IL10: Polycystic Ovarian Syndrome Database

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IL10

Gene Information

SNPs

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

IL10

Aliases

CSIF, GVHDS, IL-10, IL10A, TGIF

Entrez Gene ID

3586

Gene Name

Interleukin 10

Chromosomal Location

1q32.1

HGNC ID

HGNC:5962

Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

RefSeq DNA

NG_012088.1

RefSeq mRNA

NM_000572.3

e!Ensembl

Gene	ENSG00000136634
Transcript	ENST00000423557, ENST00000659642, ENST00000659065, ENST00000664374, ENST00000471071
Protein	ENSP00000412237, ENSP00000499509, ENSP00000499588, ENSP00000499664, ENSP00000493073

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
		C819T			27617227
		G1082A			27617227

Gene Ontology (GO)

Show/Hide all(47 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001818	Biological process	Negative regulation of cytokine production	IDA	1940799
GO:0002237	Biological process	Response to molecule of bacterial origin	IDA	17449476
GO:0002740	Biological process	Negative regulation of cytokine secretion involved in immune response	IDA	10443688
GO:0002904	Biological process	Positive regulation of B cell apoptotic process	IDA	9184696
GO:0006954	Biological process	Inflammatory response	IDA	10443688
GO:0007253	Biological process	Cytoplasmic sequestering of NF-kappaB	NAS	10975994
GO:0010468	Biological process	Regulation of gene expression	IDA	9184696
GO:0010507	Biological process	Negative regulation of autophagy	IDA	26962683
GO:0030097	Biological process	Hemopoiesis	TAS	11244051
GO:0030183	Biological process	B cell differentiation	NAS	8228801
GO:0030595	Biological process	Leukocyte chemotaxis	TAS	9405662
GO:0030889	Biological process	Negative regulation of B cell proliferation	IDA	9184696
GO:0032692	Biological process	Negative regulation of interleukin-1 production	TAS	19262501
GO:0032695	Biological process	Negative regulation of interleukin-12 production	TAS	19262501
GO:0032701	Biological process	Negative regulation of interleukin-18 production	TAS	19262501
GO:0032715	Biological process	Negative regulation of interleukin-6 production	IDA	10443688
GO:0032715	Biological process	Negative regulation of interleukin-6 production	TAS	19262501
GO:0032717	Biological process	Negative regulation of interleukin-8 production	TAS	19262501
GO:0032720	Biological process	Negative regulation of tumor necrosis factor production	TAS	19262501
GO:0032800	Biological process	Receptor biosynthetic process	IDA	10443688
GO:0042092	Biological process	Type 2 immune response	TAS	11244051
GO:0042100	Biological process	B cell proliferation	NAS	8228801
GO:0042130	Biological process	Negative regulation of T cell proliferation	NAS	8499633, 14971032
GO:0043066	Biological process	Negative regulation of apoptotic process	NAS	8312229
GO:0045191	Biological process	Regulation of isotype switching	NAS	8228801
GO:0045347	Biological process	Negative regulation of MHC class II biosynthetic process	IDA	1940799
GO:0045347	Biological process	Negative regulation of MHC class II biosynthetic process	TAS	11244051
GO:0045355	Biological process	Negative regulation of interferon-alpha biosynthetic process	NAS	9637497
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	7749983, 16606666
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	17875732
GO:0046427	Biological process	Positive regulation of JAK-STAT cascade	IDA	16982608
GO:0050715	Biological process	Positive regulation of cytokine secretion	IDA	10443688
GO:0050728	Biological process	Negative regulation of inflammatory response	NAS	21857966
GO:0051045	Biological process	Negative regulation of membrane protein ectodomain proteolysis	IDA	18383040
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IDA	7749983
GO:0051384	Biological process	Response to glucocorticoid	IDA	10443688
GO:0060302	Biological process	Negative regulation of cytokine activity	IMP	9847016
GO:0071222	Biological process	Cellular response to lipopolysaccharide	NAS	14971032
GO:0071650	Biological process	Negative regulation of chemokine (C-C motif) ligand 5 production	TAS	19262501
GO:1903659	Biological process	Regulation of complement-dependent cytotoxicity	IMP	16034134
GO:2000352	Biological process	Negative regulation of endothelial cell apoptotic process	IMP	16034134
GO:0005615	Cellular component	Extracellular space	IDA	10443688, 21323571
GO:0005125	Molecular function	Cytokine activity	NAS	10443688
GO:0005141	Molecular function	Interleukin-10 receptor binding	NAS	1847510
GO:0005515	Molecular function	Protein binding	IPI	11485736, 12513909, 15837194, 16982608, 20462497
GO:0008083	Molecular function	Growth factor activity	NAS	1371884
GO:0046983	Molecular function	Protein dimerization activity	IDA	16982608

Protein Information

Protein Name

Interleukin-10, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor

Function

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).

