IGFBP3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IGFBP3

Aliases

BP-53, IBP3

Entrez Gene ID

3486

Gene Name

Insulin like growth factor binding protein 3

Chromosomal Location

7p12.3

HGNC ID

HGNC:5472

Summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_011508.1

RefSeq mRNA

NM_001013398.2, NM_000598.5

e!Ensembl

Gene	ENSG00000146674
Transcript	ENST00000381086, ENST00000275521, ENST00000381083, ENST00000428530, ENST00000417621, ENST00000448817, ENST00000613132, ENST00000615754
Protein	ENSP00000370476, ENSP00000275521, ENSP00000370473, ENSP00000390298, ENSP00000399116, ENSP00000389668, ENSP00000477772, ENSP00000480717

Gene Ontology (GO)

Show/Hide all(23 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001933	Biological process	Negative regulation of protein phosphorylation	IDA	17591901
GO:0006468	Biological process	Protein phosphorylation	IDA	17434920
GO:0008285	Biological process	Negative regulation of cell proliferation	IGI	19258508
GO:0009968	Biological process	Negative regulation of signal transduction	NAS	11940579
GO:0014912	Biological process	Negative regulation of smooth muscle cell migration	IDA	10766744
GO:0043065	Biological process	Positive regulation of apoptotic process	IMP	11971816
GO:0043567	Biological process	Regulation of insulin-like growth factor receptor signaling pathway	IBA	21873635
GO:0045663	Biological process	Positive regulation of myoblast differentiation	IDA	12599210
GO:0048662	Biological process	Negative regulation of smooth muscle cell proliferation	IDA	10766744
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	17119061
GO:0005634	Cellular component	Nucleus	IDA	17434920
GO:0016942	Cellular component	Insulin-like growth factor binding protein complex	IC	10766744
GO:0042567	Cellular component	Insulin-like growth factor ternary complex	IDA	9497324
GO:0001968	Molecular function	Fibronectin binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	9388210, 14561895, 20353938, 23178489
GO:0005520	Molecular function	Insulin-like growth factor binding	NAS	12599210
GO:0008160	Molecular function	Protein tyrosine phosphatase activator activity	IDA	11940579
GO:0031994	Molecular function	Insulin-like growth factor I binding	IBA	21873635
GO:0031994	Molecular function	Insulin-like growth factor I binding	IPI	10766744
GO:0031995	Molecular function	Insulin-like growth factor II binding	IBA	21873635
GO:0046872	Molecular function	Metal ion binding	NAS	14576163

Protein Information

Protein Name

Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Refseq Proteins

NP_001013416.1, NP_000589.2

UniProt

P17936

Pfam

Pfam Accession	Pfam ID
PF00219	IGFBP
PF00086	Thyroglobulin_1