ITGAM: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ITGAM

Aliases

CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6

Entrez Gene ID

3684

Gene Name

Integrin subunit alpha M

Chromosomal Location

16p11.2

HGNC ID

HGNC:6149

Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RefSeq DNA

NG_011719.1

RefSeq mRNA

NM_001145808.2, NM_000632.4

e!Ensembl

Gene	ENSG00000169896
Transcript	ENST00000648685, ENST00000544665, ENST00000567031, ENST00000565142
Protein	ENSP00000496959, ENSP00000441691, ENSP00000454568, ENSP00000461850

Gene Ontology (GO)

Show/Hide all(16 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007155	Biological process	Cell adhesion	TAS	2563162
GO:0010668	Biological process	Ectodermal cell differentiation	IEP	23154389
GO:0032930	Biological process	Positive regulation of superoxide anion generation	IGI	21193407
GO:0043315	Biological process	Positive regulation of neutrophil degranulation	IGI	21193407
GO:0098742	Biological process	Cell-cell adhesion via plasma-membrane adhesion molecules	NAS	20199584
GO:0005615	Cellular component	Extracellular space	IDA	25645918
GO:0005886	Cellular component	Plasma membrane	IDA	28807980
GO:0008305	Cellular component	Integrin complex	TAS	2563162
GO:0009897	Cellular component	External side of plasma membrane	NAS	20199584
GO:0009986	Cellular component	Cell surface	HDA	23981064
GO:0009986	Cellular component	Cell surface	IDA	19234460
GO:0044853	Cellular component	Plasma membrane raft	IDA	21193407
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0005515	Molecular function	Protein binding	IPI	15004192, 15194813, 16246332, 21193407
GO:0031072	Molecular function	Heat shock protein binding	IPI	12496435
GO:0046982	Molecular function	Protein heterodimerization activity	NAS	20199584

Protein Information

Protein Name

Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, antigen CD11b (p170), cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, integrin, alpha M (complement component 3 receptor 3 subunit), leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, neutrophil adherence receptor alpha-M subunit

Function

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).

Refseq Proteins

NP_001139280.1, NP_000623.2

UniProt

P11215

PDB

4M76, 1A8X, 1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4XW2

Pfam

Pfam Accession	Pfam ID
PF01839	FG-GAP
PF00357	Integrin_alpha
PF08441	Integrin_alpha2
PF00092	VWA