IGFBP1: Polycystic Ovarian Syndrome Database

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IGFBP1

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

IGFBP1

Aliases

AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1

Entrez Gene ID

3484

Gene Name

Insulin like growth factor binding protein 1

Chromosomal Location

7p12.3

HGNC ID

HGNC:5469

Summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

e!Ensembl

Gene	ENSG00000146678
Transcript	ENST00000275525, ENST00000457280, ENST00000468955
Protein	ENSP00000275525, ENSP00000413511, ENSP00000417069

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007165	Biological process	Signal transduction	TAS	2454104
GO:0043567	Biological process	Regulation of insulin-like growth factor receptor signaling pathway	IBA	21873635
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	TAS	24431302
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005102	Molecular function	Signaling receptor binding	TAS	24431302
GO:0005515	Molecular function	Protein binding	IPI	16924115, 22578544, 26091039
GO:0005520	Molecular function	Insulin-like growth factor binding	TAS	2454104
GO:0031994	Molecular function	Insulin-like growth factor I binding	IBA	21873635
GO:0031994	Molecular function	Insulin-like growth factor I binding	IDA	21550830
GO:0031995	Molecular function	Insulin-like growth factor II binding	IBA	21873635
GO:0031995	Molecular function	Insulin-like growth factor II binding	IDA	21550830

Protein Information

Protein Name

Insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1, alpha-pregnancy-associated endometrial globulin, amniotic fluid binding protein, binding protein-25, binding protein-26, binding protein-28, growth hormone independent-binding protein, placental protein 12

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

UniProt

P08833

PDB

1ZT3, 1ZT5, 2DSQ

Pfam

Pfam Accession	Pfam ID
PF00219	IGFBP
PF00086	Thyroglobulin_1

Pathways
	Reactome
		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

Interactions

STRING	MINT	IntAct
ENSP00000370473	P17936	P17936

View interactions

Associated Diseases

Show/Hide all(7 )

Disease group	Disease Name	References
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Russell-Silver syndrome	10364674
Digestive System Diseases
	Biliary Cirrhosis	18422935
	Liver Fibrosis	26396155
	Liver Cirrhosis	26396155
Endocrine System Diseases
Endocrine System Diseases	PCOS	1283982
Neoplasms
Neoplasms	Colonic Neoplasms	15059925
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	Gluocose Intolerance	10868969
Renal Disorder
	Kidney Failure	7540432
	Kidney Insufficiency	7540432
Reproductive disorders
	Endometriosis	20864642
	Endometrioma	20864642
	Preeclampsia	26717016

References

Show/Hide all(10)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
10895282	SHBG				Related	21 PCO, 18 obese women without menstrual disturbances and 9 Control	obese women with PCO insulin influence ovarian androgen production and decreases the serum SHBG and IGFBP-1 which could contribute in the augmentation of the symptoms of PCO
1283982	IGF-1 and IGF				Related	10 PCOS, 12 hypopituitarism and 10 Control	Women with PCOS have normal serum IGF-1 concentrations but IGFBP-1 levels, regulated by insulin, are low
20634211					Related		Decreased serum level of IGFBP-1 is unlikely to be a mechanism for ovarian hyperandrogenism in PCOS
18569034	Matrix metalloproteinases(MMPs)				Related	42 PCOS and 30 Control	MMPs may be implicated in the pathophysiology of PCOS either by regulating ovarian tissue remodeling or indirectly by facilitating IGF-I bioavailability through proteolysis of IGFBP-1
14764802	Glycodelin			PCOS was diagnosed before pregnancy, and defined by oligomenorrhea (eight or fewer menstrual periods annually before pregnancy) and hyperandrogenism (elevated serum free testosterone concentration or hirsutism)	Related	72 PCOS and 62 Control	During the first trimester, serum glycodelin and IGFBP-1 concentrations are markedly decreased in PCOS, implicating endometrial epithelial and stromal dysfunction during periimplantation and early pregnancy as a possible mechanism for EPL in PCOS
9032568		insulin sensitivity			Related	15 PCOS and 10 Control	Insulin sensitivity contributed to the difference in IGFBP-1 levels found in women with PCOS
7554310	SHBG				Direct	10 PCOS and 10 controls	that there is no diurnal variation in SHBG concentrations and confirms the finding of a marked diurnal variation in the concentration of IGFBP-1
7534449		hyperinsulinemia and hyperandrogenemia			Related	16 PCOS and 20 control	insulin and body mass index are the major determinants of circulating IGFBP1 and that chronic hyperandrogenemia does not appear to further reduce serum IGFBP1 levels in obese or normal-weight women withPCOS
7511134	SHBG and GH				Related	8 PCOS	specific secretion pattern of IGFBP-1 is not directly dependent on body fat mass but is regulated by insulin in both obese and non-obese patients.
7693380	SHBG				Related	6 PCOS

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