IL27

Gene Information
 
Gene Symbol
IL27
 
Aliases
IL-27, IL-27A, IL27A, IL27p28, IL30, p28
 
Entrez Gene ID
 
Gene Name
Interleukin 27
 
Chromosomal Location
16p12.1-p11.2
 
HGNC ID
 
Summary
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0042129 Biological process Regulation of T cell proliferation IBA 21873635
GO:0045078 Biological process Positive regulation of interferon-gamma biosynthetic process IBA 21873635
GO:0045078 Biological process Positive regulation of interferon-gamma biosynthetic process IDA 12734330
GO:0045625 Biological process Regulation of T-helper 1 cell differentiation IBA 21873635
GO:0045625 Biological process Regulation of T-helper 1 cell differentiation IDA 12734330
Protein Information
 
Protein Name
Interleukin-27 subunit alpha, IL-27 p28 subunit, IL-27 subunit alpha, IL-27-A, IL27-A, interleukin-30
 
Function
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.
 
UniProt
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction

  

Interleukin-27 signaling
Interactions
 
STRING MINT IntAct
ENSP00000454071 P01130 P01130
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Cholangitis
Crohn Disease
Inflammatory Bowel Diseases
Colitis
Endocrine System Diseases
Diabetes Mellitus
References
 

Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome.

Nehir Aytan Asli, Bastu Ercan, Demiral Irem, Bulut Huri, Dogan Murat, Buyru Faruk
a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| b Department of Biochemistry , Bezmialem Foundation University, Faculty of Science , Istanbul , Turkey.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
Gynecol Endocrinol. 2016 Sep;32(9):709-713. doi: 10.3109/09513590.2016.1155208.
Statistics
About BIC
Feedback
Links
Contact Us

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412