INHBB: Polycystic Ovarian Syndrome Database

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INHBB

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

INHBB

Aliases

Entrez Gene ID

3625

Gene Name

Inhibin subunit beta B

Chromosomal Location

2q14.2

HGNC ID

HGNC:6067

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

e!Ensembl

Gene	ENSG00000163083
Transcript	ENST00000295228
Protein	ENSP00000295228

Gene Ontology (GO)

Show/Hide all(23 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001541	Biological process	Ovarian follicle development	NAS	12790766
GO:0006952	Biological process	Defense response	TAS	3122219
GO:0009611	Biological process	Response to wounding	IEP	10320815
GO:0010862	Biological process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0030154	Biological process	Cell differentiation	NAS	10320815
GO:0032924	Biological process	Activin receptor signaling pathway	IDA	16650820
GO:0042981	Biological process	Regulation of apoptotic process	IBA	21873635
GO:0043408	Biological process	Regulation of MAPK cascade	IBA	21873635
GO:0046881	Biological process	Positive regulation of follicle-stimulating hormone secretion	IPI	3122219
GO:0046882	Biological process	Negative regulation of follicle-stimulating hormone secretion	IPI	3122219
GO:0048178	Biological process	Negative regulation of hepatocyte growth factor biosynthetic process	IDA	12419948
GO:0048468	Biological process	Cell development	IBA	21873635
GO:0060395	Biological process	SMAD protein signal transduction	IBA	21873635
GO:0005576	Cellular component	Extracellular region	TAS	3122219
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0048471	Cellular component	Perinuclear region of cytoplasm	IDA	16650820
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	TAS	3122219
GO:0005160	Molecular function	Transforming growth factor beta receptor binding	IBA	21873635
GO:0005179	Molecular function	Hormone activity	TAS	3122219
GO:0005515	Molecular function	Protein binding	IPI	2575216, 12697670
GO:0042803	Molecular function	Protein homodimerization activity	IPI	2575216
GO:0046789	Molecular function	Host cell surface receptor binding	TAS	12456957

Protein Information

Protein Name

Inhibin beta B chain, Inhibin, beta-2, activin AB beta polypeptide, activin beta-B chain, inhibin beta B subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

UniProt

P09529

Pfam

Pfam Accession	Pfam ID
PF00019	TGF_beta
PF00688	TGFb_propeptide

Pathways
	KEGG	Reactome
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells	Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin

Interactions

STRING	MINT	IntAct
ENSP00000369927		P42330

View interactions

Associated Diseases

Show/Hide all(1 )

Disease group	Disease Name	References
Endocrine System Diseases
	Familial Testotoxicosis	16684832
	PCOS	16720653

