IL18: Polycystic Ovarian Syndrome Database

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IL18

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

IL18

Aliases

IGIF, IL-18, IL-1g, IL1F4

Entrez Gene ID

3606

Gene Name

Interleukin 18

Chromosomal Location

11q23.1

HGNC ID

HGNC:5986

Summary

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

RefSeq DNA

NG_028143.1

RefSeq mRNA

NM_001562.4, NM_001243211.2

e!Ensembl

Gene	ENSG00000150782
Transcript	ENST00000280357, ENST00000524595, ENST00000528832
Protein	ENSP00000280357, ENSP00000434561, ENSP00000434161

Gene Ontology (GO)

Show/Hide all(40 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000165	Biological process	MAPK cascade	IMP	21147091
GO:0001525	Biological process	Angiogenesis	IDA	11466388
GO:0006954	Biological process	Inflammatory response	IDA	21147091
GO:0007267	Biological process	Cell-cell signaling	TAS	9792649
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IDA	21321938
GO:0030155	Biological process	Regulation of cell adhesion	IDA	11477102
GO:0030431	Biological process	Sleep	ISS	11506998
GO:0031663	Biological process	Lipopolysaccharide-mediated signaling pathway	IDA	21147091
GO:0032148	Biological process	Activation of protein kinase B activity	IDA	21321938
GO:0032725	Biological process	Positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	20027291
GO:0032729	Biological process	Positive regulation of interferon-gamma production	IDA	10653850, 14528293, 19088061, 20027291
GO:0032740	Biological process	Positive regulation of interleukin-17 production	IDA	16482511
GO:0032819	Biological process	Positive regulation of natural killer cell proliferation	IDA	19088061
GO:0034105	Biological process	Positive regulation of tissue remodeling	IC	16482511
GO:0035655	Biological process	Interleukin-18-mediated signaling pathway	IDA	21321938, 25500532
GO:0042033	Biological process	Chemokine biosynthetic process	TAS	11598150
GO:0042088	Biological process	T-helper 1 type immune response	IDA	8766574
GO:0042092	Biological process	Type 2 immune response	TAS	11905033
GO:0042094	Biological process	Interleukin-2 biosynthetic process	TAS	10653850
GO:0042095	Biological process	Interferon-gamma biosynthetic process	TAS	10227975
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IDA	8766574
GO:0042231	Biological process	Interleukin-13 biosynthetic process	TAS	10227975
GO:0042253	Biological process	Granulocyte macrophage colony-stimulating factor biosynthetic process	TAS	10653850
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	10903731
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	24615654
GO:0048661	Biological process	Positive regulation of smooth muscle cell proliferation	IDA	21321938
GO:0050729	Biological process	Positive regulation of inflammatory response	IC	16482511
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	25500532
GO:0051142	Biological process	Positive regulation of NK T cell proliferation	IDA	19088061
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	21321938
GO:0071407	Biological process	Cellular response to organic cyclic compound	IDA	21147091
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	26656097
GO:0150078	Biological process	Positive regulation of neuroinflammatory response	TAS	26753638
GO:2000556	Biological process	Positive regulation of T-helper 1 cell cytokine production	IDA	10653850
GO:0005576	Cellular component	Extracellular region	TAS	11598150
GO:0005615	Cellular component	Extracellular space	IDA	21323571
GO:0005125	Molecular function	Cytokine activity	IDA	14528293, 25500532
GO:0005125	Molecular function	Cytokine activity	TAS	11598150
GO:0005515	Molecular function	Protein binding	IPI	19104048, 25261253
GO:0045515	Molecular function	Interleukin-18 receptor binding	IDA	14528293, 25500532

Protein Information

Protein Name

Interleukin-18, IFN-gamma-inducing factor, IL-1 gamma, iboctadekin, interleukin 18 (interferon-gamma-inducing factor), interleukin-1 gamma

Function

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).

Refseq Proteins

NP_001553.1, NP_001230140.1

UniProt

Q14116

PDB

3WO4, 3WO3, 4R6U, 1J0S, 2VXT, 3F62, 3WO2, 4EEE, 4EKX, 4HJJ, 4XFS, 4XFT, 4XFU

Pfam

Pfam Accession	Pfam ID
PF00340	IL1

Pathways
	KEGG	Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway Salmonella infection Legionellosis Yersinia infection African trypanosomiasis Malaria Tuberculosis Influenza A Inflammatory bowel disease (IBD) Rheumatoid arthritis	Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection

Interactions

STRING	MINT	IntAct
ENSP00000237014	P02766	P02766

View interactions

Associated Diseases

Show/Hide all(13 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Heart Diseases	21335463
Digestive System Diseases
	Liver Diseases	19164858
	Hepatitis	19164858
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
Endocrine System Diseases	PCOS	21244650
Immune System Diseases
	Sarcoidosis	16100009
	Autoimmune Hepatitis	21227906
	Rheumatoid Arthritis	16368150
	Urticaria	18204966
	Dermatitis	27585668
Neoplasms
	Mouth Neoplasms	24349532
	Prostate cancer	17688413
Nervous System Diseases
Nervous System Diseases	Cerebral Ischemia	15829914
Nutritional and Metabolic Diseases
	Tumoral calcinosis	21335463
	Metabolic Syndrome X	16644639
	Gluocose Intolerance	22226490, 18448614
Psychiatric/Brain disorders
	Mental Depression	21962565, 11226333, 16289586
	Schizophrenia	18092318, 21510800
Renal Disorder
	Glomerulonephritis	18462998
	Nephritis	18462998
Reproductive disorders
Reproductive disorders	Preeclampsia	26711734, 31010153, 26053021
Respiratory Tract Diseases
Respiratory Tract Diseases	Pneumonia	21625544
Skin and Connective Tissue Diseases
	Leishmaniasis	16879623
	Dermatitis	25724174

References

Show/Hide all(7)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
21244650		Insulin resistance,obesity,hyperandrogenism & low-grade chronic inflammation		Rotterdam criteria	Related		IL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism
19131059	Plasminogen activator inhibitor-1,tumor necrosis factor- gene,C-reactive protein	Carotid intima-media wall thickness,cardiovascular risk factors		Rotterdam criteria	Related		Elevated serum IL-18 levels were associated with cardiovascular risk factors and carotid IMT in patients with PCOS
22553983	Plasminogen activator inhibitor-1	Obesity,insulin resistance			Related		Interleukin 18 (IL-18) is elevated in lean patients, with a further rise in the presence of obesity and insulin resistance.
22226490		Glucose intolerance,Obesity,insulin resistance	IL-18 gene polymorphisms -137G>C(associated) and +183A>G(not associated)		Related	Korean -126 Pcos patients and 113 controls	The IL-18 -137G allele could play a role in the predisposition to glucose intolerance in Korean women with PCOS, and the +183G allele of IL-18 is not associated with the Korean population
17308143	C-reactive protein,IL-6	Atherosclerosis,coronary heart disease,type 2 diabetes			Related		Evidence of low-grade chronic inflammation in PCOS is indicated by the presence of elevated C-reactive protein (CRP) levels, inflammatory cytokines (i.e., IL-6 and IL-18), and increased leucocyte count.
14764799		Obesity,insulin resistance		NIH	Related		In conclusion, PCOS and obesity induce an increase in serum IL-18 levels, which are also associated with several indexes of global and visceral adiposity and with insulin resistance.
16943580		PCOS, Insulin resistance			Related	30 PCOS,11 controls	This study indicates that IL-18 may be a contributing factor linking inflammation and insulin resistance in PCOS women

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