HSPA6: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

HSPA6

Aliases

HSP70B`

Entrez Gene ID

3310

Gene Name

Heat shock protein family A (Hsp70) member 6

Chromosomal Location

1q23.3

HGNC ID

HGNC:5239

e!Ensembl

Gene	ENSG00000173110
Transcript	ENST00000309758
Protein	ENSP00000310219

Gene Ontology (GO)

Show/Hide all(32 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006986	Biological process	Response to unfolded protein	IBA	21873635
GO:0034605	Biological process	Cellular response to heat	IBA	21873635
GO:0034605	Biological process	Cellular response to heat	IDA	24061851
GO:0034605	Biological process	Cellular response to heat	IMP	21597468
GO:0034620	Biological process	Cellular response to unfolded protein	IBA	21873635
GO:0042026	Biological process	Protein refolding	IBA	21873635
GO:0042026	Biological process	Protein refolding	IDA	21231916
GO:0051085	Biological process	Chaperone cofactor-dependent protein refolding	IBA	21873635
GO:0070370	Biological process	Cellular heat acclimation	IMP	21231916
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	24061851
GO:0005814	Cellular component	Centriole	IDA	24061851
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0005829	Cellular component	Cytosol	IDA	21231916
GO:0008180	Cellular component	COP9 signalosome	IBA	21873635
GO:0008180	Cellular component	COP9 signalosome	IDA	18850735
GO:0032991	Cellular component	Protein-containing complex	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708
GO:0072562	Cellular component	Blood microparticle	HDA	22516433
GO:0005515	Molecular function	Protein binding	IPI	21044950
GO:0005524	Molecular function	ATP binding	IBA	21873635
GO:0016887	Molecular function	ATPase activity	IBA	21873635
GO:0019899	Molecular function	Enzyme binding	IPI	23921388
GO:0031072	Molecular function	Heat shock protein binding	IBA	21873635
GO:0031072	Molecular function	Heat shock protein binding	IPI	21231916
GO:0042623	Molecular function	ATPase activity, coupled	IBA	21873635
GO:0042623	Molecular function	ATPase activity, coupled	IDA	21231916
GO:0044183	Molecular function	Protein binding involved in protein folding	IBA	21873635
GO:0051082	Molecular function	Unfolded protein binding	IBA	21873635
GO:0051082	Molecular function	Unfolded protein binding	IDA	21231916
GO:0051787	Molecular function	Misfolded protein binding	IBA	21873635

Protein Information

Protein Name

Heat shock 70 kDa protein 6, epididymis secretory sperm binding protein, heat shock 70 kDa protein B`, heat shock 70kD protein 6 (HSP70B`), heat shock 70kDa protein 6 (HSP70B`)

Function

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).

UniProt

P17066

PDB

3FE1

Pfam

Pfam Accession	Pfam ID
PF00012	HSP70

HSPA6

Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.