References

Show/Hide all(16)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
11549651	Activin and follistatin	Follicle development		PCOS patients were otherwise healthy, between the ages of 1840 yr, had fewer than nine menses per yr, had been taking no medication for 3 months, and had biochemical and/or clinical evidence of hyperandrogenism. Each patient had at least two pelvic ultr	Related		These results suggest that insufficient production of inhibin alpha and possibly beta(A)-subunits, but not follistatin, is associated with follicular arrest in polycystic ovary syndrome follicles.
16030174	Inhibin A	Follicle development		Rotterdam criteria	Related		These data demonstrate that inhibin A and inhibin B concentrations are significantly reduced in the follicular fluid of women with PCOS compared with those in the follicular fluid of size-matched follicles from normal women, consistent with the decreased inhibin subunit mRNA expression in previous studies.
16359965	E(2)			Adams et al.	Related	Italy and New York-46 PCOS and 25 controls	Measurements of MIS reflect ovarian findings in PCOS better than levels of inhibin B and are more frequently elevated. However, MIS lacks sensitivity for use as a diagnostic tool in PCOS.
16720653	E(2)	Follicle development			Related		In PCOS women, the 24-h production of inhibin B and E(2) after FSH was significantly greater than that of normal controls.
18285408	DHEA			Either oligomenorrheic or amenorrheic, and all exhibited clinical and biochemical evidence of hyperandrogenism.Each PCOS subject exhibited ultrasound evidence of bilaterally enlarged polycystic ovaries and greater than 12 follicles per ovary.	Related		After FSH injection, PCOS women demonstrated enhanced production of 17-OHP, A, DHEA, and Inh B, whereas in normal women no increases were observed. T levels declined slightly in both groups.
13680268	E(2)	Ovulatory cycles			Related		It has been observed that as day 3 serum inhibin B levels increased in women with PCOS, the ovulatory response to gonadotropins and the rate of ovulatory cycles increased significantly.
12466353	SHBG				Related		These findings suggest that both increased LH and insulin may account for the relative suppression of inhibin B in patients with PCOS.
11720900	DHEA				Related		Advanced age in normogonadotrophic anovulatory infertile women is associated with lower LH and androgen levels and with a decreased number of ovarian follicles. Although during reproductive years observed differences are relatively small, these age-related changes may affect the observed incidence of PCO
11574495	E(2)				Related		Basal inhibin concentrations may determine poor and good responders to ovulation induction with very low dose gonadotrophin protocol in patients with PCOS. The day 12 inhibin concentration was found to be a more sensitive parameter than the oestradiol concentration in the prediction of follicular maturation.
10785223	Inhibin A,alpha-inhibin, pro-alphaC (alpha-inhibin precursor proteins),E(2)			The diagnosis of PCOS was based on the association of one clinical criterion (hirsutism as assessed by a modified Ferriman-Gallwey score >8, menstrual and/or ovulatory disturbances, or minor signs such as acne or seborrhea) with one biologic criterion (se	Related		Among women with PCOS, the trend toward an excess serum inhibin B level is observed exclusively in nonobese patients.
9666869	Inhibin A,E(2)	Follicle arrest,follicle development			Related		The raised concentrations of inhibin A and B in women with PCOS probably reflects the increased number of small antral follicles characteristically present in that condition
8528356		Hypogonadotropic amenorrhea		A diagnosis of PCOD was made when there was 1) amenorrhea or chronic anovulation with peripubertal onset of menstrual irregularlities, 2) a high serum LH level in the presence of a normal or low FSH level, 3) multiple cysts on ovaries revealed by pelvic u	Related		These results indicated that basal IR-inhibin levels vary with types of amenorrhea. High IR-inhibin levels in PCOD patients suggest that inhibin plays a part in the discordant gonadotropin secretion in these patients.
8370711	Inhibin alpha, beta A				Related		The present findings suggest that immunoreactive inhibin alpha-, beta A-, and beta B-subunits are present in hyperplastic thecal and stromal cells in PCO, and that granulosa cells in the follicular cyst of PCO might not produce inhibin, in contrast to the normal ovary.
2128878					Related		PCOS ovaries totally may secrete more inhibin than normal ovaries. This higher potency of PCOS ovaries to secrete inhibin along with higher serum estrogen levels may be responsible for the disparity between basal LH and FSH levels in PCOS
19240152		Ovarian dysfunction		NIH criteria	Related		Typical PCOS is characterized by intrinsic ovarian hypersensitivity to hCG to which excessive paracrine FSH signaling via inhibin-B may contribute. Atypical PCOS is due to a unique type of ovarian dysfunction that is relatively gonadotropin hyposensitive.
20630504	TGF- 1,TGF- 2	Hyperandrogenism, insulin resistance		NIH criteria	Related		Allele8- PCOS is associated with higher levels of TGF-1 compared with A8+ PCOS or A8- Non-PCOS, similar levels of TGF-2 compared with A8+ PCOS but lower levels of TGF-2 compared with A8- Non-PCOS, and lower levels of inhibin B and aldosterone compared with A8+ PCOS.

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