GHRH

Gene Information
 
Gene Symbol
GHRH
 
Aliases
GHRF, GRF, INN
 
Entrez Gene ID
 
Gene Name
Growth hormone releasing hormone
 
Chromosomal Location
20q11.23
 
HGNC ID
 
Summary
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0007189 Biological process Adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007189 Biological process Adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA 1333056, 3008329, 7680413
GO:0007267 Biological process Cell-cell signaling TAS 6192430
GO:0008284 Biological process Positive regulation of cell proliferation IBA 21873635
GO:0008284 Biological process Positive regulation of cell proliferation IDA 12867592
Protein Information
 
Protein Name
Somatoliberin, growth hormone releasing factor, sermorelin, somatocrinin, somatorelin
 
Function
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00123 Hormone_2
Pathways
 
KEGG
 
Reactome
 

Neuroactive ligand-receptor interaction

 

G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production

Interactions
 
STRING MINT IntAct
ENSP00000255030 P02741 P02741
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
PCOS
Respiratory Tract Diseases
Pulmonary Edema
References
 
PMID: 8959075

Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome.

Micic D, Kendereski A, Popovic V, Sumarac M, Zoric S, Macut D, Dieguez C, Casanueva F
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Beograd, Yugoslavia.
Clin Endocrinol (Oxf). 1996 Oct;45(4):385-90.

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