KLK3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

KLK3

Aliases

APS, KLK2A1, PSA, hK3

Entrez Gene ID

354

Gene Name

Kallikrein related peptidase 3

Chromosomal Location

19q13.33

HGNC ID

HGNC:6364

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]

RefSeq DNA

NG_011653.1

RefSeq mRNA

NM_001648.2, NM_001030047.1, NM_001030048.1

e!Ensembl

Gene	ENSG00000142515
Transcript	ENST00000601503, ENST00000596185, ENST00000326003, ENST00000422986, ENST00000597286, ENST00000597483, ENST00000593997, ENST00000595392, ENST00000595952, ENST00000360617, ENST00000598145, ENST00000617027
Protein	ENSP00000472213, ENSP00000471648, ENSP00000314151, ENSP00000393628, ENSP00000470523, ENSP00000472411, ENSP00000472907, ENSP00000468912, ENSP00000471155, ENSP00000353829, ENSP00000471827, ENSP00000483513

Gene Ontology (GO)

Show/Hide all(16 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002778	Biological process	Antibacterial peptide production	IDA	18714013
GO:0003073	Biological process	Regulation of systemic arterial blood pressure	IBA	21873635
GO:0006508	Biological process	Proteolysis	IMP	15563730
GO:0016525	Biological process	Negative regulation of angiogenesis	NAS	10675891
GO:0031638	Biological process	Zymogen activation	IBA	21873635
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005615	Cellular component	Extracellular space	IDA	8665956
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0030141	Cellular component	Secretory granule	IBA	21873635
GO:0032991	Cellular component	Protein-containing complex	IDA	8665956
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0004175	Molecular function	Endopeptidase activity	IDA	18714013
GO:0004252	Molecular function	Serine-type endopeptidase activity	IMP	15563730
GO:0005515	Molecular function	Protein binding	IPI	1725227, 8665956, 19345326, 25241761
GO:0008236	Molecular function	Serine-type peptidase activity	TAS	2470553
GO:0016811	Molecular function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IMP	8665956

Protein Information

Protein Name

Prostate-specific antigen, P-30 antigen, gamma-seminoprotein, kallikrein-3, semenogelase, seminin

Function

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Refseq Proteins

NP_001639.1, NP_001025218.1, NP_001025219.1

UniProt

P07288

PDB

1PFA, 2PSA, 2ZCH, 2ZCK, 2ZCL, 3QUM

Pfam

Pfam Accession	Pfam ID
PF00089	Trypsin