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Gene Symbol |
IGFBP4 |
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Aliases |
BP-4, HT29-IGFBP, IBP4, IGFBP-4 |
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Entrez Gene ID |
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Gene Name |
Insulin like growth factor binding protein 4 |
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Chromosomal Location |
17q21.2 |
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HGNC ID |
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Summary |
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
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e!Ensembl
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| Protein Information |
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Protein Name |
Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4 |
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Function |
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IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000265986 |
P14735 |
P14735 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Acute Coronary Syndrome |
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| Myocardial Infarction |
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| Cardiovascular Abnormalities |
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| Atherosclerosis |
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| Hypertensive disease |
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| Vascular Diseases |
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| Heart Failure |
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| Retinal Vein Occlusion |
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| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Biliary Atresia |
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| Nail patella syndrome |
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| Sotos syndrome |
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| Short Bowel Syndrome |
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| Digestive System Diseases |
| Inflammatory Bowel Diseases |
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| Peritoneal Fibrosis |
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| Liver Fibrosis |
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| Hepatitis |
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| Hepatitis C |
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| Liver Cirrhosis |
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| Endocrine System Diseases |
| PCOS |
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| Diabetes Insipidus |
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| Growth Hormone Deficiency |
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| Hyperparathyroidism |
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| Diabetes Mellitus |
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| Hyperthyroidism |
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| Congenital adrenal hyperplasia |
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| Leptin Deficiency |
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| Hypopituitarism |
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| Eye Diseases |
| Diabetic Retinopathy |
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| Myopia |
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| Immune System Diseases |
| Lupus Nephritis |
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| Autoimmune Diabetes |
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| Rheumatoid Arthritis |
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| Sarcoidosis |
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| Musculoskeletal Diseases |
| Osteoarthritis |
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| Intervertebral Disc Degeneration |
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| Necrosis |
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| Osteogenesis Imperfecta |
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| Osteoporosis |
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| Arthritis |
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| Osteoarthrosis Deformans |
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| Neoplasms |
| Breast Cancer |
17675285, 30388235, 7686749, 30348128, 22287600, 17287408, 1373605, 10395168, 10342835, 7690042, 8603400, 1379645, 1382838, 12926118, 7556169, 27141101, 9683795, 15182430, 10572248, 9815555, 7505280, 29603395, 7686909, 7683543, 11461068, 15072547, 31083221, 18928543, 29028222, 158200 |
| Osteosarcoma |
8636339, 11158056, 7521341, 1283479, 7506211, 11996908, 11914024, 7534697, 15155755, 7532581, 25613065, 9048882, 1707125, 7689570, 7685579, 1726835, 7527330, 9322936 |
| Glioblastoma |
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| Neuroblastoma |
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| Squamous Cell Carcinoma |
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| Adenocarcinoma |
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| Renal Cancer |
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| Colonic Neoplasms |
9311602, 8612513, 7527300, 8977421, 8592000, 14656210, 11807815, 7491929, 9218734, 11604234, 1709585, 7542277, 9731515, 9386991, 14585185, 14767471, 1281142 |
| Adenocarcinoma of Prostate |
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| Ovarian Cysts |
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| Uterine Fibroids |
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| Ovarian Cancer |
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| Colorectal Cancer |
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| Polycythemia vera |
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| Leukemia |
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| Endometrial Cancer |
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| Central Nervous System Neoplasms |
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| Skin Cancer |
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| Liver Cancer |
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| Carotid Atherosclerosis |
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| Prostate cancer |
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| Lung Cancer |
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| Multiple Sclerosis |
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| Hereditary Breast and Ovarian Cancer Syndrome |
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| Thyroid Cancer |
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| Gastric Cancer |
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| Glioma |
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| Hepatoblastoma |
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| Bone Neoplasms |
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| Seminoma |
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| Prostate Carcinoma |
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| Meningioma |
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| Nasopharyngeal Cancer |
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| Mesothelioma |
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| Multiple Myeloma |
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| Nervous System Diseases |
| Transient Ischemic Attack |
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| Muscular Dystrophy |
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| Lateral Sclerosis |
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| Stroke |
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| Diabetic Neuropathies |
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| Nutritional and Metabolic Diseases |
| Deficiency Diseases |
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| Obesity |
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| Hypoglycemia |
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| Insulin-Like Growth Factor I Deficiency |
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| Metabolic Bone Disorder |
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| Psychiatric/Brain disorders |
| Cognition Disorders |
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| Borderline Personality Disorder |
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| Eating Disorders |
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| Mood Disorders |
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| Renal Disorder |
| Kidney Failure |
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| Ascites |
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| Glomerular Hypertrophy |
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| Renal Osteodystrophy |
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| Reproductive disorders |
| Azoospermia |
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| Infertility |
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| Endometriosis |
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| Prostatic Hyperplasia |
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| Pregnancy associated hypertension |
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| Respiratory Tract Diseases |
| Asthma |
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| Pneumonia |
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| Pulmonary Fibrosis |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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IGFBPs |
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Related
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IGFBP-2, IGFBP-4, and the 29K BP are significantly increased in PCO FF |
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Related
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12womens with rgular menstrual cycle |
The decrease in IGF-I-mediated stimulation of gonadotropin actions on granulosa and theca cells in preantral and antral follicles may impair the induction of aromatase activity, causing an androgenic microenvironment which is characteristic of atretic follicles and PCOS follicles. |
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