GSTM3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

GSTM3

Aliases

GST5, GSTB, GSTM3-3, GTM3

Entrez Gene ID

2947

Gene Name

Glutathione S-transferase mu 3

Chromosomal Location

1p13.3

HGNC ID

HGNC:4635

Summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

e!Ensembl

Gene	ENSG00000134202
Transcript	ENST00000361066, ENST00000256594, ENST00000540225
Protein	ENSP00000354357, ENSP00000256594, ENSP00000444978

Gene Ontology (GO)

Show/Hide all(20 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006749	Biological process	Glutathione metabolic process	IBA	21873635
GO:0006749	Biological process	Glutathione metabolic process	IDA	8373352, 10587441
GO:0008065	Biological process	Establishment of blood-nerve barrier	TAS	2345169
GO:0018916	Biological process	Nitrobenzene metabolic process	IDA	8373352
GO:0042178	Biological process	Xenobiotic catabolic process	IBA	21873635
GO:0042178	Biological process	Xenobiotic catabolic process	IDA	8373352
GO:0043627	Biological process	Response to estrogen	IEP	10037815
GO:0070458	Biological process	Cellular detoxification of nitrogen compound	IDA	8373352
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0005737	Cellular component	Cytoplasm	IDA	8373352
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0004364	Molecular function	Glutathione transferase activity	IBA	21873635
GO:0004364	Molecular function	Glutathione transferase activity	IDA	8373352, 9545290, 10587441
GO:0005515	Molecular function	Protein binding	IPI	23355646
GO:0019899	Molecular function	Enzyme binding	IPI	8373352
GO:0042802	Molecular function	Identical protein binding	IPI	16189514, 19060904, 21516116
GO:0042803	Molecular function	Protein homodimerization activity	IDA	9545290
GO:0042803	Molecular function	Protein homodimerization activity	IPI	8373352
GO:0043295	Molecular function	Glutathione binding	IDA	8373352

Protein Information

Protein Name

Glutathione S-transferase Mu 3, GST class-mu 3, S-(hydroxyalkyl)glutathione lyase M3, brain GST, brain type mu-glutathione S-transferase, epididymis secretory sperm binding protein, glutathione S-alkyltransferase M3, glutathione S-aralkyltransferase M3, glutathione S-aryltransferase M3, glutathione S-transferase M3 (brain), glutathione S-transferase mu 3 (brain), glutathione S-transferase, Mu-3, hGSTM3-3

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

UniProt

P21266

PDB

3GTU

Pfam

Pfam Accession	Pfam ID
PF00043	GST_C
PF02798	GST_N