GPC4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

GPC4

Aliases

K-glypican, KPTS

Entrez Gene ID

2239

Gene Name

Glypican 4

Chromosomal Location

Xq26.2

HGNC ID

HGNC:4452

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012498.1

RefSeq mRNA

NM_001448.3

e!Ensembl

Gene	ENSG00000076716
Transcript	ENST00000370828
Protein	ENSP00000359864

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0016477	Biological process	Cell migration	IBA	21873635
GO:0098696	Biological process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IBA	21873635
GO:0099560	Biological process	Synaptic membrane adhesion	IBA	21873635
GO:1905475	Biological process	Regulation of protein localization to membrane	IBA	21873635
GO:1905606	Biological process	Regulation of presynapse assembly	IBA	21873635
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0009897	Cellular component	External side of plasma membrane	IDA	10585884
GO:0009986	Cellular component	Cell surface	IBA	21873635
GO:0045202	Cellular component	Synapse	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708
GO:1904929	Molecular function	Coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	NAS	24431302

Protein Information

Protein Name

Glypican-4, dJ900E8.1 (glypican 4), glypican proteoglycan 4

Function

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).

Refseq Proteins

NP_001439.2

UniProt

O75487

Pfam

Pfam Accession	Pfam ID
PF01153	Glypican