Gene Information
Gene Symbol
CD130, CDW130, GP130, HIES4, IL-6RB, sGP130
Entrez Gene ID
Gene Name
Interleukin 6 signal transducer
Chromosomal Location
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0002675 Biological process Positive regulation of acute inflammatory response IC 8999038
GO:0002821 Biological process Positive regulation of adaptive immune response IC 14764690
GO:0008284 Biological process Positive regulation of cell proliferation IBA 21873635
GO:0008284 Biological process Positive regulation of cell proliferation IDA 2261637
GO:0008284 Biological process Positive regulation of cell proliferation IGI 8999038
Protein Information
Protein Name
Interleukin-6 receptor subunit beta, CD130 antigen, IL-6 receptor subunit beta, IL-6R subunit beta, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, gp130, oncostatin M receptor, interleukin receptor beta chain, membrane glycoprotein 130, membrane glycoprotein gp130, oncostatin-M receptor subunit alpha
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Pfam Accession Pfam ID
PF00041 fn3
PF09240 IL6Ra-bind
PF06328 Lep_receptor_Ig

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Signaling pathways regulating pluripotency of stem cells
JAK-STAT signaling pathway
Th17 cell differentiation
Kaposi sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis


Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling

ENSP00000334145 P13726
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Myocardial Ischemia
Endocrine System Diseases
Immune System Diseases
Rheumatoid Arthritis
Prostate cancer

Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome.

Nikolajuk Agnieszka, Kowalska Irina, Karczewska-Kupczewska Monika, Adamska Agnieszka, Otziomek Elzbieta, Wolczynski Slawomir, Kinalska Ida, Gorska Maria, Straczkowski Marek
Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
Diabetes. 2010 Apr;59(4):1026-9. doi: 10.2337/db09-1316. Epub 2010 Jan 26.

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