GSTP1: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

GSTP1

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

GSTP1

Aliases

DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI

Entrez Gene ID

2950

Gene Name

Glutathione S-transferase pi 1

Chromosomal Location

11q13.2

HGNC ID

HGNC:4638

Summary

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012075.1

RefSeq mRNA

NM_000852.4, NM_000852.3

e!Ensembl

Gene	ENSG00000084207
Transcript	ENST00000398606, ENST00000398603, ENST00000646888, ENST00000498765, ENST00000495996
Protein	ENSP00000381607, ENSP00000381604, ENSP00000494477, ENSP00000484929, ENSP00000484686

Gene Ontology (GO)

Show/Hide all(34 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002674	Biological process	Negative regulation of acute inflammatory response	NAS	18962899
GO:0006469	Biological process	Negative regulation of protein kinase activity	IDA	16636664
GO:0006749	Biological process	Glutathione metabolic process	IBA	21873635
GO:0006749	Biological process	Glutathione metabolic process	IDA	1540159
GO:0006805	Biological process	Xenobiotic metabolic process	IDA	1540159
GO:0007417	Biological process	Central nervous system development	TAS	9802272
GO:0009890	Biological process	Negative regulation of biosynthetic process	IDA	18962899
GO:0010804	Biological process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IC	16636664
GO:0032691	Biological process	Negative regulation of interleukin-1 beta production	IDA	18962899
GO:0032720	Biological process	Negative regulation of tumor necrosis factor production	IDA	18962899
GO:0035732	Biological process	Nitric oxide storage	NAS	12871931
GO:0042178	Biological process	Xenobiotic catabolic process	IBA	21873635
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	16130169
GO:0043407	Biological process	Negative regulation of MAP kinase activity	IDA	11408560
GO:0043409	Biological process	Negative regulation of MAPK cascade	NAS	18962899
GO:0043508	Biological process	Negative regulation of JUN kinase activity	IDA	16636664
GO:0043651	Biological process	Linoleic acid metabolic process	IDA	16624487
GO:0051771	Biological process	Negative regulation of nitric-oxide synthase biosynthetic process	IDA	18962899
GO:0070373	Biological process	Negative regulation of ERK1 and ERK2 cascade	IDA	11408560
GO:0071638	Biological process	Negative regulation of monocyte chemotactic protein-1 production	IDA	18962899
GO:2001237	Biological process	Negative regulation of extrinsic apoptotic signaling pathway	IDA	16636664
GO:0005615	Cellular component	Extracellular space	HDA	22664934, 23580065
GO:0005737	Cellular component	Cytoplasm	TAS	16130169
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0031982	Cellular component	Vesicle	HDA	19190083
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0097057	Cellular component	TRAF2-GSTP1 complex	IDA	16636664
GO:0004364	Molecular function	Glutathione transferase activity	IBA	21873635
GO:0004364	Molecular function	Glutathione transferase activity	IDA	1540159
GO:0004602	Molecular function	Glutathione peroxidase activity	IDA	16624487
GO:0005515	Molecular function	Protein binding	IPI	16636664, 23164639, 24965446, 25241761, 25416956
GO:0035730	Molecular function	S-nitrosoglutathione binding	IDA	11533048
GO:0035731	Molecular function	Dinitrosyl-iron complex binding	IDA	11533048, 12871945
GO:0070026	Molecular function	Nitric oxide binding	NAS	11533048

Protein Information

Protein Name

Glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Refseq Proteins

NP_000843.1

UniProt

P09211

PDB

1LBK, 10GS, 11GS, 12GS, 13GS, 14GS, 16GS, 17GS, 18GS, 19GS, 1AQV, 1AQW, 1AQX, 1EOG, 1EOH, 1GSS, 1KBN, 1MD3, 1MD4, 1PGT, 1PX6, 1PX7, 1ZGN, 20GS, 22GS, 2A2R, 2A2S, 2GSS, 2J9H, 2PGT, 3CSH, 3CSI, 3CSJ, 3DD3, 3DGQ, 3GSS, 3GUS, 3HJM, 3HJO, 3HKR, 3IE3, 3KM6, 3KMN, 3KMO, 3N9J, 3PGT, 4GSS, 4PGT, 5DAK, 5DAL, 5DCG,

Pfam

Pfam Accession	Pfam ID
PF14497	GST_C_3
PF02798	GST_N

Pathways
	KEGG	Reactome
	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis Prostate cancer Hepatocellular carcinoma Fluid shear stress and atherosclerosis	Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation

Interactions

STRING	MINT	IntAct
ENSP00000257555	P20823	P20823

View interactions

Associated Diseases

Show/Hide all(10 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Hypertensive disease	24915237
	Myocardial Ischemia	16214533
	Acute Coronary Syndrome	21751358
Digestive System Diseases
	Non-alcoholic Fatty Liver Disease	23643483
	Liver Diseases	25226513, 20623750
	Hepatitis	25226513, 20623750
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Vestibular disorder	18776599
Endocrine System Diseases
Endocrine System Diseases	PCOS	23527552
Neoplasms
	Prostate cancer	22581815, 15538743, 17173048, 11196146, 19223546
	Stomach Cancer	21133646, 21364753
	Glioma	16899598
	Anaplastic Carcinoma	11196146
	Bladder Cancer	7729958, 12500666, 22306368
	Breast Cancer	25322848
	Carotid Atherosclerosis	16973168
	Myeloid Leukemia	20843134
	Lung Cancer	17909032, 17094902
	Prostatic Intraepithelial Neoplasias	22581815
	Gastric Cancer	21364753, 21133646
	Sarcoma	17152492
	Renal Cancer	15108329
	Lymphoma	11406608
	Carcinoma	11196146
	Hodgkin Disease	11406608
	Osteosarcoma	17152492
	Liver Cancer	9029167
	Vulvar Cancer	19047905
Nervous System Diseases
	Tremor	18215156
	Carotid Artery Diseases	16973168
	Moyamoya disease	16973168
	Neuropathy	20979931
	Lateral Sclerosis	16109392
	Parkinson Disease	23721876, 17190945
Psychiatric/Brain disorders
	Schizophrenia	12691788, 25358668
	Psychosis	15729709
	Non-organic psychosis	15729709
	Shared Paranoid Disorder	15729709
	Autistic Disorder	17404132
Renal Disorder
	Ureteral Calculi	24360074
	Kidney Failure	20623750
	Kidney Calculi	24360074
	Kidney Insufficiency	20623750
Respiratory Tract Diseases
Respiratory Tract Diseases	Asthma	11994713, 18988661, 16870661
Skin and Connective Tissue Diseases
Skin and Connective Tissue Diseases	Dermatitis	25724174

References

PMID: 23527552

Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

Galazis Nicolas, Pang Yik-Lam, Galazi Myria, Haoula Zeina, Layfield Robert, Atiomo William

Nottingham Medical School, University of Nottingham, Queen's Medical Centre Campus Nottingham University Hospital, Nottingham, UK. ngalazis@gmail.com

Gynecol Endocrinol. 2013 Jul;29(7):638-44. doi: 10.3109/09513590.2013.777416.

Statistics

About BIC

Feedback

Links

Contact Us

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412