INHA: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

INHA

Aliases

Entrez Gene ID

3623

Gene Name

Inhibin subunit alpha

Chromosomal Location

2q35

HGNC ID

HGNC:6065

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

e!Ensembl

Gene	ENSG00000123999
Transcript	ENST00000243786
Protein	ENSP00000243786

Gene Ontology (GO)

Show/Hide all(35 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001501	Biological process	Skeletal system development	TAS	10865214
GO:0001541	Biological process	Ovarian follicle development	NAS	9166111
GO:0007050	Biological process	Cell cycle arrest	TAS	12456957
GO:0007165	Biological process	Signal transduction	TAS	3267209
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	12456957
GO:0007267	Biological process	Cell-cell signaling	TAS	12456957
GO:0010862	Biological process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0030154	Biological process	Cell differentiation	TAS	12456957
GO:0030218	Biological process	Erythrocyte differentiation	NAS	1310063
GO:0042127	Biological process	Regulation of cell proliferation	IDA	9032295
GO:0042326	Biological process	Negative regulation of phosphorylation	TAS	12456957
GO:0042541	Biological process	Hemoglobin biosynthetic process	IDA	1310063
GO:0042981	Biological process	Regulation of apoptotic process	IBA	21873635
GO:0043408	Biological process	Regulation of MAPK cascade	IBA	21873635
GO:0045077	Biological process	Negative regulation of interferon-gamma biosynthetic process	TAS	12456957
GO:0045578	Biological process	Negative regulation of B cell differentiation	TAS	12456957
GO:0045650	Biological process	Negative regulation of macrophage differentiation	TAS	12456957
GO:0045786	Biological process	Negative regulation of cell cycle	TAS	12456957
GO:0046881	Biological process	Positive regulation of follicle-stimulating hormone secretion	TAS	12456957
GO:0046882	Biological process	Negative regulation of follicle-stimulating hormone secretion	NAS	3267209
GO:0048468	Biological process	Cell development	IBA	21873635
GO:0051726	Biological process	Regulation of cell cycle	IDA	9032295
GO:0060395	Biological process	SMAD protein signal transduction	IBA	21873635
GO:0005576	Cellular component	Extracellular region	TAS	12456957
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0034673	Cellular component	Inhibin-betaglycan-ActRII complex	IDA	10746731
GO:0043512	Cellular component	Inhibin A complex	IDA	7890768
GO:0005102	Molecular function	Signaling receptor binding	IPI	9032295
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	TAS	12456957
GO:0005160	Molecular function	Transforming growth factor beta receptor binding	IBA	21873635
GO:0005179	Molecular function	Hormone activity	TAS	12456957
GO:0005515	Molecular function	Protein binding	IPI	2575216, 12697670, 25416956, 25910212
GO:0005515	Molecular function	Protein binding	IPI	10746731
GO:0008083	Molecular function	Growth factor activity	TAS	12324653

Protein Information

Protein Name

Inhibin alpha chain, A-inhibin subunit, inhibin alpha subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

UniProt

P05111

Pfam

Pfam Accession	Pfam ID
PF00019	TGF_beta