Refseq Proteins

NP_000563.1

UniProt

P22301

PDB

1J7V, 1Y6K, 1ILK, 1INR, 1LK3, 2H24, 2ILK

Pfam

Pfam Accession	Pfam ID
PF00726	IL10

Pathways
	KEGG	Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway Intestinal immune network for IgA production Pertussis Yersinia infection Leishmaniasis Chagas disease (American trypanosomiasis) African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Staphylococcus aureus infection Tuberculosis Asthma Autoimmune thyroid disease Inflammatory bowel disease (IBD) Systemic lupus erythematosus Allograft rejection	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis

Interactions

STRING	MINT	IntAct
ENSP00000303315	P17275	P17275

View interactions

Associated Diseases

Show/Hide all(13 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Myocardial Infarction	16310260, 15883752
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Wilson Disease	25002079
Digestive System Diseases
	Crohn Disease	21102463, 26974007
	Colitis	24314293, 19238344, 22119709, 21807089, 26974007, 20228798, 19915572, 20228799, 18836448, 27580383, 21102463
	Inflammatory Bowel Diseases	23291587, 28411859, 26192919
	Appendicitis	16367942
	Enteritis	21102463
	Irritable Bowel Syndrome	12404228
	Cholangitis	26974007
	Enterocolitis	17574631
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
	Brittle diabetes	19430480
	Diabetes Mellitus	19430480, 21980299
	Ketosis-prone diabetes	19430480
	PCOS	27617227
Immune System Diseases
	Lupus Erythematosus	19838195, 20728533, 26502338
	Behcet Syndrome	20622878, 23291587, 20622879
	Libman-Sacks Disease	19838195, 20728533
	HIV Infections	10202824
	Rheumatoid Arthritis	22450443
	HIV Coinfection	10202824
	Dermatitis	15347381
	Autoimmune Hepatitis	21227906
	Autoimmune Diabetes	19430480
Musculoskeletal Diseases
Musculoskeletal Diseases	Spondylitis	26974007
Neoplasms
	Lung Cancer	20471133, 14587096
	Prostate cancer	17999153, 16284379, 18174250
	Multiple Sclerosis	23517930
	Leukemia	23962110
Psychiatric/Brain disorders
	Schizophrenia	23951054, 21658228, 24603720, 21216474
	Mental Depression	23608119, 19786281
	Autistic Disorder	16360218
	Obstructive Sleep Apnea	28500380, 26139223, 25944984
Renal Disorder
	Kidney Failure	18460982
	Kidney Insufficiency	18460982
	Nephritis	10910440
	Glomerulonephritis	10910440
Reproductive disorders
	Chronic Prostatitis with Chronic Pelvic Pain Syndrome	12050565
	prostatitis	12050565
	Asymptomatic Inflammatory Prostatitis	12050565
	Bacterial Prostatitis	12050565
	Preeclampsia	24477695, 25317824, 29658087, 31010153, 23790133, 22182686, 30007972
Respiratory Tract Diseases
Respiratory Tract Diseases	Pleuritis	11181422
Skin and Connective Tissue Diseases
	Leishmaniasis	20102417, 16540374, 20404924
	Eczema	18249437
	Dermatitis	18249437
	Psoriasis	26974007

References

PMID: 27617227

Interleukin 10 (- 1082 G/A) and (- 819 C/T) gene polymorphisms in Egyptian women with polycystic ovary syndrome (PCOS).

Talaat Roba M, Mohamed Yasmin A, Mohamad Ehab H, Elsharkawy Marwa, Guirgis Adel A

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.| Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.| Obstetrics and Gynecology Department, Faculty of Medicine, Al-Azhar University, Egypt.| Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.| Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Meta Gene. 2016 Aug 3;9:254-8. doi: 10.1016/j.mgene.2016.08.001. eCollection 2016

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