IGFBP2: Polycystic Ovarian Syndrome Database

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IGFBP2

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

IGFBP2

Aliases

IBP2, IGF-BP53

Entrez Gene ID

3485

Gene Name

Insulin like growth factor binding protein 2

Chromosomal Location

2q35

HGNC ID

HGNC:5471

Summary

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

e!Ensembl

Gene	ENSG00000115457
Transcript	ENST00000434997, ENST00000233809, ENST00000456764, ENST00000436812
Protein	ENSP00000401698, ENSP00000233809, ENSP00000389646, ENSP00000400308

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IDA	15694994
GO:0043567	Biological process	Regulation of insulin-like growth factor receptor signaling pathway	IBA	21873635
GO:0043567	Biological process	Regulation of insulin-like growth factor receptor signaling pathway	IC	19081843
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	TAS	24431302
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	15694994
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0005102	Molecular function	Signaling receptor binding	TAS	24431302
GO:0005515	Molecular function	Protein binding	IPI	19095771
GO:0031994	Molecular function	Insulin-like growth factor I binding	IBA	21873635
GO:0031994	Molecular function	Insulin-like growth factor I binding	IDA	19081843
GO:0031995	Molecular function	Insulin-like growth factor II binding	IBA	21873635

Protein Information

Protein Name

Insulin-like growth factor-binding protein 2, IGF-binding protein 2, insulin-like growth factor binding protein 2, 36kDa

Function

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

UniProt

P18065

PDB

2H7T

Pfam

Pfam Accession	Pfam ID
PF00219	IGFBP
PF00086	Thyroglobulin_1

Pathways
	Reactome
		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Interactions

STRING	MINT	IntAct
ENSP00000305372	P07550	P07550

View interactions

Associated Diseases

Show/Hide all(6 )

Disease group	Disease Name	References
Digestive System Diseases
	Liver Cirrhosis	26396155
	Liver Fibrosis	26396155
Endocrine System Diseases
Endocrine System Diseases	PCOS	12095507
Neoplasms
	Salivary Gland Neoplasms	16762588
	Adenoid Cystic Carcinoma	16762588
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	Obesity	22537059
Psychiatric/Brain disorders
Psychiatric/Brain disorders	Bipolar Disorder	17230047, 17395163, 15762851
Skin and Connective Tissue Diseases
Skin and Connective Tissue Diseases	Dermatitis	25724174

References

Show/Hide all(3)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
12095507	IGFBP-1,IGFBP-4				Related		These results demonstrate that androgen and insulin are important regulators of IGFBP release and that elevated levels of the two hormones may contribute to the altered IGFBP profile found in PCOS follicles, compared with the case of estrogen-dominant follicles.
1383254	IGFBP-3,IGFBP-4 and TGF-beta				Related		The results of this studies indicate that IGFBP-2, IGFBP-4, and the 29K BP are significantly increased in PCO FF and that gonadotropins and TGF-beta regulate the production of IGFBPs by human theca and granulosa cells.
8530645	IGFBP-3,IGFBP-4	Atresia			Related		These data support the hypothesis that decreased concentrations of IGFBP, in particular IGFBP-3, may be involved in selection of the dominant follicle, and that when a spontaneous pre-ovulatory follicle develops in PCOS, the underlying cause of the polycystic ovaries is not resolved but the rest of the ovary remains polycystic.

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