Gene Information
Gene Symbol
AP-1, C-FOS, p55
Entrez Gene ID
Gene Name
Fos proto-oncogene, AP-1 transcription factor subunit
Chromosomal Location
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0006306 Biological process DNA methylation TAS 9888853
GO:0006357 Biological process Regulation of transcription by RNA polymerase II TAS 10918580
GO:0006954 Biological process Inflammatory response TAS 9443941
GO:0007179 Biological process Transforming growth factor beta receptor signaling pathway IDA 9732876
GO:0034614 Biological process Cellular response to reactive oxygen species IDA 17217916
Protein Information
Protein Name
Proto-oncogene c-Fos, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, Fos proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 7, activator protein 1, cellular oncogene c-fos
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Refseq Proteins
Pfam Accession Pfam ID
PF00170 bZIP_1

Endocrine resistance
MAPK signaling pathway
cAMP signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Circadian entrainment
Cholinergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Prolactin signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
Amphetamine addiction
Salmonella infection
Yersinia infection
Chagas disease (American trypanosomiasis)
Hepatitis B
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Colorectal cancer
Breast cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Rheumatoid arthritis
Fluid shear stress and atherosclerosis


Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of DNA Repair Genes
Estrogen-dependent gene expression
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling

ENSP00000421725 P02774 P02774
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Hypertensive disease
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Atonic seizures
Digestive System Diseases
Ear Or Mastoid Diseases
Meniere Disease
Endocrine System Diseases

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells.

Aydos Alp, Gurel Aykut, Oztemur Islakoglu Yasemin, Noyan Senem, Gokce Bagdagul, Ecemis Tolga, Kaya Cemil, Aksu Arif Tarik, Gur Dedeoglu Bala
Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, Medicana International Ankara Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, Liv Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, TOBB ETU Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.
PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875.

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412