IGF1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IGF1

Aliases

IGF, IGF-I, IGFI, MGF

Entrez Gene ID

3479

Gene Name

Insulin like growth factor 1

Chromosomal Location

12q23.2

HGNC ID

HGNC:5464

Summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

RefSeq DNA

NG_011713.1

RefSeq mRNA

NM_001111283.3, NM_000618.5, NM_001111284.2, NM_001111285.3

e!Ensembl

Gene	ENSG00000017427
Transcript	ENST00000337514, ENST00000392904, ENST00000644491, ENST00000424202, ENST00000392905, ENST00000307046
Protein	ENSP00000337612, ENSP00000376637, ENSP00000494228, ENSP00000416811, ENSP00000376638, ENSP00000302665

Gene Ontology (GO)

Show/Hide all(83 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000187	Biological process	Activation of MAPK activity	IMP	22351760
GO:0001501	Biological process	Skeletal system development	TAS	10448861
GO:0001775	Biological process	Cell activation	IDA	22797923
GO:0007165	Biological process	Signal transduction	TAS	10448861
GO:0007265	Biological process	Ras protein signal transduction	TAS	10848592
GO:0007517	Biological process	Muscle organ development	TAS	10448861
GO:0008283	Biological process	Cell proliferation	IMP	1847964, 9714146
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	7688386, 9722506, 12746903
GO:0008284	Biological process	Positive regulation of cell proliferation	IMP	19578119
GO:0009408	Biological process	Response to heat	IDA	11404306
GO:0009441	Biological process	Glycolate metabolic process	TAS	10448861
GO:0010468	Biological process	Regulation of gene expression	IMP	21543511
GO:0010560	Biological process	Positive regulation of glycoprotein biosynthetic process	IMP	9564845
GO:0010613	Biological process	Positive regulation of cardiac muscle hypertrophy	IDA	19654000
GO:0010613	Biological process	Positive regulation of cardiac muscle hypertrophy	IMP	19933931
GO:0010628	Biological process	Positive regulation of gene expression	IGI	22635104
GO:0010629	Biological process	Negative regulation of gene expression	IDA	29167509
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IMP	24508636
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IDA	7688386
GO:0014834	Biological process	Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IDA	17531227
GO:0014896	Biological process	Muscle hypertrophy	IMP	10191278
GO:0014904	Biological process	Myotube cell development	IDA	17531227
GO:0014911	Biological process	Positive regulation of smooth muscle cell migration	IDA	10766744
GO:0030166	Biological process	Proteoglycan biosynthetic process	IDA	12746903
GO:0030166	Biological process	Proteoglycan biosynthetic process	IMP	9564845
GO:0030335	Biological process	Positive regulation of cell migration	IMP	24508636
GO:0032148	Biological process	Activation of protein kinase B activity	IMP	22351760
GO:0032691	Biological process	Negative regulation of interleukin-1 beta production	IGI	27277332
GO:0032720	Biological process	Negative regulation of tumor necrosis factor production	IGI	27277332
GO:0034392	Biological process	Negative regulation of smooth muscle cell apoptotic process	IDA	16942485
GO:0035630	Biological process	Bone mineralization involved in bone maturation	IDA	16433617
GO:0040014	Biological process	Regulation of multicellular organism growth	IEP	8421089
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IDA	15694994
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	9722506
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	11949853
GO:0043388	Biological process	Positive regulation of DNA binding	IDA	19654000
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	19654000
GO:0043491	Biological process	Protein kinase B signaling	IMP	24508636
GO:0043568	Biological process	Positive regulation of insulin-like growth factor receptor signaling pathway	IDA	7688386, 10766744
GO:0045445	Biological process	Myoblast differentiation	IDA	17531227
GO:0045669	Biological process	Positive regulation of osteoblast differentiation	IDA	16433617
GO:0045725	Biological process	Positive regulation of glycogen biosynthetic process	IDA	21076856
GO:0045821	Biological process	Positive regulation of glycolytic process	IDA	7688386
