GZMB: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

GZMB

Aliases

C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT

Entrez Gene ID

3002

Gene Name

Granzyme B

Chromosomal Location

14q12

HGNC ID

HGNC:4709

Summary

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

RefSeq DNA

NG_028340.1

RefSeq mRNA

NM_004131.6, NR_144343.2, NM_001346011.2

e!Ensembl

Gene	ENSG00000100453
Transcript	ENST00000415355, ENST00000216341, ENST00000532263, ENST00000554242, ENST00000530830, ENST00000526004, ENST00000382540, ENST00000382542, ENST00000616551
Protein	ENSP00000387385, ENSP00000216341, ENSP00000432074, ENSP00000450535, ENSP00000435084, ENSP00000434213, ENSP00000371980, ENSP00000371982, ENSP00000479643

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006915	Biological process	Apoptotic process	TAS	12524539
GO:0008626	Biological process	Granzyme-mediated apoptotic signaling pathway	IBA	21873635
GO:0042267	Biological process	Natural killer cell mediated cytotoxicity	IMP	21795594
GO:0001772	Cellular component	Immunological synapse	TAS	12524539
GO:0005634	Cellular component	Nucleus	TAS	11909973
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0004252	Molecular function	Serine-type endopeptidase activity	IDA	11331782
GO:0004252	Molecular function	Serine-type endopeptidase activity	TAS	12524539
GO:0005515	Molecular function	Protein binding	IPI	11911826, 16267761
GO:0008236	Molecular function	Serine-type peptidase activity	TAS	2402757

Protein Information

Protein Name

Granzyme B, T-cell serine protease 1-3E, cathepsin G-like 1, cytotoxic T-lymphocyte proteinase 2, cytotoxic serine protease B, fragmentin 2, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), human lymphocyte protein

Function

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Refseq Proteins

NP_004122.2, , NP_001332940.1

UniProt

P10144

PDB

1FQ3, 1IAU

Pfam

Pfam Accession	Pfam ID
PF00089	Trypsin