GSK3B: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

GSK3B

Aliases

Entrez Gene ID

2932

Gene Name

Glycogen synthase kinase 3 beta

Chromosomal Location

3q13.33

HGNC ID

HGNC:4617

Summary

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

RefSeq DNA

NG_012922.1

RefSeq mRNA

NM_002093.4, NM_001146156.2, NM_001354596.2

e!Ensembl

Gene	ENSG00000082701
Transcript	ENST00000264235, ENST00000316626, ENST00000650344
Protein	ENSP00000264235, ENSP00000324806, ENSP00000497956

SNPs

Show/Hide all(9)

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
rs6805251	ACTAATTAAACTAATAAAGTTCAAAT	A/C/G/T	ACTTTCTCAAGGTAGCATGTGCTGA		17270183
rs1719889	TATTCCTCTACCACTTGGCTAGATTA	A/T	GTGAGAATGGTAGCTTTGTAGGGAG	Intron variant	17270183
rs1719895	ccaacacatgagctttgggggacata	C/T	tcaaatcatggcaCTGCTCTATTTA	Intron variant	17270183
rs7624540	ctttggaaaatagtttggtaaccata	A/C	acttaccatatgatcagcaatttca	Intron variant	17270183
rs2319398	attctatttatattaaatgtccagaa	G/T	agacagattgtggagacaaaaagat	Intron variant	17270183
rs7620750	TTGAGAATCACCATGTTCAAGCATAG	A/G	CTTGGCTACTGAGTGAGAAATACTG	Intron variant	17270183
rs1381841	CTTGGGCATATGTTTTATAGAAATAG	A/G	AATTTACGTTCACATTAAAACCGGC	Intron variant	17270183
rs6770314	CACCTTCCTGAAACAAATTGTGACCC	A/G	CGTAGGCAATATGCCCCATTATTTA	Intron variant	17270183
rs2199503	GCATAGCCTTTTGGGTGAGGAAGTTG	A/G	ACTAAGATTTCAGAGCTCTCTTGCT	Intron variant	17270183

Gene Ontology (GO)

