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Gene Symbol |
FZD5 |
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Aliases |
C2orf31, HFZ5 |
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Entrez Gene ID |
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Gene Name |
Frizzled class receptor 5 |
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Chromosomal Location |
2q33.3 |
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HGNC ID |
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Summary |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0000578 |
Biological process |
Embryonic axis specification |
IDA |
12121999 |
| GO:0002726 |
Biological process |
Positive regulation of T cell cytokine production |
IDA |
16601243 |
| GO:0007416 |
Biological process |
Synapse assembly |
TAS |
24449494 |
| GO:0008595 |
Biological process |
Anterior/posterior axis specification, embryo |
IDA |
9054360 |
| GO:0032729 |
Biological process |
Positive regulation of interferon-gamma production |
IMP |
16601243 |
| GO:0035567 |
Biological process |
Non-canonical Wnt signaling pathway |
IBA |
21873635 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IDA |
12857724 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IGI |
10906785 |
| GO:0060061 |
Biological process |
Spemann organizer formation |
IDA |
9054360 |
| GO:0060070 |
Biological process |
Canonical Wnt signaling pathway |
IBA |
21873635 |
| GO:0060070 |
Biological process |
Canonical Wnt signaling pathway |
IDA |
11029007, 12121999, 12857724, 15459103, 24080158, 28733458 |
| GO:0060070 |
Biological process |
Canonical Wnt signaling pathway |
IMP |
9054360 |
| GO:0071219 |
Biological process |
Cellular response to molecule of bacterial origin |
IDA |
16601243 |
| GO:1903146 |
Biological process |
Regulation of autophagy of mitochondrion |
HMP |
24912190 |
| GO:1903955 |
Biological process |
Positive regulation of protein targeting to mitochondrion |
HMP |
24912190 |
| GO:0005886 |
Cellular component |
Plasma membrane |
IBA |
21873635 |
| GO:0005887 |
Cellular component |
Integral component of plasma membrane |
IDA |
15459103 |
| GO:0009986 |
Cellular component |
Cell surface |
IDA |
19643732 |
| GO:0001540 |
Molecular function |
Amyloid-beta binding |
IPI |
18234671 |
| GO:0001540 |
Molecular function |
Amyloid-beta binding |
TAS |
24449494 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
18838381, 19643732, 22895187 |
| GO:0017147 |
Molecular function |
Wnt-protein binding |
IBA |
21873635 |
| GO:0017147 |
Molecular function |
Wnt-protein binding |
IPI |
12490564, 12857724, 18174455 |
| GO:0017147 |
Molecular function |
Wnt-protein binding |
TAS |
18234671 |
| GO:0019901 |
Molecular function |
Protein kinase binding |
IPI |
19643732 |
| GO:0031625 |
Molecular function |
Ubiquitin protein ligase binding |
IPI |
22575959 |
| GO:0042813 |
Molecular function |
Wnt-activated receptor activity |
IBA |
21873635 |
| GO:0042813 |
Molecular function |
Wnt-activated receptor activity |
IC |
9054360 |
| GO:0042813 |
Molecular function |
Wnt-activated receptor activity |
IDA |
15459103, 28733458 |
| GO:0042813 |
Molecular function |
Wnt-activated receptor activity |
TAS |
24449494 |
| GO:0044877 |
Molecular function |
Protein-containing complex binding |
IPI |
18234671 |
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| Protein Information |
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Protein Name |
Frizzled-5, Wnt receptor, frizzled 5, seven transmembrane spanning receptor, frizzled family receptor 5, fz-5, fzE5, seven-transmembrane receptor frizzled-5 |
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Function |
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Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000313432 |
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Q9UBQ7 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Blood Disorders |
| Anemia |
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| Cardiovascular Diseases |
| Pulmonary Hypertension |
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| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Congenital Ocular Coloboma |
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| Bladder Exstrophy |
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| Digestive System Diseases |
| Fatty Liver |
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| Alcoholic fatty liver |
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| Inflammatory Bowel Diseases |
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| Endocrine System Diseases |
| PCOS |
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| Eye Diseases |
| Myopia |
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| Retinitis Pigmentosa |
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| Musculoskeletal Diseases |
| Osteoarthritis |
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| Osteoporosis |
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| Neoplasms |
| Colorectal Cancer |
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| Pancreatic Cyst |
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| Myeloid Leukemia |
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| Gastrointestinal Cancer |
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| Prostate cancer |
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| Gastric Cancer |
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| Pancreatic Neoplasm |
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| Neuroendocrine Tumor |
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| Ovarian Cysts |
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| Carcinoma |
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| Lymphangioma |
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| Renal Cancer |
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| Endometrial Cancer |
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| Skin and Connective Tissue Diseases |
| Psoriasis |
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| Scleroderma |
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References |
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| Aydos Alp, Gurel Aykut, Oztemur Islakoglu Yasemin, Noyan Senem, Gokce Bagdagul, Ecemis Tolga, Kaya Cemil, Aksu Arif Tarik, Gur Dedeoglu Bala |
| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, Medicana International Ankara Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, Liv Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, TOBB ETU Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey. |
| PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875. |
Abstract
Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with prevalence of 8-18%. The oocyte within the follicle is surrounded by cumulus cells (CCs), which connect with mural granulosa cells (MGCs) that are responsible for secreting steroid hormones. The main aim of this study is comparing gene expression profiles of MGCs and CCs in PCOS and control samples to identify PCOS-specific differentially expressed genes (DEGs). In this study, two microarray databases were searched for mRNA expression microarray studies performed with CCs and MGCs obtained from PCOS patients and control samples. Three independent studies were selected to be integrated with naive meta-analysis since raw meta-data from these studies were found to be highly correlated. DEGs in these somatic cells were identified for PCOS and control groups. This study enabled us to reveal dysregulation in MAPK (mitogen activated protein kinase), insulin and Wnt signaling pathways between CCs and MGCs in PCOS. The meta-analysis results together with qRT-PCR validations provide evidence that molecular signaling is dysregulated through MGCs and CCs in PCOS, which is important for follicle and oocyte maturation and may contribute to the pathogenesis of the syndrome. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
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