IL23A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IL23A

Aliases

IL-23, IL-23A, IL23P19, P19, SGRF

Entrez Gene ID

51561

Gene Name

Interleukin 23 subunit alpha

Chromosomal Location

12q13.3

HGNC ID

HGNC:15488

Summary

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000110944
Transcript	ENST00000228534
Protein	ENSP00000228534

Gene Ontology (GO)

Show/Hide all(36 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002230	Biological process	Positive regulation of defense response to virus by host	IDA	12421946
GO:0002827	Biological process	Positive regulation of T-helper 1 type immune response	IDA	15114670
GO:0002827	Biological process	Positive regulation of T-helper 1 type immune response	NAS	20027291
GO:0002827	Biological process	Positive regulation of T-helper 1 type immune response	TAS	16751425
GO:0010536	Biological process	Positive regulation of activation of Janus kinase activity	IBA	21873635
GO:0010536	Biological process	Positive regulation of activation of Janus kinase activity	IDA	12023369
GO:0032693	Biological process	Negative regulation of interleukin-10 production	IMP	16751425
GO:0032725	Biological process	Positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	20027291
GO:0032729	Biological process	Positive regulation of interferon-gamma production	IDA	11114383, 17888176, 20027291
GO:0032729	Biological process	Positive regulation of interferon-gamma production	TAS	19088061
GO:0032733	Biological process	Positive regulation of interleukin-10 production	IDA	15265908
GO:0032733	Biological process	Positive regulation of interleukin-10 production	TAS	18675459
GO:0032735	Biological process	Positive regulation of interleukin-12 production	IDA	20027291
GO:0032740	Biological process	Positive regulation of interleukin-17 production	IDA	16482511, 16751425, 17888176
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IMP	16751425
GO:0032816	Biological process	Positive regulation of natural killer cell activation	IC	20027291
GO:0032819	Biological process	Positive regulation of natural killer cell proliferation	IDA	19088061
GO:0034105	Biological process	Positive regulation of tissue remodeling	IC	16482511
GO:0042102	Biological process	Positive regulation of T cell proliferation	IBA	21873635
GO:0042102	Biological process	Positive regulation of T cell proliferation	IDA	12023369
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IDA	11114383
GO:0042509	Biological process	Regulation of tyrosine phosphorylation of STAT protein	IDA	12023369
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	12023369, 19088061
GO:0045672	Biological process	Positive regulation of osteoclast differentiation	IDA	17888176
GO:0050729	Biological process	Positive regulation of inflammatory response	IC	16482511
GO:0050829	Biological process	Defense response to Gram-negative bacterium	IDA	15114670, 20027291
GO:0051135	Biological process	Positive regulation of NK T cell activation	IC	20027291
GO:0051135	Biological process	Positive regulation of NK T cell activation	IDA	19088061
GO:0051142	Biological process	Positive regulation of NK T cell proliferation	IDA	19088061
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	TAS	20428758
GO:2000330	Biological process	Positive regulation of T-helper 17 cell lineage commitment	IBA	21873635
GO:0070743	Cellular component	Interleukin-23 complex	IBA	21873635
GO:0070743	Cellular component	Interleukin-23 complex	IDA	11114383
GO:0005515	Molecular function	Protein binding	IPI	11114383, 12023369, 18680750, 25416956, 29997244
GO:0045519	Molecular function	Interleukin-23 receptor binding	IBA	21873635
GO:0045519	Molecular function	Interleukin-23 receptor binding	IDA	11114383

Protein Information

Protein Name

Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, IL-23p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19, interleukin-23 subunit p19, interleukin-six, G-CSF related factor

Function

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

UniProt

Q9NPF7

PDB

3D85, 3D87, 3DUH, 3QWR, 4GRW, 5MJ3, 5MJ4, 5MXA, 5MZV, 5NJD

Pfam

Pfam Accession	Pfam ID
PF16649	IL23