Show/Hide all(71 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001837	Biological process	Epithelial to mesenchymal transition	IMP	15448698
GO:0001954	Biological process	Positive regulation of cell-matrix adhesion	IMP	18156211
GO:0005977	Biological process	Glycogen metabolic process	IDA	8638126
GO:0006468	Biological process	Protein phosphorylation	IDA	11035810, 16315267, 20937854
GO:0006468	Biological process	Protein phosphorylation	IMP	16981698
GO:0006468	Biological process	Protein phosphorylation	TAS	26049140
GO:0006983	Biological process	ER overload response	IDA	14744935
GO:0007212	Biological process	Dopamine receptor signaling pathway	NAS	21711983
GO:0010822	Biological process	Positive regulation of mitochondrion organization	IMP	25118933
GO:0018105	Biological process	Peptidyl-serine phosphorylation	IDA	8638126, 11104755, 11955436, 14744935, 17139249
GO:0018107	Biological process	Peptidyl-threonine phosphorylation	IDA	11955436, 17139249, 25897075
GO:0021766	Biological process	Hippocampus development	IMP	19581563
GO:0030010	Biological process	Establishment of cell polarity	TAS	18268107
GO:0030011	Biological process	Maintenance of cell polarity	TAS	18268107
GO:0031175	Biological process	Neuron projection development	IDA	19830702
GO:0031333	Biological process	Negative regulation of protein complex assembly	IMP	16188939
GO:0031334	Biological process	Positive regulation of protein complex assembly	IDA	8638126
GO:0032091	Biological process	Negative regulation of protein binding	IDA	16890161
GO:0032436	Biological process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IC	11955436
GO:0032436	Biological process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	25897075
GO:0032515	Biological process	Negative regulation of phosphoprotein phosphatase activity	TAS	28386764
GO:0032886	Biological process	Regulation of microtubule-based process	IMP	20937854
GO:0035556	Biological process	Intracellular signal transduction	IDA	14749367
GO:0035556	Biological process	Intracellular signal transduction	TAS	26049140
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	14744935
GO:0043547	Biological process	Positive regulation of GTPase activity	IMP	18156211
GO:0045719	Biological process	Negative regulation of glycogen biosynthetic process	TAS	19366350
GO:0045732	Biological process	Positive regulation of protein catabolic process	IC	16188939
GO:0046777	Biological process	Protein autophosphorylation	IDA	23184662
GO:0046827	Biological process	Positive regulation of protein export from nucleus	IDA	14744935
GO:0060079	Biological process	Excitatory postsynaptic potential	NAS	21711983
GO:0070885	Biological process	Negative regulation of calcineurin-NFAT signaling cascade	IMP	9072970
GO:0071109	Biological process	Superior temporal gyrus development	IMP	19581563
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IC	9601641, 11955436
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	TAS	19366350
GO:1901215	Biological process	Negative regulation of neuron death	IDA	19830702
GO:1901216	Biological process	Positive regulation of neuron death	IDA	18508033
GO:1904339	Biological process	Negative regulation of dopaminergic neuron differentiation	TAS	24431302
GO:1904781	Biological process	Positive regulation of protein localization to centrosome	IMP	17139249
GO:2000077	Biological process	Negative regulation of type B pancreatic cell development	TAS	19366350
GO:2000300	Biological process	Regulation of synaptic vesicle exocytosis	EXP	17989287
GO:2000300	Biological process	Regulation of synaptic vesicle exocytosis	IDA	17989287
GO:2000466	Biological process	Negative regulation of glycogen (starch) synthase activity	TAS	19366350
GO:0005634	Cellular component	Nucleus	IDA	14744935, 15448698
GO:0005737	Cellular component	Cytoplasm	IDA	14744935, 15448698, 18787224, 19038973, 20937854
GO:0005813	Cellular component	Centrosome	IDA	17139249, 21399614
GO:0005886	Cellular component	Plasma membrane	IDA	20937854
GO:0030877	Cellular component	Beta-catenin destruction complex	IDA	8638126, 9601641, 16188939
GO:0030877	Cellular component	Beta-catenin destruction complex	TAS	11955436, 19366350
GO:0098978	Cellular component	Glutamatergic synapse	EXP	17989287
GO:0098978	Cellular component	Glutamatergic synapse	IDA	17989287
GO:1990909	Cellular component	Wnt signalosome	TAS	24115276
GO:0001085	Molecular function	RNA polymerase II transcription factor binding	IPI	20864106
GO:0002020	Molecular function	Protease binding	IPI	25118933
GO:0002039	Molecular function	P53 binding	IDA	14744935
GO:0004672	Molecular function	Protein kinase activity	IMP	16981698
GO:0004672	Molecular function	Protein kinase activity	TAS	22988876, 24115276, 26049140
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IDA	8638126, 9072970, 11035810, 11104755, 11955436, 14744935, 16315267, 17139249, 18348280
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IMP	16981698
GO:0004674	Molecular function	Protein serine/threonine kinase activity	NAS	8725894, 28386764
GO:0005515	Molecular function	Protein binding	IPI	8638126, 9482734, 9601641, 9731200, 10481074, 11004522, 11035810, 11738041, 12421363, 12434148, 12927815, 14744935, 15147888, 15448698, 15752768, 16282323, 16365045, 16890161, 16981698, 17078951, 17139249, 17317006, 17318191, 17510365, 17601533, 18045539, 18505846, 18687691, 1913197
GO:0008013	Molecular function	Beta-catenin binding	IPI	8638126
GO:0016301	Molecular function	Kinase activity	IDA	15448698, 24391509
GO:0019901	Molecular function	Protein kinase binding	IPI	18348280
GO:0031625	Molecular function	Ubiquitin protein ligase binding	IPI	21118991
GO:0034236	Molecular function	Protein kinase A catalytic subunit binding	IPI	11035810
GO:0034452	Molecular function	Dynactin binding	IPI	17139249
GO:0048156	Molecular function	Tau protein binding	NAS	28386764
GO:0050321	Molecular function	Tau-protein kinase activity	IDA	14690523, 16365045
GO:0050321	Molecular function	Tau-protein kinase activity	NAS	28386764
GO:0051059	Molecular function	NF-kappaB binding	IPI	15465828

Protein Information

Protein Name

Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3beta isoform, serine/threonine-protein kinase GSK3B

Function

Refseq Proteins

NP_002084.2, NP_001139628.1, NP_001341525.1

UniProt

P49841

PDB

3CQU, 3CQW, 3MV5, 3OW4, 3QKK, 4EKK, 6BUU, 6NPZ, 1O6K, 1O6L, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3E87, 3E88, 3E8D, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ, 5OY4, 1H8F, 1I09, 1J1B, 1J1C, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JLD, 2O5K, 2OW3, 3DU8, 3F7Z, 3F88, 3GB2, 3I4B,

Pfam

Pfam Accession	Pfam ID
PF00069	Pkinase