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Gene Information   Gene Symbol ITLN1   Aliases HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin   Entrez Gene ID 55600   Gene Name Intelectin 1   Chromosomal Location 1q23.3   HGNC ID HGNC:18259   e!Ensembl Gene ENSG00000179914 Transcript ENST00000326245   Protein ENSP00000323587 Gene Ontology (GO) Show/Hide all(8 ) GO ID Ontology Function Evidence Reference GO:0001934 Biological process Positive regulation of protein phosphorylation IDA 16531507 GO:0046326 Biological process Positive regulation of glucose import IDA 16531507 GO:0070207 Biological process Protein homotrimerization IDA 26148048 GO:0043235 Cellular component Receptor complex IDA 23382219 GO:0070062 Cellular component Extracellular exosome HDA 19056867 GO:0005509 Molecular function Calcium ion binding IDA 26148048 GO:0042802 Molecular function Identical protein binding IPI 26148048 GO:0070492 Molecular function Oligosaccharide binding IDA 26148048 Protein Information   Protein Name Intelectin-1, ITLN-1, endothelial lectin HL-1, galactofuranose-binding lectin, intelectin 1 (galactofuranose binding), intestinal lactoferrin receptor   Function Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).   UniProt Q8WWA0   PDB 4WMQ, 4WMY

Pathways   Reactome     Antimicrobial peptides

Interactions   STRING MINT IntAct ENSP00000222553 P43490 P43490     View interactions       Associated Diseases Show/Hide all(4 ) Disease group Disease Name References Digestive System Diseases Crohn Disease 18587394 Inflammatory Bowel Diseases 26192919 Endocrine System Diseases Diabetes Mellitus 23555749 PCOS 30566253, 21865408 Neoplasms Mesothelioma 15777968 Multiple Sclerosis 22190364 Respiratory Tract Diseases Asthma 21150878 References     Show/Hide all(3) PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion 24524360  RARRES2(chemerin)  PCOS, insulin resistance (IR), Type 2 Diabetes    Rotterdam criteria  Related  81 lean and obese women with PCOS, 61 lean and obese controls   Fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS  24392647          Direct  87 PCOS (obese), 72 non-PCOS women (41 obese)  Omentin-1 level was significantly lower in the PCOS compared with the non-PCOS group, and not related to body mass  18174521          Related    Decreased plasma omentin-1 levels was observed in women with PCOS, compared with control subjects, there was significantly lower levels of omentin-1 mRNA and protein in omental adipose tissue of women with PCOS

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