Gene Information
Gene Symbol
Entrez Gene ID
Gene Name
Frizzled class receptor 3
Chromosomal Location
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0035567 Biological process Non-canonical Wnt signaling pathway IBA 21873635
GO:0060070 Biological process Canonical Wnt signaling pathway IBA 21873635
GO:0060070 Biological process Canonical Wnt signaling pathway IDA 20802536
GO:0060071 Biological process Wnt signaling pathway, planar cell polarity pathway NAS 24431302
GO:1904693 Biological process Midbrain morphogenesis TAS 24431302
Protein Information
Protein Name
Frizzled-3, frizzled 3, seven transmembrane spanning receptor, frizzled family receptor 3, frizzled homolog 3
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).
Refseq Proteins
Pfam Accession Pfam ID
PF01534 Frizzled
PF01392 Fz

mTOR signaling pathway
Wnt signaling pathway
Axon guidance
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Cushing syndrome
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer


Ca2+ pathway
PCP/CE pathway
Asymmetric localization of PCP proteins

ENSP00000378408 P24298
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
Psychiatric/Brain disorders
Non-organic psychosis
Mood Disorders
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
PCOS, estrogen deficiency, hyperandrogenemia, obesity, insulin resistance, lipid disorders,menstrual irregularity, failure of oocyte-follicle maturation, anovulation, female infertility  
Rotterdam criteria 
27 PCOS patients 
In PCOS CCs, FZD3 overexpression results in the abnormal accumulation of ?-Catenin and eventually desensitizes FSH-potentiated CCs steroidogenesis. 

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