JUN: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

JUN

Aliases

AP-1, AP1, c-Jun, cJUN, p39

Entrez Gene ID

3725

Gene Name

Jun proto-oncogene, AP-1 transcription factor subunit

Chromosomal Location

1p32.1

HGNC ID

HGNC:6204

Summary

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_047027.1

RefSeq mRNA

NM_002228.3, NM_002228.4

e!Ensembl

Gene	ENSG00000177606
Transcript	ENST00000371222
Protein	ENSP00000360266

Gene Ontology (GO)

Show/Hide all(66 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007179	Biological process	Transforming growth factor beta receptor signaling pathway	IDA	9732876
GO:0007265	Biological process	Ras protein signal transduction	IDA	24623306
GO:0009314	Biological process	Response to radiation	IBA	21873635
GO:0009612	Biological process	Response to mechanical stimulus	IBA	21873635
GO:0010033	Biological process	Response to organic substance	IBA	21873635
GO:0032496	Biological process	Response to lipopolysaccharide	IBA	21873635
GO:0032870	Biological process	Cellular response to hormone stimulus	IBA	21873635
GO:0034097	Biological process	Response to cytokine	IBA	21873635
GO:0034614	Biological process	Cellular response to reactive oxygen species	IMP	26514923
GO:0042493	Biological process	Response to drug	IBA	21873635
GO:0043065	Biological process	Positive regulation of apoptotic process	IMP	10508860
GO:0043392	Biological process	Negative regulation of DNA binding	IDA	14645924
GO:0043922	Biological process	Negative regulation by host of viral transcription	IDA	2833704
GO:0043923	Biological process	Positive regulation by host of viral transcription	IDA	2833704
GO:0045597	Biological process	Positive regulation of cell differentiation	IBA	21873635
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	2833704
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	2833704, 9732876, 22083952
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	26514923
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	2833704, 10508860, 12490281, 19861239
GO:0051591	Biological process	Response to cAMP	IBA	21873635
GO:0051726	Biological process	Regulation of cell cycle	IBA	21873635
GO:0060395	Biological process	SMAD protein signal transduction	IDA	9732876
GO:0071276	Biological process	Cellular response to cadmium ion	IMP	26514923
GO:1902895	Biological process	Positive regulation of pri-miRNA transcription by RNA polymerase II	IMP	19962668, 24375836
GO:1904707	Biological process	Positive regulation of vascular smooth muscle cell proliferation	IMP	28701355
GO:1990441	Biological process	Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	21113145
GO:2000144	Biological process	Positive regulation of DNA-templated transcription, initiation	IDA	23027619
GO:0000228	Cellular component	Nuclear chromosome	TAS	10918580
GO:0000790	Cellular component	Nuclear chromatin	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	21113145
GO:0005654	Cellular component	Nucleoplasm	IBA	21873635
GO:0005667	Cellular component	Transcription factor complex	IBA	21873635
GO:0005719	Cellular component	Nuclear euchromatin	IDA	19861239
GO:0035976	Cellular component	Transcription factor AP-1 complex	IDA	10508860
GO:0035976	Cellular component	Transcription factor AP-1 complex	IMP	26514923
GO:0000976	Molecular function	Transcription regulatory region sequence-specific DNA binding	IDA	22083952
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IBA	21873635
GO:0000980	Molecular function	RNA polymerase II distal enhancer sequence-specific DNA binding	IDA	19861239
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	IC	21113145
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	2833704, 19861239
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0001102	Molecular function	RNA polymerase II activating transcription factor binding	IPI	10508860, 19861239
GO:0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	19861239
GO:0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	19962668
GO:0003677	Molecular function	DNA binding	TAS	2825349
GO:0003700	Molecular function	DNA-binding transcription factor activity	IDA	9732876
GO:0003713	Molecular function	Transcription coactivator activity	IBA	21873635
GO:0003713	Molecular function	Transcription coactivator activity	IDA	2833704
GO:0003723	Molecular function	RNA binding	HDA	22681889
GO:0005096	Molecular function	GTPase activator activity	IDA	11804590
GO:0005515	Molecular function	Protein binding	IPI	7816143, 8440710, 10327051, 10393177, 10428834, 11738026, 12676957, 15334056, 15378002, 15626733, 15894542, 16291755, 16533805, 18003900, 18165900, 18172215, 19028685, 19064921, 19074269, 19527717, 20102225, 20195357, 20511396, 20557936, 20852630, 20936779, 21199371, 21555589, 21988
GO:0008134	Molecular function	Transcription factor binding	IBA	21873635
GO:0008134	Molecular function	Transcription factor binding	IPI	16007074
GO:0019899	Molecular function	Enzyme binding	IPI	23382074
GO:0031625	Molecular function	Ubiquitin protein ligase binding	IPI	14739464
GO:0035497	Molecular function	CAMP response element binding	IDA	19861239
GO:0042802	Molecular function	Identical protein binding	IPI	20102225, 25609649
GO:0042803	Molecular function	Protein homodimerization activity	IDA	10508860
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IDA	9732876, 14645924, 21113145, 24623306
GO:0044389	Molecular function	Ubiquitin-like protein ligase binding	IPI	27458189
GO:0046982	Molecular function	Protein heterodimerization activity	IDA	10508860
GO:0070412	Molecular function	R-SMAD binding	IPI	9732876

Protein Information

Protein Name

Transcription factor AP-1, Jun activation domain binding protein, activator protein 1, enhancer-binding protein AP1, jun oncogene, proto-oncogene c-Jun, proto-oncogene cJun, v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma virus 17 oncogene homolog

Function

Refseq Proteins

NP_002219.1

UniProt

P05412

PDB

1T2K, 1A02, 1FOS, 1S9K, 1JNM, 1JUN, 5FV8, 5T01

Pfam

Pfam Accession	Pfam ID
PF00170	bZIP_1
PF03957	Jun