INHBA: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

INHBA

Aliases

EDF, FRP

Entrez Gene ID

3624

Gene Name

Inhibin subunit beta A

Chromosomal Location

7p14.1

HGNC ID

HGNC:6066

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

e!Ensembl

Gene	ENSG00000122641
Transcript	ENST00000242208, ENST00000442711, ENST00000638023
Protein	ENSP00000242208, ENSP00000397197, ENSP00000490646

Gene Ontology (GO)

Show/Hide all(60 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000082	Biological process	G1/S transition of mitotic cell cycle	IDA	9884026
GO:0001541	Biological process	Ovarian follicle development	IGI	10932194
GO:0001541	Biological process	Ovarian follicle development	NAS	9166111
GO:0001942	Biological process	Hair follicle development	IGI	10932194
GO:0002244	Biological process	Hematopoietic progenitor cell differentiation	IDA	15451575
GO:0006357	Biological process	Regulation of transcription by RNA polymerase II	IDA	11948405
GO:0006952	Biological process	Defense response	TAS	12456957
GO:0007050	Biological process	Cell cycle arrest	IDA	9884026
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	12456957
GO:0007267	Biological process	Cell-cell signaling	TAS	12456957
GO:0007399	Biological process	Nervous system development	NAS	10320815
GO:0008285	Biological process	Negative regulation of cell proliferation	IDA	11948405
GO:0008584	Biological process	Male gonad development	IGI	10932194
GO:0009611	Biological process	Response to wounding	TAS	10320815
GO:0010628	Biological process	Positive regulation of gene expression	IDA	23812417
GO:0010862	Biological process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0010862	Biological process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IDA	19736306
GO:0021773	Biological process	Striatal medium spiny neuron differentiation	IDA	25804741
GO:0030154	Biological process	Cell differentiation	TAS	12456957
GO:0030218	Biological process	Erythrocyte differentiation	NAS	1310063
GO:0030308	Biological process	Negative regulation of cell growth	IDA	9884026, 20573232
GO:0032270	Biological process	Positive regulation of cellular protein metabolic process	IDA	21828274
GO:0032924	Biological process	Activin receptor signaling pathway	IDA	9884026
GO:0035987	Biological process	Endodermal cell differentiation	IDA	21828274
GO:0042326	Biological process	Negative regulation of phosphorylation	TAS	12456957
GO:0042476	Biological process	Odontogenesis	IGI	10932194
GO:0042493	Biological process	Response to drug	IDA	20573232
GO:0042541	Biological process	Hemoglobin biosynthetic process	IDA	1310063
GO:0042701	Biological process	Progesterone secretion	IGI	10932194
GO:0042981	Biological process	Regulation of apoptotic process	IBA	21873635
GO:0043408	Biological process	Regulation of MAPK cascade	IBA	21873635
GO:0045077	Biological process	Negative regulation of interferon-gamma biosynthetic process	TAS	12456957
GO:0045578	Biological process	Negative regulation of B cell differentiation	TAS	12456957
GO:0045648	Biological process	Positive regulation of erythrocyte differentiation	IDA	9032295
GO:0045650	Biological process	Negative regulation of macrophage differentiation	TAS	12456957
GO:0045786	Biological process	Negative regulation of cell cycle	IDA	9884026
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	21281489
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	12702211, 21281489
GO:0046880	Biological process	Regulation of follicle-stimulating hormone secretion	IGI	10932194
GO:0046881	Biological process	Positive regulation of follicle-stimulating hormone secretion	TAS	12456957
GO:0046882	Biological process	Negative regulation of follicle-stimulating hormone secretion	NAS	3267209
GO:0048468	Biological process	Cell development	IBA	21873635
GO:0060021	Biological process	Roof of mouth development	IGI	10932194
GO:0060395	Biological process	SMAD protein signal transduction	IBA	21873635
GO:0097154	Biological process	GABAergic neuron differentiation	IDA	25804741
GO:0097191	Biological process	Extrinsic apoptotic signaling pathway	IDA	9884026
GO:2001241	Biological process	Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	8267637
GO:0005576	Cellular component	Extracellular region	IDA	12213882
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0043509	Cellular component	Activin A complex	IDA	7890768
GO:0043512	Cellular component	Inhibin A complex	IDA	7890768
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IDA	9884026
GO:0005160	Molecular function	Transforming growth factor beta receptor binding	IBA	21873635
GO:0005179	Molecular function	Hormone activity	TAS	12456957
GO:0005515	Molecular function	Protein binding	IPI	2575216, 9032295, 12697670, 16482217
GO:0008083	Molecular function	Growth factor activity	TAS	12324653
GO:0017046	Molecular function	Peptide hormone binding	IPI	16198295
GO:0042802	Molecular function	Identical protein binding	IPI	2575216
GO:0070699	Molecular function	Type II activin receptor binding	IPI	7890768

Protein Information

Protein Name

Inhibin beta A chain, FSH-releasing protein, Inhibin, beta-1, activin beta-A chain, erythroid differentiation factor, erythroid differentiation protein, follicle-stimulating hormone-releasing protein, inhibin beta A subunit, inhibin, beta A (activin A, activin AB alpha polypeptide)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

UniProt

P08476

PDB

4MID, 3B4V, 2B0U, 2P6A, 1NYS, 1NYU, 1S4Y, 2ARP, 2ARV, 5HLY, 5HLZ

Pfam

Pfam Accession	Pfam ID
PF00019	TGF_beta
PF00688	TGFb_propeptide