HDAC3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

HDAC3

Aliases

HD3, KDAC3, RPD3, RPD3-2

Entrez Gene ID

8841

Gene Name

Histone deacetylase 3

Chromosomal Location

5q31.3

HGNC ID

HGNC:4854

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_029678.2

RefSeq mRNA

NM_003883.4, NR_149164.1, NR_149165.1, NR_149166.1, NR_149167.2, NR_149168.1, NR_149169.1, NM_001355039.2, NM_001355040.1, NM_001355041.1

e!Ensembl

Gene	ENSG00000171720
Transcript	ENST00000305264, ENST00000523088, ENST00000519474
Protein	ENSP00000302967, ENSP00000429099, ENSP00000430782

Gene Ontology (GO)

Show/Hide all(43 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IDA	16569215, 18417529, 18854353
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IMP	12628926
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IDA	25190803
GO:0006325	Biological process	Chromatin organization	TAS	12711221
GO:0006476	Biological process	Protein deacetylation	IDA	17172643, 21030595
GO:0010832	Biological process	Negative regulation of myotube differentiation	IMP	10983972
GO:0031647	Biological process	Regulation of protein stability	IDA	25190803
GO:0032008	Biological process	Positive regulation of TOR signaling	IMP	25190803
GO:0042307	Biological process	Positive regulation of protein import into nucleus	IDA	25190803
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	10777477
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IMP	16924111
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	25190803
GO:0046329	Biological process	Negative regulation of JNK cascade	IMP	11931768
GO:0051225	Biological process	Spindle assembly	IMP	18326024
GO:0070932	Biological process	Histone H3 deacetylation	IBA	21873635
GO:0070933	Biological process	Histone H4 deacetylation	IBA	21873635
GO:0071498	Biological process	Cellular response to fluid shear stress	IDA	25190803
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	28614293
GO:0000118	Cellular component	Histone deacetylase complex	IBA	21873635
GO:0000118	Cellular component	Histone deacetylase complex	IDA	18326024
GO:0000118	Cellular component	Histone deacetylase complex	TAS	12711221
GO:0005634	Cellular component	Nucleus	IDA	18326024, 18347167, 21030595
GO:0005634	Cellular component	Nucleus	TAS	12711221
GO:0005737	Cellular component	Cytoplasm	IDA	25190803
GO:0005737	Cellular component	Cytoplasm	TAS	12711221
GO:0005829	Cellular component	Cytosol	IDA	21030595
GO:0017053	Cellular component	Transcriptional repressor complex	IDA	11804585, 12628926, 16569215, 18417529
GO:0072686	Cellular component	Mitotic spindle	IDA	18326024
GO:0003682	Molecular function	Chromatin binding	IDA	16569215, 18417529
GO:0003714	Molecular function	Transcription corepressor activity	IDA	16569215, 18417529
GO:0003714	Molecular function	Transcription corepressor activity	IMP	12628926
GO:0004407	Molecular function	Histone deacetylase activity	IBA	21873635
GO:0004407	Molecular function	Histone deacetylase activity	IMP	16924111, 18326024
GO:0004407	Molecular function	Histone deacetylase activity	TAS	12711221
GO:0005515	Molecular function	Protein binding	IPI	10898795, 11006275, 11013263, 11259576, 11641274, 11861901, 15016912, 15194749, 15805470, 16432238, 16461912, 16847267, 16917504, 16924111, 16980585, 17053781, 17075044, 17172643, 17895379, 17956988, 18279852, 18854353, 19409814, 20385135, 21030595, 21258344, 21624135, 21914818, 221
GO:0008134	Molecular function	Transcription factor binding	IPI	16569215
GO:0008134	Molecular function	Transcription factor binding	TAS	12711221
GO:0019899	Molecular function	Enzyme binding	IPI	11641274
GO:0030332	Molecular function	Cyclin binding	IPI	18417529
GO:0033558	Molecular function	Protein deacetylase activity	IDA	17172643
GO:0042826	Molecular function	Histone deacetylase binding	IPI	10869435, 12590135, 23867755
GO:0051059	Molecular function	NF-kappaB binding	IPI	17785205

Protein Information

Protein Name

Histone deacetylase 3, SMAP45

Function

Refseq Proteins

NP_003874.2, , NP_001341968.1, NP_001341969.1, NP_001341970.1

UniProt

O15379

PDB

4A69

Pfam

Pfam Accession	Pfam ID
PF00850	Hist_deacetyl

HDAC3

Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.