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Gene Symbol |
ICAM1 |
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Aliases |
BB2, CD54, P3.58 |
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Entrez Gene ID |
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Gene Name |
Intercellular adhesion molecule 1 |
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Chromosomal Location |
19p13.2 |
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HGNC ID |
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Summary |
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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Protein Information |
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Protein Name |
Intercellular adhesion molecule 1, ICAM-1, cell surface glycoprotein P3.58, epididymis secretory sperm binding protein, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor |
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Function |
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UniProt |
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PDB |
1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1IJ4, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX, 5MZA, 6EIT |
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Pfam |
Pfam Accession |
Pfam ID |
PF03921 |
ICAM_N |
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Interactions |
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STRING |
MINT |
IntAct |
ENSP00000370842 |
O95760 |
O95760 |
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View interactions
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Associated Diseases
Disease group | Disease Name | References |
Blood Disorders |
Leukostasis |
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Cardiovascular Diseases |
Atherosclerosis |
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Myocardial Infarction |
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Hypertensive disease |
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Myocardial Ischemia |
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Digestive System Diseases |
Inflammatory Bowel Diseases |
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Colitis |
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Cholestasis |
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Ear Or Mastoid Diseases |
Meniere Disease |
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Endocrine System Diseases |
Diabetes Mellitus |
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PCOS |
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Eye Diseases |
Retinal Diseases |
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Diabetic Retinopathy |
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Immune System Diseases |
Urticaria |
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Behcet Syndrome |
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Neoplasms |
Colonic Neoplasms |
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Multiple Sclerosis |
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Mouth Neoplasms |
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Prostate cancer |
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Nervous System Diseases |
Cerebral Ischemia |
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Cerebral Artery Infarction |
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Middle Cerebral Artery Syndrome |
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Neuropathy |
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Cerebral Thrombosis |
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Brain Infarction |
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Stroke |
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Nutritional and Metabolic Diseases |
Hypercholesterolemia |
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Obesity |
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Psychiatric/Brain disorders |
Schizophrenia |
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Obstructive Sleep Apnea |
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Renal Disorder |
Nephrosis |
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Uremia |
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Reproductive disorders |
Preeclampsia |
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Respiratory Tract Diseases |
Bronchiectasis |
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Pleuritis |
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Bronchial hyperreactivity |
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Asthma |
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References |
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Ojeda-Ojeda Miriam, Martinez-Garcia M Angeles, Alpanes Macarena, Luque-Ramirez Manuel, Escobar-Morreale Hector F |
Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain. Electronic address: ojedaojedamiriam@gmail.com.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain. Electronic address: hectorfrancisco.escobar@salud.madrid.org. |
J Reprod Immunol. 2016 Feb;113:9-15. doi: 10.1016/j.jri.2015.09.072. Epub 2015 |
Abstract
Toll-like receptors (TLRs) are activated by inflammatory stimuli and influence endothelial functions, contributing to the pathogenesis of atherosclerosis. We investigate the influence of polymorphisms in the genes encoding toll-like receptor 2 (TLR2) and 4 (TLR4) and endothelial adhesion molecules on polycystic ovary syndrome (PCOS) and its interaction with obesity. Ten single nucleotide polymorphisms were genotyped in 305 women with PCOS and 166 non-hyperandrogenic control women. In obese women, TLR2 S450S and ICAM1 K469E polymorphisms differently influenced metabolic variables and PCOS, respectively. Irrespective of PCOS, variant alleles of TLR2 S450S increased triglycerides, fasting insulin levels, and insulin resistance in obese women. TLR2 S450S interacted with obesity and PCOS on androstenedione levels, mutant alleles were associated with increased androstenedione concentrations in all women, with the exception of obese patients with PCOS (P=0.034). Regarding ICAM1 K469E, homozygosis for K469 alleles was more frequent in PCOS, but only in obese women (P=0.014). K469 alleles were also related to increased body mass index (P=0.017) and diastolic blood pressure (P=0.034). Moreover, ICAM1 K469E interacted with obesity and PCOS on serum triglyceride levels (P=0.019) and with PCOS on serum sex hormone-binding globulin concentrations (P=0.006). In conclusion, TLR2 S450S and ICAM1 K469E polymorphisms may be associated with PCOS and metabolic comorbidities in obese women. |
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