029167
	Vulvar Cancer	15365562
Nervous System Diseases
	Status Epilepticus	7984056, 18587450, 18988310, 16696126
	Seizures	8923670, 11955713, 12946577, 9630518
	Trigeminal neuralgia	27093858
	Jacksonian Seizure	12946577, 11955713, 9630518, 8923670
	Petit mal status	18988310, 16696126, 7984056, 18587450
	Middle Cerebral Artery Syndrome	12374626
	Lateral Sclerosis	11796754
	Cerebral Artery Infarction	12374626
	Brain Infarction	12374626
	Cerebral Thrombosis	12374626
	Epilepsy	15973680
Psychiatric/Brain disorders
	Mental Depression	23668904
	Anxiety Disorders	16488545
Reproductive disorders
	Endometriosis	23284138
	Endometrioma	23284138

References

PMID: 27997581

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells.

Aydos Alp, Gurel Aykut, Oztemur Islakoglu Yasemin, Noyan Senem, Gokce Bagdagul, Ecemis Tolga, Kaya Cemil, Aksu Arif Tarik, Gur Dedeoglu Bala

Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, Medicana International Ankara Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, Liv Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, TOBB ETU Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.

PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875.

Statistics

About BIC

Feedback

Links

Contact Us

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412