HSPA5: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

HSPA5

Aliases

BIP, GRP78, HEL-S-89n, MIF2

Entrez Gene ID

3309

Gene Name

Heat shock protein family A (Hsp70) member 5

Chromosomal Location

9q33.3

HGNC ID

HGNC:5238

Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

RefSeq DNA

NG_027761.1

RefSeq mRNA

NM_005347.5

e!Ensembl

Gene	ENSG00000044574
Transcript	ENST00000324460
Protein	ENSP00000324173

Gene Ontology (GO)

Show/Hide all(63 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006986	Biological process	Response to unfolded protein	IBA	21873635
GO:0021762	Biological process	Substantia nigra development	HEP	22926577
GO:0030335	Biological process	Positive regulation of cell migration	IMP	23990668
GO:0030433	Biological process	Ubiquitin-dependent ERAD pathway	IBA	21873635
GO:0030433	Biological process	Ubiquitin-dependent ERAD pathway	TAS	19816510
GO:0030968	Biological process	Endoplasmic reticulum unfolded protein response	IBA	21873635
GO:0030968	Biological process	Endoplasmic reticulum unfolded protein response	TAS	19816510
GO:0031204	Biological process	Posttranslational protein targeting to membrane, translocation	IMP	29719251
GO:0034605	Biological process	Cellular response to heat	IBA	21873635
GO:0034620	Biological process	Cellular response to unfolded protein	IBA	21873635
GO:0034975	Biological process	Protein folding in endoplasmic reticulum	TAS	22013210
GO:0035437	Biological process	Maintenance of protein localization in endoplasmic reticulum	IMP	23990668
GO:0042026	Biological process	Protein refolding	IBA	21873635
GO:0042149	Biological process	Cellular response to glucose starvation	IDA	10085239
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	10760948, 12665508
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	16130169
GO:0051085	Biological process	Chaperone cofactor-dependent protein refolding	IBA	21873635
GO:0060904	Biological process	Regulation of protein folding in endoplasmic reticulum	TAS	19816510
GO:0090074	Biological process	Negative regulation of protein homodimerization activity	TAS	14685163
GO:1903891	Biological process	Regulation of ATF6-mediated unfolded protein response	TAS	22934019
GO:1903894	Biological process	Regulation of IRE1-mediated unfolded protein response	TAS	22934019
GO:1903897	Biological process	Regulation of PERK-mediated unfolded protein response	TAS	22934019
GO:1990440	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	TAS	14685163
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IMP	11943137
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	22689054
GO:0005739	Cellular component	Mitochondrion	IDA	22689054
GO:0005783	Cellular component	Endoplasmic reticulum	IDA	16223484
GO:0005783	Cellular component	Endoplasmic reticulum	IMP	11943137
GO:0005783	Cellular component	Endoplasmic reticulum	TAS	16130169
GO:0005788	Cellular component	Endoplasmic reticulum lumen	IBA	21873635
GO:0005793	Cellular component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636
GO:0005829	Cellular component	Cytosol	IDA	22689054
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0008180	Cellular component	COP9 signalosome	IDA	18850735
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016020	Cellular component	Membrane	IBA	21873635
GO:0030176	Cellular component	Integral component of endoplasmic reticulum membrane	IDA	11181571
GO:0030496	Cellular component	Midbody	IDA	15166316
GO:0032991	Cellular component	Protein-containing complex	IDA	23349634
GO:0034663	Cellular component	Endoplasmic reticulum chaperone complex	IBA	21873635
GO:0034663	Cellular component	Endoplasmic reticulum chaperone complex	IDA	18400946
GO:0043231	Cellular component	Intracellular membrane-bounded organelle	IDA	22689054
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 19199708, 20458337
GO:0005509	Molecular function	Calcium ion binding	TAS	16130169
GO:0005515	Molecular function	Protein binding	IPI	11907036, 18064632, 18264092, 18502753, 18923428, 18923430, 19632185, 20335166, 20477988, 21445305, 22613557, 22689054, 22735594, 22796945, 23220234, 23349634, 23769672, 23990668, 24189400, 25601083, 26496610, 26551274, 27238082, 30021884
GO:0005524	Molecular function	ATP binding	IBA	21873635
GO:0016887	Molecular function	ATPase activity	IBA	21873635
GO:0016887	Molecular function	ATPase activity	IDA	20335166, 23975754
GO:0019899	Molecular function	Enzyme binding	IPI	23921388
GO:0019904	Molecular function	Protein domain specific binding	IPI	12411443
GO:0031072	Molecular function	Heat shock protein binding	IBA	21873635
GO:0031625	Molecular function	Ubiquitin protein ligase binding	IPI	8666824
GO:0042623	Molecular function	ATPase activity, coupled	IBA	21873635
GO:0044183	Molecular function	Protein binding involved in protein folding	IBA	21873635
GO:0045296	Molecular function	Cadherin binding	HDA	25468996
GO:0051082	Molecular function	Unfolded protein binding	IBA	21873635
GO:0051082	Molecular function	Unfolded protein binding	TAS	14685163, 16130169, 22013210
GO:0051087	Molecular function	Chaperone binding	TAS	19816510
GO:0051787	Molecular function	Misfolded protein binding	IBA	21873635
GO:0051787	Molecular function	Misfolded protein binding	IDA	18400946

Protein Information

Protein Name

Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, HSP70 family protein 5, binding-immunoglobulin protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, glucose-regulated protein, 78kDa, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), heat shock protein 70 family protein 5, heat shock protein family A member 5, immunoglobulin heavy chain-binding protein

Function

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.

Refseq Proteins

NP_005338.1

UniProt

P11021

PDB

3IUC, 3LDL, 3LDN, 3LDO, 3LDP, 5E84, 5E85, 5E86, 5EVZ, 5EX5, 5EXW, 5EY4, 5F0X, 5F1X, 5F2R, 6ASY, 6CZ1

Pfam

Pfam Accession	Pfam ID
PF00012	HSP70