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Gene Symbol |
GSTT1 |
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Aliases |
- |
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Entrez Gene ID |
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Gene Name |
Glutathione S-transferase theta 1 |
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Chromosomal Location |
22q11.23 |
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HGNC ID |
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Summary |
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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e!Ensembl
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| Protein Information |
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Protein Name |
Glutathione S-transferase theta-1, GST class-theta-1, glutathione transferase T1-1 |
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Function |
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Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000364210 |
Q15109 |
Q15109 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Raynaud Disease |
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| Hypertensive disease |
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| Raynaud Phenomenon |
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| Digestive System Diseases |
| Liver Diseases |
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| Hepatitis |
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| Non-alcoholic Fatty Liver Disease |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Multiple Myeloma |
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| Carcinoma |
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| Glioblastoma |
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| Renal Cancer |
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| Glioblastoma Multiforme |
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| Lung Cancer |
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| Skin Cancer |
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| Prostate cancer |
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| Esophagus Neoplasm |
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| Anaplastic Carcinoma |
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| Psychiatric/Brain disorders |
| Mental Depression |
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| Schizophrenia |
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| Bipolar Disorder |
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| Reproductive disorders |
| Asthenozoospermia |
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| Respiratory Tract Diseases |
| Pulmonary Fibrosis |
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| Pulmonary asbestosis |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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CYP1A1 and GSTM1 |
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Related
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180 women with confirmed PCO and in 72 healthy fertile women |
In conclusion, the presence of hyperinducible CYP1A1 (T6235C) mutant genotype and its mutants in combination with GSTM1 and GSTT1 null genotypes might cause an imbalance between phase I and phase II enzymes, and therefore may represent a risk factor for PCO. |
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CYP1A1, GSTM1 |
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CYP1A1 (T6235C), GSTM1[-] and GSTT1[-] |
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Related
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254 South Indian women (180 PCO, 72 controls) |
The study concludes that the presence of hyperinducible CYP1A1 (T6235C) mutant genotype and its mutants in combination with GSTM1 and GSTT1 null genotypes might cause an imbalance between phase I and phase II enzymes, and therefore may represent a risk factor for PCO |
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