IAPP: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IAPP

Aliases

DAP, IAP

Entrez Gene ID

3375

Gene Name

Islet amyloid polypeptide

Chromosomal Location

12p12.1

HGNC ID

HGNC:5329

Summary

This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

e!Ensembl

Gene	ENSG00000121351
Transcript	ENST00000539393, ENST00000240652, ENST00000542023, ENST00000537593, ENST00000535428
Protein	ENSP00000437357, ENSP00000240652, ENSP00000445711, ENSP00000445980, ENSP00000437559

Gene Ontology (GO)

Show/Hide all(17 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006915	Biological process	Apoptotic process	TAS	8152488
GO:0007165	Biological process	Signal transduction	TAS	10342886
GO:0007204	Biological process	Positive regulation of cytosolic calcium ion concentration	NAS	22500019
GO:0007267	Biological process	Cell-cell signaling	TAS	2608057
GO:0010739	Biological process	Positive regulation of protein kinase A signaling	NAS	22500019
GO:0010823	Biological process	Negative regulation of mitochondrion organization	TAS	22500019
GO:0032463	Biological process	Negative regulation of protein homooligomerization	TAS	22500019
GO:0043065	Biological process	Positive regulation of apoptotic process	TAS	22500019
GO:0043410	Biological process	Positive regulation of MAPK cascade	NAS	22500019
GO:0051260	Biological process	Protein homooligomerization	TAS	22500019
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	NAS	22500019
GO:1905907	Biological process	Negative regulation of amyloid fibril formation	TAS	22500019
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0001540	Molecular function	Amyloid-beta binding	TAS	22500019
GO:0005102	Molecular function	Signaling receptor binding	TAS	2608057, 10342886
GO:0005515	Molecular function	Protein binding	IPI	17051221
GO:0042802	Molecular function	Identical protein binding	IPI	17640888, 18408164, 21130765, 24042052, 24561193

Protein Information

Protein Name

Islet amyloid polypeptide, Islet amyloid polypeptide (diabetes-associated peptide; amylin), amylin, diabetes-associated peptide, insulinoma amyloid peptide

Function

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism

UniProt

P10997

PDB

1KUW, 2G48, 2KB8, 2L86, 3DG1, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 5K5G, 5KNZ, 5KO0, 5MGQ

Pfam

Pfam Accession	Pfam ID
PF00214	Calc_CGRP_IAPP