HSP90B1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

HSP90B1

Aliases

ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1

Entrez Gene ID

7184

Gene Name

Heat shock protein 90 beta family member 1

Chromosomal Location

12q23.3

HGNC ID

HGNC:12028

Summary

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

e!Ensembl

Gene	ENSG00000166598
Transcript	ENST00000549334, ENST00000299767, ENST00000540297, ENST00000550595, ENST00000614327, ENST00000640977
Protein	ENSP00000446748, ENSP00000299767, ENSP00000446266, ENSP00000450215, ENSP00000477660, ENSP00000492386

Gene Ontology (GO)

Show/Hide all(35 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001666	Biological process	Response to hypoxia	IDA	15620698
GO:0006457	Biological process	Protein folding	IBA	21873635
GO:0015031	Biological process	Protein transport	NAS	15845869
GO:0030433	Biological process	Ubiquitin-dependent ERAD pathway	IBA	21873635
GO:0030433	Biological process	Ubiquitin-dependent ERAD pathway	IMP	18264092
GO:0030970	Biological process	Retrograde protein transport, ER to cytosol	IMP	25660456
GO:0031247	Biological process	Actin rod assembly	IDA	19000834
GO:0034975	Biological process	Protein folding in endoplasmic reticulum	TAS	22013210
GO:0034976	Biological process	Response to endoplasmic reticulum stress	TAS	22934019
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	10497210, 15192333
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	16130169
GO:0043666	Biological process	Regulation of phosphoprotein phosphatase activity	IDA	19000834
GO:0051208	Biological process	Sequestering of calcium ion	NAS	15192333
GO:0071318	Biological process	Cellular response to ATP	IDA	19000834
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0005783	Cellular component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Cellular component	Endoplasmic reticulum	IDA	17344063
GO:0005783	Cellular component	Endoplasmic reticulum	TAS	16130169
GO:0005788	Cellular component	Endoplasmic reticulum lumen	IDA	10497210
GO:0005789	Cellular component	Endoplasmic reticulum membrane	IDA	10497210
GO:0005829	Cellular component	Cytosol	IDA	9596688
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0030496	Cellular component	Midbody	IDA	15166316
GO:0032991	Cellular component	Protein-containing complex	IDA	23349634
GO:0048471	Cellular component	Perinuclear region of cytoplasm	IBA	21873635
GO:0048471	Cellular component	Perinuclear region of cytoplasm	IDA	10497210
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	23658023
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708, 20458337
GO:0003723	Molecular function	RNA binding	IDA	11958450
GO:0005509	Molecular function	Calcium ion binding	TAS	10497210
GO:0005515	Molecular function	Protein binding	IPI	9596688, 11907036, 11958450, 15845869, 18264092, 23349634, 23995768, 26496610, 30021884
GO:0019903	Molecular function	Protein phosphatase binding	IDA	19000834
GO:0050750	Molecular function	Low-density lipoprotein particle receptor binding	IDA	15082773
GO:0051082	Molecular function	Unfolded protein binding	IBA	21873635

Protein Information

Protein Name

Endoplasmin, 94 kDa glucose-regulated protein, endothelial cell (HBMEC) glycoprotein, epididymis luminal protein 35, epididymis secretory sperm binding protein Li 125m, heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, heat shock protein 90kDa beta family member 1, stress-inducible tumor rejection antigen gp96, tumor rejection antigen (gp96) 1, tumor rejection antigen 1

Function

Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity).

UniProt

P14625

PDB

4NH9

Pfam

Pfam Accession	Pfam ID
PF02518	HATPase_c
PF00183	HSP90