ICAM1

Gene Information
 
Gene Symbol
ICAM1
 
Aliases
BB2, CD54, P3.58
 
Entrez Gene ID
 
Gene Name
Intercellular adhesion molecule 1
 
Chromosomal Location
19p13.2
 
HGNC ID
 
Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001910 Biological process Regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0002291 Biological process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
GO:0002693 Biological process Positive regulation of cellular extravasation IMP 12902516
GO:0007155 Biological process Cell adhesion IBA 21873635
GO:0007155 Biological process Cell adhesion IDA 16809613
Protein Information
 
Protein Name
Intercellular adhesion molecule 1, ICAM-1, cell surface glycoprotein P3.58, epididymis secretory sperm binding protein, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor
 
Function
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF03921 ICAM_N
Pathways
 
KEGG
 
Reactome
 

NF-kappa B signaling pathway
Cell adhesion molecules (CAMs)
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Leukocyte transendothelial migration
AGE-RAGE signaling pathway in diabetic complications
African trypanosomiasis
Malaria
Staphylococcus aureus infection
Influenza A
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditis
Fluid shear stress and atherosclerosis

 

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling

Interactions
 
STRING MINT IntAct
ENSP00000370842 O95760 O95760
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Leukostasis
Cardiovascular Diseases
Atherosclerosis
Myocardial Infarction
Hypertensive disease
Myocardial Ischemia
References
 

Association of TLR2 S450S and ICAM1 K469E polymorphisms with polycystic ovary syndrome (PCOS) and obesity.

Ojeda-Ojeda Miriam, Martinez-Garcia M Angeles, Alpanes Macarena, Luque-Ramirez Manuel, Escobar-Morreale Hector F
Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain. Electronic address: ojedaojedamiriam@gmail.com.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain.| Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS) E-28034 Madrid, Spain & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Spain. Electronic address: hectorfrancisco.escobar@salud.madrid.org.
J Reprod Immunol. 2016 Feb;113:9-15. doi: 10.1016/j.jri.2015.09.072. Epub 2015

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