GLP1R: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

GLP1R

Aliases

GLP-1, GLP-1-R, GLP-1R

Entrez Gene ID

2740

Gene Name

Glucagon like peptide 1 receptor

Chromosomal Location

6p21.2

HGNC ID

HGNC:4324

Summary

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

e!Ensembl

Gene	ENSG00000112164
Transcript	ENST00000373256
Protein	ENSP00000362353

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
rs10305420					25991051

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007189	Biological process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	28514449
GO:0007190	Biological process	Activation of adenylate cyclase activity	TAS	8405712
GO:0007204	Biological process	Positive regulation of cytosolic calcium ion concentration	IDA	7589461
GO:0019933	Biological process	CAMP-mediated signaling	IDA	7589461
GO:0045777	Biological process	Positive regulation of blood pressure	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	IDA	28514449
GO:0016021	Cellular component	Integral component of membrane	TAS	8405712
GO:0004888	Molecular function	Transmembrane signaling receptor activity	TAS	8405712
GO:0005515	Molecular function	Protein binding	IPI	25416956
GO:0008528	Molecular function	G protein-coupled peptide receptor activity	IBA	21873635
GO:0017046	Molecular function	Peptide hormone binding	IBA	21873635
GO:0044508	Molecular function	Glucagon-like peptide 1 receptor activity	IDA	28514449

Protein Information

Protein Name

Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP1 receptor, seven transmembrane helix receptor

Function

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

UniProt

P43220

PDB

6B3J, 3C59, 3C5T, 3IOL, 4ZGM, 5E94, 5NX2, 5OTT, 5OTU, 5OTV, 5OTW, 5OTX, 5VEW, 5VEX, 6GB1

Pfam

Pfam Accession	Pfam ID
PF00002	7tm_2
PF02793	HRM