IL1B: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IL1B

Aliases

IL-1, IL1-BETA, IL1F2, IL1beta

Entrez Gene ID

3553

Gene Name

Interleukin 1 beta

Chromosomal Location

2q14.1

HGNC ID

HGNC:5992

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008851.1

RefSeq mRNA

NM_000576.3

e!Ensembl

Gene	ENSG00000125538
Transcript	ENST00000263341, ENST00000418817, ENST00000432018, ENST00000416750
Protein	ENSP00000263341, ENSP00000407219, ENSP00000409680, ENSP00000400854

Gene Ontology (GO)

Show/Hide all(103 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000165	Biological process	MAPK cascade	IMP	21147091
GO:0000187	Biological process	Activation of MAPK activity	IDA	10748004
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IDA	10748004
GO:0001934	Biological process	Positive regulation of protein phosphorylation	NAS	16477012
GO:0002711	Biological process	Positive regulation of T cell mediated immunity	IC	1919436
GO:0006915	Biological process	Apoptotic process	TAS	9218611
GO:0006954	Biological process	Inflammatory response	IDA	10748004, 21147091
GO:0006954	Biological process	Inflammatory response	NAS	1919436
GO:0007165	Biological process	Signal transduction	TAS	9218611, 10786823
GO:0007267	Biological process	Cell-cell signaling	TAS	2989698
GO:0007566	Biological process	Embryo implantation	TAS	16720713
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	25204733
GO:0008285	Biological process	Negative regulation of cell proliferation	IDA	3493774
GO:0010575	Biological process	Positive regulation of vascular endothelial growth factor production	IBA	21873635
GO:0010575	Biological process	Positive regulation of vascular endothelial growth factor production	IDA	12958148
GO:0010628	Biological process	Positive regulation of gene expression	IBA	21873635
GO:0010628	Biological process	Positive regulation of gene expression	IDA	21559518, 23817958, 26687115, 29384235
GO:0010628	Biological process	Positive regulation of gene expression	IGI	29384235
GO:0010718	Biological process	Positive regulation of epithelial to mesenchymal transition	IDA	25204733
GO:0010829	Biological process	Negative regulation of glucose transmembrane transport	ISS	16865359
GO:0014805	Biological process	Smooth muscle adaptation	NAS	16477012
GO:0019221	Biological process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Biological process	Cytokine-mediated signaling pathway	IDA	10748004
GO:0030213	Biological process	Hyaluronan biosynthetic process	IDA	15100360
GO:0030335	Biological process	Positive regulation of cell migration	IDA	25204733
GO:0030593	Biological process	Neutrophil chemotaxis	IBA	21873635
GO:0030730	Biological process	Sequestering of triglyceride	IDA	19032770
GO:0030949	Biological process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	IC	12958148
GO:0031394	Biological process	Positive regulation of prostaglandin biosynthetic process	IGI	29384235
GO:0031663	Biological process	Lipopolysaccharide-mediated signaling pathway	IDA	21147091
GO:0032496	Biological process	Response to lipopolysaccharide	IDA	19193853
GO:0032725	Biological process	Positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	20027291
GO:0032729	Biological process	Positive regulation of interferon-gamma production	IDA	10653850, 20027291
GO:0032755	Biological process	Positive regulation of interleukin-6 production	IBA	21873635
GO:0032755	Biological process	Positive regulation of interleukin-6 production	IGI	29384235
GO:0032755	Biological process	Positive regulation of interleukin-6 production	TAS	16865359
GO:0032757	Biological process	Positive regulation of interleukin-8 production	IDA	19524870
GO:0033129	Biological process	Positive regulation of histone phosphorylation	NAS	20018936
GO:0034116	Biological process	Positive regulation of heterotypic cell-cell adhesion	IDA	15100360
GO:0034116	Biological process	Positive regulation of heterotypic cell-cell adhesion	NAS	19281832
GO:0035066	Biological process	Positive regulation of histone acetylation	NAS	20018936
GO:0035505	Biological process	Positive regulation of myosin light chain kinase activity	IDA	18390750
GO:0035690	Biological process	Cellular response to drug	IDA	19158679
GO:0042102	Biological process	Positive regulation of T cell proliferation	IDA	1919436
GO:0043122	Biological process	Regulation of I-kappaB kinase/NF-kappaB signaling	IDA	10748004
GO:0043123	Biological process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043407	Biological process	Negative regulation of MAP kinase activity	ISS	16865359
GO:0043491	Biological process	Protein kinase B signaling	IMP	21147091
GO:0045086	Biological process	Positive regulation of interleukin-2 biosynthetic process	IMP	2989698
