Gene Symbol

IL5

Aliases

EDF, IL-5, TRF

Entrez Gene ID

3567

Gene Name

Interleukin 5

Chromosomal Location

5q31.1

HGNC ID

HGNC:6016

Summary

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

Function

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells

P05113

PDB

3QT2, 3VA2, 1HUL

STRING	MINT	IntAct
ENSP00000219070	P08253	P08253