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Gene Symbol |
JUNB |
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Aliases |
AP-1 |
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Entrez Gene ID |
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Gene Name |
JunB proto-oncogene, AP-1 transcription factor subunit |
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Chromosomal Location |
19p13.13 |
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HGNC ID |
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0000122 |
Biological process |
Negative regulation of transcription by RNA polymerase II |
IBA |
21873635 |
| GO:0006357 |
Biological process |
Regulation of transcription by RNA polymerase II |
TAS |
2513129 |
| GO:0009314 |
Biological process |
Response to radiation |
IBA |
21873635 |
| GO:0009612 |
Biological process |
Response to mechanical stimulus |
IBA |
21873635 |
| GO:0010033 |
Biological process |
Response to organic substance |
IBA |
21873635 |
| GO:0032496 |
Biological process |
Response to lipopolysaccharide |
IBA |
21873635 |
| GO:0032870 |
Biological process |
Cellular response to hormone stimulus |
IBA |
21873635 |
| GO:0034097 |
Biological process |
Response to cytokine |
IBA |
21873635 |
| GO:0042493 |
Biological process |
Response to drug |
IBA |
21873635 |
| GO:0045597 |
Biological process |
Positive regulation of cell differentiation |
IBA |
21873635 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IBA |
21873635 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IDA |
10508860 |
| GO:0051591 |
Biological process |
Response to cAMP |
IBA |
21873635 |
| GO:0051726 |
Biological process |
Regulation of cell cycle |
IBA |
21873635 |
| GO:0000785 |
Cellular component |
Chromatin |
TAS |
2513129 |
| GO:0000790 |
Cellular component |
Nuclear chromatin |
IBA |
21873635 |
| GO:0005654 |
Cellular component |
Nucleoplasm |
IBA |
21873635 |
| GO:0005667 |
Cellular component |
Transcription factor complex |
IBA |
21873635 |
| GO:0035976 |
Cellular component |
Transcription factor AP-1 complex |
IDA |
10508860 |
| GO:0000978 |
Molecular function |
RNA polymerase II proximal promoter sequence-specific DNA binding |
IBA |
21873635 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISM |
19274049 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
NAS |
19274049 |
| GO:0003677 |
Molecular function |
DNA binding |
TAS |
10764760 |
| GO:0003713 |
Molecular function |
Transcription coactivator activity |
IBA |
21873635 |
| GO:0003714 |
Molecular function |
Transcription corepressor activity |
TAS |
2513129 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
16189514, 16511568, 18692475, 19064921, 19321746, 20102225, 20195357, 21988832, 24029232, 25416956, 25609649, 26496610, 29997244, 30833792 |
| GO:0008134 |
Molecular function |
Transcription factor binding |
IBA |
21873635 |
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| Protein Information |
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Protein Name |
Transcription factor jun-B, activator protein 1, jun B proto-oncogene |
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Function |
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UniProt |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000294304 |
O75197 |
O75197 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Myocardial Ischemia |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Lung Cancer |
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| Nervous System Diseases |
| Status Epilepticus |
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| Brain Infarction |
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| Petit mal status |
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| Cerebral Artery Infarction |
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| Middle Cerebral Artery Syndrome |
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| Cerebral Thrombosis |
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| Psychiatric/Brain disorders |
| Obstructive Sleep Apnea |
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References |
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| Aydos Alp, Gurel Aykut, Oztemur Islakoglu Yasemin, Noyan Senem, Gokce Bagdagul, Ecemis Tolga, Kaya Cemil, Aksu Arif Tarik, Gur Dedeoglu Bala |
| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, Medicana International Ankara Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, Liv Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, TOBB ETU Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey. |
| PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875. |
Abstract
Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with prevalence of 8-18%. The oocyte within the follicle is surrounded by cumulus cells (CCs), which connect with mural granulosa cells (MGCs) that are responsible for secreting steroid hormones. The main aim of this study is comparing gene expression profiles of MGCs and CCs in PCOS and control samples to identify PCOS-specific differentially expressed genes (DEGs). In this study, two microarray databases were searched for mRNA expression microarray studies performed with CCs and MGCs obtained from PCOS patients and control samples. Three independent studies were selected to be integrated with naive meta-analysis since raw meta-data from these studies were found to be highly correlated. DEGs in these somatic cells were identified for PCOS and control groups. This study enabled us to reveal dysregulation in MAPK (mitogen activated protein kinase), insulin and Wnt signaling pathways between CCs and MGCs in PCOS. The meta-analysis results together with qRT-PCR validations provide evidence that molecular signaling is dysregulated through MGCs and CCs in PCOS, which is important for follicle and oocyte maturation and may contribute to the pathogenesis of the syndrome. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
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