IL12A

Gene Information
 
Gene Symbol
IL12A
 
Aliases
CLMF, IL-12A, NFSK, NKSF1, P35
 
Entrez Gene ID
 
Gene Name
Interleukin 12A
 
Chromosomal Location
3q25.33
 
HGNC ID
 
Summary
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001916 Biological process Positive regulation of T cell mediated cytotoxicity IDA 1674604, 2204066
GO:0002860 Biological process Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA 7903063
GO:0006955 Biological process Immune response TAS 9789052
GO:0007050 Biological process Cell cycle arrest IDA 16942485
GO:0009615 Biological process Response to virus IEP 16548883
Protein Information
 
Protein Name
Interleukin-12 subunit alpha, CLMF p35, IL-12, subunit p35, IL35 subunit, NF cell stimulatory factor chain 1, NK cell stimulatory factor chain 1, cytotoxic lymphocyte maturation factor 1, p35, cytotoxic lymphocyte maturation factor 35 kDa subunit, interleukin 12, p35, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), interleukin-12 alpha chain
 
Function
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
 
Refseq Proteins
 
UniProt
 
Pfam
Pfam Accession Pfam ID
PF03039 IL12
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex virus 1 infection
Pathways in cancer
Inflammatory bowel disease (IBD)
Allograft rejection

 

Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-35 Signalling
Interleukin-12 signaling

Interactions
 
STRING MINT IntAct
ENSP00000171111 Q14145 Q14145
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Biliary Cirrhosis
Endocrine System Diseases
PCOS
Immune System Diseases
Sicca Syndrome
Neoplasms
Multiple Sclerosis
Liver Cancer
References
 

Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome.

Nehir Aytan Asli, Bastu Ercan, Demiral Irem, Bulut Huri, Dogan Murat, Buyru Faruk
a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| b Department of Biochemistry , Bezmialem Foundation University, Faculty of Science , Istanbul , Turkey.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
Gynecol Endocrinol. 2016 Sep;32(9):709-713. doi: 10.3109/09513590.2016.1155208.

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