HMOX1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

HMOX1

Aliases

HMOX1D, HO-1, HSP32, bK286B10

Entrez Gene ID

3162

Gene Name

Heme oxygenase 1

Chromosomal Location

22q12.3

HGNC ID

HGNC:5013

Summary

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_023030.1

RefSeq mRNA

NM_002133.3

e!Ensembl

Gene	ENSG00000100292
Transcript	ENST00000412893, ENST00000216117
Protein	ENSP00000413316, ENSP00000216117

Gene Ontology (GO)

Show/Hide all(45 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001525	Biological process	Angiogenesis	TAS	12239590
GO:0001935	Biological process	Endothelial cell proliferation	TAS	12239590
GO:0002246	Biological process	Wound healing involved in inflammatory response	IMP	9884342
GO:0002686	Biological process	Negative regulation of leukocyte migration	TAS	14525760
GO:0006788	Biological process	Heme oxidation	IBA	21873635
GO:0006788	Biological process	Heme oxidation	IDA	17915953
GO:0006879	Biological process	Cellular iron ion homeostasis	IMP	22989377
GO:0006979	Biological process	Response to oxidative stress	IBA	21873635
GO:0006979	Biological process	Response to oxidative stress	IMP	9884342
GO:0007588	Biological process	Excretion	IC	17915953
GO:0014806	Biological process	Smooth muscle hyperplasia	TAS	18289072
GO:0034101	Biological process	Erythrocyte homeostasis	IMP	9884342
GO:0034383	Biological process	Low-density lipoprotein particle clearance	TAS	9884342
GO:0034605	Biological process	Cellular response to heat	IMP	21597468
GO:0035094	Biological process	Response to nicotine	IDA	18205746
GO:0035556	Biological process	Intracellular signal transduction	TAS	17652371
GO:0042167	Biological process	Heme catabolic process	IBA	21873635
GO:0042167	Biological process	Heme catabolic process	IDA	17915953
GO:0043123	Biological process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP	12761501
GO:0045080	Biological process	Positive regulation of chemokine biosynthetic process	TAS	17652371
GO:0045765	Biological process	Regulation of angiogenesis	TAS	17652371
GO:0045766	Biological process	Positive regulation of angiogenesis	IDA	21788589
GO:0048661	Biological process	Positive regulation of smooth muscle cell proliferation	IDA	17600318
GO:0048662	Biological process	Negative regulation of smooth muscle cell proliferation	IDA	17600318
GO:0051260	Biological process	Protein homooligomerization	IDA	19556236
GO:0055072	Biological process	Iron ion homeostasis	IBA	21873635
GO:0055072	Biological process	Iron ion homeostasis	IDA	17915953
GO:0055072	Biological process	Iron ion homeostasis	IMP	9884342
GO:0071456	Biological process	Cellular response to hypoxia	IEP	12511571
GO:0090050	Biological process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	24844779
GO:0097755	Biological process	Positive regulation of blood vessel diameter	IC	17915953
GO:1902042	Biological process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP	18202225
GO:1903589	Biological process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	24844779
GO:0005615	Cellular component	Extracellular space	TAS	18307065
GO:0005783	Cellular component	Endoplasmic reticulum	IDA	19556236, 22503972
GO:0016020	Cellular component	Membrane	IBA	21873635
GO:0048471	Cellular component	Perinuclear region of cytoplasm	IDA	22503972
GO:0004392	Molecular function	Heme oxygenase (decyclizing) activity	IBA	21873635
GO:0004392	Molecular function	Heme oxygenase (decyclizing) activity	IDA	17915953
GO:0004392	Molecular function	Heme oxygenase (decyclizing) activity	IMP	19556236
GO:0005515	Molecular function	Protein binding	IPI	21044950, 21597468
GO:0019899	Molecular function	Enzyme binding	ISS	15516695
GO:0020037	Molecular function	Heme binding	IBA	21873635
GO:0020037	Molecular function	Heme binding	IDA	17915953
GO:0042803	Molecular function	Protein homodimerization activity	IDA	19556236

Protein Information

Protein Name

Heme oxygenase 1, heat shock protein, 32-kD, heme oxygenase (decycling) 1

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis

Refseq Proteins

NP_002124.1

UniProt

P09601

PDB

1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ, 6EHA

Pfam

Pfam Accession	Pfam ID
PF01126	Heme_oxygenase