GO:0045840	Biological process	Positive regulation of mitotic nuclear division	IDA	7188854, 10644978
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	9722506, 19654000
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	15059951
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	16433617
GO:0046326	Biological process	Positive regulation of glucose import	IDA	21076856
GO:0046579	Biological process	Positive regulation of Ras protein signal transduction	IDA	9722506
GO:0048009	Biological process	Insulin-like growth factor receptor signaling pathway	IMP	19578119, 22351760
GO:0048015	Biological process	Phosphatidylinositol-mediated signaling	IDA	7692086
GO:0048146	Biological process	Positive regulation of fibroblast proliferation	IDA	7188854
GO:0048661	Biological process	Positive regulation of smooth muscle cell proliferation	IDA	10766744, 16942485
GO:0050679	Biological process	Positive regulation of epithelial cell proliferation	IDA	7188854
GO:0050714	Biological process	Positive regulation of protein secretion	IMP	9564845
GO:0050731	Biological process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	7782332, 22635104
GO:0050821	Biological process	Protein stabilization	IMP	9564845
GO:0051450	Biological process	Myoblast proliferation	IDA	17531227
GO:0060283	Biological process	Negative regulation of oocyte development	IMP	21543511
GO:0061051	Biological process	Positive regulation of cell growth involved in cardiac muscle cell development	IDA	24117217
GO:0061051	Biological process	Positive regulation of cell growth involved in cardiac muscle cell development	IGI	24117217
GO:0070371	Biological process	ERK1 and ERK2 cascade	IMP	24508636
GO:0070886	Biological process	Positive regulation of calcineurin-NFAT signaling cascade	IDA	19654000
GO:0150079	Biological process	Negative regulation of neuroinflammatory response	IGI	27277332
GO:1902430	Biological process	Negative regulation of amyloid-beta formation	IGI	27277332
GO:1904075	Biological process	Positive regulation of trophectodermal cell proliferation	IMP	24508636
GO:1904646	Biological process	Cellular response to amyloid-beta	IGI	22635104
GO:1904707	Biological process	Positive regulation of vascular smooth muscle cell proliferation	IMP	26166810
GO:1905460	Biological process	Negative regulation of vascular associated smooth muscle cell apoptotic process	IMP	26166810
GO:2000679	Biological process	Positive regulation of transcription regulatory region DNA binding	IDA	15059951
GO:2001237	Biological process	Negative regulation of extrinsic apoptotic signaling pathway	IDA	16942485
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005615	Cellular component	Extracellular space	IDA	7188854, 11404306, 17119061, 25152160
GO:0016942	Cellular component	Insulin-like growth factor binding protein complex	IC	10766744
GO:0035867	Cellular component	Alphav-beta3 integrin-IGF-1-IGF1R complex	IDA	19578119
GO:0042567	Cellular component	Insulin-like growth factor ternary complex	IDA	9497324
GO:0005158	Molecular function	Insulin receptor binding	IPI	8452530
GO:0005159	Molecular function	Insulin-like growth factor receptor binding	IDA	19578119
GO:0005159	Molecular function	Insulin-like growth factor receptor binding	IMP	1847964, 2967174
GO:0005159	Molecular function	Insulin-like growth factor receptor binding	IPI	8452530
GO:0005178	Molecular function	Integrin binding	IDA	19578119, 22351760
GO:0005179	Molecular function	Hormone activity	IDA	7188854
GO:0005515	Molecular function	Protein binding	IPI	8452530, 10766744, 15642270, 16924115, 21645859, 22578544, 26027733

Protein Information

Protein Name

Insulin-like growth factor I, insulin-like growth factor 1 (somatomedin C), insulin-like growth factor IB, mechano growth factor, somatomedin-C

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1

Refseq Proteins

NP_001104753.1, NP_000609.1, NP_001104754.1, NP_001104755.1

UniProt

P05019

PDB

2DSQ, 1WQJ, 2DSP, 2DSR, 1H59, 4XSS, 5U8Q, 1B9G, 1BQT, 1GF1, 1GZR, 1GZY, 1GZZ, 1H02, 1IMX, 1PMX, 1TGR, 2GF1, 3GF1, 3LRI, 6FF3

Pfam

Pfam Accession	Pfam ID
PF00049	Insulin