IL6ST: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

IL6ST

Aliases

CD130, CDW130, GP130, HIES4, IL-6RB, sGP130

Entrez Gene ID

3572

Gene Name

Interleukin 6 signal transducer

Chromosomal Location

5q11.2

HGNC ID

HGNC:6021

Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

e!Ensembl

Gene	ENSG00000134352
Transcript	ENST00000381298, ENST00000651614, ENST00000503773, ENST00000502326, ENST00000381294, ENST00000381293, ENST00000381286, ENST00000522633, ENST00000381287, ENST00000336909, ENST00000396816
Protein	ENSP00000370698, ENSP00000498224, ENSP00000426224, ENSP00000462158, ENSP00000370694, ENSP00000370693, ENSP00000370686, ENSP00000435399, ENSP00000370687, ENSP00000338799, ENSP00000463896

Gene Ontology (GO)

Show/Hide all(51 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002675	Biological process	Positive regulation of acute inflammatory response	IC	8999038
GO:0002821	Biological process	Positive regulation of adaptive immune response	IC	14764690
GO:0008284	Biological process	Positive regulation of cell proliferation	IBA	21873635
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	2261637
GO:0008284	Biological process	Positive regulation of cell proliferation	IGI	8999038
GO:0010575	Biological process	Positive regulation of vascular endothelial growth factor production	TAS	10744750
GO:0010613	Biological process	Positive regulation of cardiac muscle hypertrophy	TAS	10744750
GO:0019221	Biological process	Cytokine-mediated signaling pathway	IDA	2261637
GO:0034097	Biological process	Response to cytokine	IDA	2261637, 8999038
GO:0038165	Biological process	Oncostatin-M-mediated signaling pathway	IMP	8999038
GO:0042102	Biological process	Positive regulation of T cell proliferation	IBA	21873635
GO:0042102	Biological process	Positive regulation of T cell proliferation	IMP	14764690
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IBA	21873635
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IMP	14764690
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	17530315
GO:0045669	Biological process	Positive regulation of osteoblast differentiation	IMP	12372336
GO:0048861	Biological process	Leukemia inhibitory factor signaling pathway	IDA	8999038, 12643274
GO:0070102	Biological process	Interleukin-6-mediated signaling pathway	IMP	2261637, 12643274
GO:0070106	Biological process	Interleukin-27-mediated signaling pathway	IMP	14764690
GO:0070120	Biological process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274
GO:0005896	Cellular component	Interleukin-6 receptor complex	IBA	21873635
GO:0005896	Cellular component	Interleukin-6 receptor complex	IDA	2261637, 12643274, 12829785
GO:0005900	Cellular component	Oncostatin-M receptor complex	IBA	21873635
GO:0005900	Cellular component	Oncostatin-M receptor complex	IDA	8999038
GO:0009897	Cellular component	External side of plasma membrane	IBA	21873635
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0043235	Cellular component	Receptor complex	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0070110	Cellular component	Ciliary neurotrophic factor receptor complex	IBA	21873635
GO:0070110	Cellular component	Ciliary neurotrophic factor receptor complex	IDA	12707266
GO:0004896	Molecular function	Cytokine receptor activity	IBA	21873635
GO:0004897	Molecular function	Ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0004915	Molecular function	Interleukin-6 receptor activity	IBA	21873635
GO:0004915	Molecular function	Interleukin-6 receptor activity	IDA	2261637, 12643274
GO:0004923	Molecular function	Leukemia inhibitory factor receptor activity	IBA	21873635
GO:0004923	Molecular function	Leukemia inhibitory factor receptor activity	IDA	8999038, 12643274
GO:0004924	Molecular function	Oncostatin-M receptor activity	IBA	21873635
GO:0004924	Molecular function	Oncostatin-M receptor activity	IDA	8999038
GO:0005127	Molecular function	Ciliary neurotrophic factor receptor binding	IBA	21873635
GO:0005127	Molecular function	Ciliary neurotrophic factor receptor binding	IPI	12707266
GO:0005138	Molecular function	Interleukin-6 receptor binding	IBA	21873635
GO:0005138	Molecular function	Interleukin-6 receptor binding	IPI	12829785
GO:0005515	Molecular function	Protein binding	IPI	8662591, 8999038, 10982829, 11238858, 14527405, 16051226, 18775332, 24407287, 24501689
GO:0019838	Molecular function	Growth factor binding	IPI	8999038
GO:0019838	Molecular function	Growth factor binding	IPI	8999038
GO:0019955	Molecular function	Cytokine binding	IBA	21873635
GO:0019981	Molecular function	Interleukin-6 binding	IBA	21873635
GO:0019981	Molecular function	Interleukin-6 binding	IPI	12829785
GO:0042802	Molecular function	Identical protein binding	IPI	24501689
GO:0042803	Molecular function	Protein homodimerization activity	TAS	8390097
GO:0045509	Molecular function	Interleukin-27 receptor activity	IC	14764690

Protein Information

Protein Name

Interleukin-6 receptor subunit beta, CD130 antigen, IL-6 receptor subunit beta, IL-6R subunit beta, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, gp130, oncostatin M receptor, interleukin receptor beta chain, membrane glycoprotein 130, membrane glycoprotein gp130, oncostatin-M receptor subunit alpha

Function

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).

UniProt

P40189

PDB

1N2Q, 1P9M, 1BJ8, 1BQU, 1I1R, 1PVH, 3L5H, 3L5I, 3L5J

Pfam

Pfam Accession	Pfam ID
PF00041	fn3
PF09240	IL6Ra-bind
PF06328	Lep_receptor_Ig

IL6ST

Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome.