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Gene Symbol |
IL12A |
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Aliases |
CLMF, IL-12A, NFSK, NKSF1, P35 |
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Entrez Gene ID |
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Gene Name |
Interleukin 12A |
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Chromosomal Location |
3q25.33 |
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HGNC ID |
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Summary |
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0001916 |
Biological process |
Positive regulation of T cell mediated cytotoxicity |
IDA |
1674604, 2204066 |
| GO:0002860 |
Biological process |
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
IDA |
7903063 |
| GO:0006955 |
Biological process |
Immune response |
TAS |
9789052 |
| GO:0007050 |
Biological process |
Cell cycle arrest |
IDA |
16942485 |
| GO:0009615 |
Biological process |
Response to virus |
IEP |
16548883 |
| GO:0010224 |
Biological process |
Response to UV-B |
IDA |
8992506 |
| GO:0016477 |
Biological process |
Cell migration |
IDA |
7903063 |
| GO:0032496 |
Biological process |
Response to lipopolysaccharide |
IDA |
7605994, 8557999 |
| GO:0032700 |
Biological process |
Negative regulation of interleukin-17 production |
IDA |
16482511 |
| GO:0032729 |
Biological process |
Positive regulation of interferon-gamma production |
IDA |
1674604, 11114383, 19088061 |
| GO:0032816 |
Biological process |
Positive regulation of natural killer cell activation |
IDA |
1674604 |
| GO:0032946 |
Biological process |
Positive regulation of mononuclear cell proliferation |
IMP |
11023671 |
| GO:0034393 |
Biological process |
Positive regulation of smooth muscle cell apoptotic process |
IDA |
16942485 |
| GO:0042531 |
Biological process |
Positive regulation of tyrosine phosphorylation of STAT protein |
IDA |
12372421 |
| GO:0045785 |
Biological process |
Positive regulation of cell adhesion |
IDA |
7903063 |
| GO:0045954 |
Biological process |
Positive regulation of natural killer cell mediated cytotoxicity |
IDA |
2204066 |
| GO:0048662 |
Biological process |
Negative regulation of smooth muscle cell proliferation |
IDA |
16942485 |
| GO:0050671 |
Biological process |
Positive regulation of lymphocyte proliferation |
IDA |
1674604, 2204066 |
| GO:0050830 |
Biological process |
Defense response to Gram-positive bacterium |
IEP |
1357073 |
| GO:0051135 |
Biological process |
Positive regulation of NK T cell activation |
IDA |
19088061 |
| GO:0097191 |
Biological process |
Extrinsic apoptotic signaling pathway |
IDA |
16942485 |
| GO:0098586 |
Biological process |
Cellular response to virus |
IMP |
25754930 |
| GO:2000510 |
Biological process |
Positive regulation of dendritic cell chemotaxis |
IMP |
25754930 |
| GO:0005615 |
Cellular component |
Extracellular space |
IDA |
16456693 |
| GO:0043514 |
Cellular component |
Interleukin-12 complex |
IDA |
2204066, 11023671, 11114383 |
| GO:0043514 |
Cellular component |
Interleukin-12 complex |
NAS |
1674604, 14718574 |
| GO:0005125 |
Molecular function |
Cytokine activity |
IDA |
1674604 |
| GO:0005125 |
Molecular function |
Cytokine activity |
TAS |
1673147 |
| GO:0005143 |
Molecular function |
Interleukin-12 receptor binding |
NAS |
1674604 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
7527811, 10899108, 11023671 |
| GO:0008083 |
Molecular function |
Growth factor activity |
IDA |
1674604 |
| GO:0008083 |
Molecular function |
Growth factor activity |
NAS |
1673147 |
| GO:0042163 |
Molecular function |
Interleukin-12 beta subunit binding |
IPI |
11023671 |
| GO:0045513 |
Molecular function |
Interleukin-27 binding |
IPI |
9342359 |
| GO:0046982 |
Molecular function |
Protein heterodimerization activity |
IPI |
1674604, 11023671 |
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| Protein Information |
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Protein Name |
Interleukin-12 subunit alpha, CLMF p35, IL-12, subunit p35, IL35 subunit, NF cell stimulatory factor chain 1, NK cell stimulatory factor chain 1, cytotoxic lymphocyte maturation factor 1, p35, cytotoxic lymphocyte maturation factor 35 kDa subunit, interleukin 12, p35, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), interleukin-12 alpha chain |
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Function |
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Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
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UniProt |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF03039 |
IL12 |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000171111 |
Q14145 |
Q14145 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Biliary Cirrhosis |
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| Endocrine System Diseases |
| PCOS |
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| Immune System Diseases |
| Sicca Syndrome |
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| Neoplasms |
| Multiple Sclerosis |
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| Liver Cancer |
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| Glioma |
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| Vulvar Cancer |
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References |
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| Nehir Aytan Asli, Bastu Ercan, Demiral Irem, Bulut Huri, Dogan Murat, Buyru Faruk |
| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| b Department of Biochemistry , Bezmialem Foundation University, Faculty of Science , Istanbul , Turkey.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and. |
| Gynecol Endocrinol. 2016 Sep;32(9):709-713. doi: 10.3109/09513590.2016.1155208. |
Abstract
This prospective study aimed to determine the status of circulating levels of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), IL-27, IL-35, IL-37, alpha-1 acid glycoprotein in patients with polycystic ovary syndrome (PCOS) compared with controls and to evaluate their relation with hyperandrogenism and obesity. Forty-eight patients with PCOS (29 obese, 19 lean) and 40 healthy controls (20 obese, 20 lean) were enrolled. CRP, TNF-alpha, IL-27, IL-35, IL-37, alpha-1 acid glycoprotein, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S) levels were measured. Levels of total testosterone, A4, DHEA-S were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while levels of SHBG were significantly lower in all patients with PCOS than in all (p < 0.05). Free androgen index (FAI) values were significantly higher in all patients with PCOS than in all controls (all p < 0.05). Levels of CRP, TNF-alpha, alpha-1 acid glycoprotein were significantly increased in all patients with PCOS compared with all controls (all p < 0.001). FAI had a positive correlation with CRP, TNF-alpha, alpha-1 acid glycoprotein, a negative correlation with IL-27, IL-25, IL-37 (all p < 0.01). Body mass index had a negative correlation with IL-27, IL-35, IL-37, a positive correlation with alpha-1 acid glycoprotein, FAI (p < 0.05). The findings confirm the proinflammatory state of PCOS. Moreover, obesity along with PCOS significantly elevates the inflammatory status and hyperandrogenism. |
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