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Gene Symbol |
IL37 |
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Aliases |
FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1 |
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Entrez Gene ID |
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Gene Name |
Interleukin 37 |
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Chromosomal Location |
2q14.1 |
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HGNC ID |
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Summary |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Interleukin-37, FIL1 zeta, IL-1 zeta, IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1X protein, IL1F7 (canonical product IL-1F7b), interleukin 1 family member 7, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1 superfamily z, interleukin-1-related protein, interleukin-23 |
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Function |
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Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000262290 |
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P22079 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Atherosclerosis |
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| Arteriosclerosis |
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| Digestive System Diseases |
| Colitis |
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| Endocrine System Diseases |
| Diabetes Mellitus |
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| PCOS |
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| Eye Diseases |
| Retinal Diseases |
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| Immune System Diseases |
| Autoimmune Diseases |
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| Lupus Erythematosus |
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| Hashimoto Disease |
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| Graves Disease |
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| Rheumatoid Arthritis |
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| Musculoskeletal Diseases |
| Spondylitis |
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| Osteoporosis |
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| Neoplasms |
| Lung Cancer |
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| Colonic Neoplasms |
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| Nutritional and Metabolic Diseases |
| Obesity |
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| Reproductive disorders |
| Endometriosis |
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| Respiratory Tract Diseases |
| Asthma |
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| Pneumonia |
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| Skin and Connective Tissue Diseases |
| Psoriasis |
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| Eczema |
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| Dermatitis |
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References |
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| Nehir Aytan Asli, Bastu Ercan, Demiral Irem, Bulut Huri, Dogan Murat, Buyru Faruk |
| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| b Department of Biochemistry , Bezmialem Foundation University, Faculty of Science , Istanbul , Turkey.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.| a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and. |
| Gynecol Endocrinol. 2016 Sep;32(9):709-713. doi: 10.3109/09513590.2016.1155208. |
Abstract
This prospective study aimed to determine the status of circulating levels of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), IL-27, IL-35, IL-37, alpha-1 acid glycoprotein in patients with polycystic ovary syndrome (PCOS) compared with controls and to evaluate their relation with hyperandrogenism and obesity. Forty-eight patients with PCOS (29 obese, 19 lean) and 40 healthy controls (20 obese, 20 lean) were enrolled. CRP, TNF-alpha, IL-27, IL-35, IL-37, alpha-1 acid glycoprotein, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S) levels were measured. Levels of total testosterone, A4, DHEA-S were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while levels of SHBG were significantly lower in all patients with PCOS than in all (p < 0.05). Free androgen index (FAI) values were significantly higher in all patients with PCOS than in all controls (all p < 0.05). Levels of CRP, TNF-alpha, alpha-1 acid glycoprotein were significantly increased in all patients with PCOS compared with all controls (all p < 0.001). FAI had a positive correlation with CRP, TNF-alpha, alpha-1 acid glycoprotein, a negative correlation with IL-27, IL-25, IL-37 (all p < 0.01). Body mass index had a negative correlation with IL-27, IL-35, IL-37, a positive correlation with alpha-1 acid glycoprotein, FAI (p < 0.05). The findings confirm the proinflammatory state of PCOS. Moreover, obesity along with PCOS significantly elevates the inflammatory status and hyperandrogenism. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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