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Gene Symbol |
GIP |
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Aliases |
- |
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Entrez Gene ID |
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Gene Name |
Gastric inhibitory polypeptide |
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Chromosomal Location |
17q21.32 |
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HGNC ID |
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Summary |
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
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e!Ensembl
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| Protein Information |
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Protein Name |
Gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide, incretin hormone |
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Function |
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Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00123 |
Hormone_2 |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000257863 |
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Q16671 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Arteriosclerosis |
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| Endocrine System Diseases |
| PCOS |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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GLP-1,C-peptide |
Insulin resistance,type 2 diabetes |
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Related
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Increased insulinotropic effect could counteract the blunted GIP response to OGTT in obese women with PCOS. |
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GLP-1,C-peptide |
Type 2 diabetes |
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Related
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Increased total GIP and lower late phase active GLP-1 concentrations during OGTT characterize PCOS women with higher C-peptide secretion in comparison with healthy controls, and may be the early markers of a pre-diabetic state. |
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