GO:0045429	Biological process	Positive regulation of nitric oxide biosynthetic process	IDA	8383325
GO:0045766	Biological process	Positive regulation of angiogenesis	IBA	21873635
GO:0045766	Biological process	Positive regulation of angiogenesis	IDA	25204733
GO:0045833	Biological process	Negative regulation of lipid metabolic process	ISS	16865359
GO:0045840	Biological process	Positive regulation of mitotic nuclear division	IMP	2989698
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	15100360
GO:0045917	Biological process	Positive regulation of complement activation	IGI	29384235
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046330	Biological process	Positive regulation of JNK cascade	IBA	21873635
GO:0046627	Biological process	Negative regulation of insulin receptor signaling pathway	ISS	16865359
GO:0046827	Biological process	Positive regulation of protein export from nucleus	NAS	19281832
GO:0050729	Biological process	Positive regulation of inflammatory response	IGI	29384235
GO:0050766	Biological process	Positive regulation of phagocytosis	IMP	18201371
GO:0050768	Biological process	Negative regulation of neurogenesis	TAS	20018408
GO:0050796	Biological process	Regulation of insulin secretion	IDA	8383325
GO:0050995	Biological process	Negative regulation of lipid catabolic process	IDA	19032770
GO:0050996	Biological process	Positive regulation of lipid catabolic process	ISS	16865359
GO:0050999	Biological process	Regulation of nitric-oxide synthase activity	IBA	21873635
GO:0050999	Biological process	Regulation of nitric-oxide synthase activity	IDA	15899045
GO:0051044	Biological process	Positive regulation of membrane protein ectodomain proteolysis	IDA	18373975
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IDA	10748004
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	10383454, 12958148
GO:0060252	Biological process	Positive regulation of glial cell proliferation	IGI	1752215
GO:0060355	Biological process	Positive regulation of cell adhesion molecule production	NAS	19281832
GO:0060559	Biological process	Positive regulation of calcidiol 1-monooxygenase activity	IDA	16720713, 17023519
GO:0070164	Biological process	Negative regulation of adiponectin secretion	ISS	16865359
GO:0070372	Biological process	Regulation of ERK1 and ERK2 cascade	IDA	25204733
GO:0070487	Biological process	Monocyte aggregation	IDA	15100360
GO:0070555	Biological process	Response to interleukin-1	IDA	29441883
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071260	Biological process	Cellular response to mechanical stimulus	IEP	19593445
GO:0071310	Biological process	Cellular response to organic substance	IDA	19158679
GO:0071407	Biological process	Cellular response to organic cyclic compound	IDA	21147091
GO:0071639	Biological process	Positive regulation of monocyte chemotactic protein-1 production	IDA	19524870
GO:0150078	Biological process	Positive regulation of neuroinflammatory response	TAS	26753638
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	IDA	18390750
GO:1902680	Biological process	Positive regulation of RNA biosynthetic process	IDA	29384235
GO:1903140	Biological process	Regulation of establishment of endothelial barrier	IDA	25816133
GO:2000556	Biological process	Positive regulation of T-helper 1 cell cytokine production	IDA	10653850
GO:2001240	Biological process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	10748004
GO:0005576	Cellular component	Extracellular region	IDA	20041150
GO:0005576	Cellular component	Extracellular region	NAS	1919436
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	12483741
GO:0005615	Cellular component	Extracellular space	IMP	3493774
GO:0030141	Cellular component	Secretory granule	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IDA	1919436
GO:0005125	Molecular function	Cytokine activity	IMP	2989698
GO:0005149	Molecular function	Interleukin-1 receptor binding	IBA	21873635
GO:0005149	Molecular function	Interleukin-1 receptor binding	NAS	1919436
GO:0005178	Molecular function	Integrin binding	IDA	29030430
GO:0005515	Molecular function	Protein binding	IPI	15817483
GO:0019904	Molecular function	Protein domain specific binding	IPI	16575408

Protein Information

Protein Name

Interleukin-1 beta, IL-1 beta, catabolin, interleukin 1beta, preinterleukin 1 beta, pro-interleukin-1-beta

Function

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Refseq Proteins

NP_000567.1

UniProt

P01584

PDB

3O4O, 4DEP, 1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3LTQ, 3POK, 41BI, 4G6J, 4G6M, 4GAF, 4GAI, 4I1B, 5BVP, 5I1B, 5MVZ, 6I1B, 7I1B, 9ILB

Pfam

Pfam Accession	Pfam ID
PF00340	IL1
PF02394	IL1_propep